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CNPPD1 cyclin Pas1/PHO80 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 27013, updated on 1-Mar-2024

Summary

Official Symbol
CNPPD1provided by HGNC
Official Full Name
cyclin Pas1/PHO80 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25220
See related
Ensembl:ENSG00000115649 AllianceGenome:HGNC:25220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-57; C2orf24
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be integral component of membrane. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 36.9), adrenal (RPKM 24.4) and 25 other tissues See more
Orthologs
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Genomic context

See CNPPD1 in Genome Data Viewer
Location:
2q35
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219171897..219178156, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219660322..219666583, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220036619..220042878, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene non-homologous end joining factor 1 Neighboring gene RNA, 7SL, cytoplasmic 764, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12340 Neighboring gene solute carrier family 23 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17140 Neighboring gene Sharpr-MPRA regulatory region 9830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12343 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220042692-220043192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12346 Neighboring gene reticulophagy regulator family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220072463-220072962 Neighboring gene zinc finger AN1-type containing 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein CNPPD1
Names
cyclin Pas1/PHO80 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321389.2NP_001308318.2  protein CNPPD1

    Status: VALIDATED

    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS2433.1
    UniProtKB/Swiss-Prot
    B2RC77, O75548, Q9BV87, Q9H4N0, Q9UQN0
    UniProtKB/TrEMBL
    B3KQN8
    Related
    ENSP00000386277.1, ENST00000409789.5
  2. NM_001321390.2NP_001308319.2  protein CNPPD1

    Status: VALIDATED

    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS2433.1
    UniProtKB/Swiss-Prot
    B2RC77, O75548, Q9BV87, Q9H4N0, Q9UQN0
    UniProtKB/TrEMBL
    B3KQN8
    Conserved Domains (1) summary
    cl00050
    Location:85174
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  3. NM_001321391.2NP_001308320.2  protein CNPPD1

    Status: VALIDATED

    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS2433.1
    UniProtKB/Swiss-Prot
    B2RC77, O75548, Q9BV87, Q9H4N0, Q9UQN0
    UniProtKB/TrEMBL
    B3KQN8
    Conserved Domains (1) summary
    cl00050
    Location:85174
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  4. NM_015680.6NP_056495.4  protein CNPPD1

    Status: VALIDATED

    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS2433.1
    UniProtKB/Swiss-Prot
    B2RC77, O75548, Q9BV87, Q9H4N0, Q9UQN0
    UniProtKB/TrEMBL
    B3KQN8
    Related
    ENSP00000353698.5, ENST00000360507.10
    Conserved Domains (1) summary
    cl00050
    Location:85174
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RNA

  1. NR_135628.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068946
  2. NR_135629.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068946

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    219171897..219178156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219660322..219666583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)