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FETUB fetuin B [ Homo sapiens (human) ]

Gene ID: 26998, updated on 20-Sep-2020

Summary

Official Symbol
FETUBprovided by HGNC
Official Full Name
fetuin Bprovided by HGNC
Primary source
HGNC:HGNC:3658
See related
Ensembl:ENSG00000090512 MIM:605954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
16G2; Gugu; IRL685
Summary
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 42.7) See more
Orthologs

Genomic context

See FETUB in Genome Data Viewer
Location:
3q27.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (186635969..186653141)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186353758..186370797)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9080 Neighboring gene uncharacterized LOC100287402 Neighboring gene alpha 2-HS glycoprotein Neighboring gene uncharacterized LOC105374258 Neighboring gene histidine rich glycoprotein Neighboring gene histidine rich glycoprotein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 binds to the natural glycoprotein fetuin PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
binding of sperm to zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
 
biological_process ND
No biological Data available
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
single fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fetuin-B
Names
fetuin-like protein IRL685

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308077.4NP_001295006.1  fetuin-B isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Consensus CDS
    CCDS82884.1
    UniProtKB/Swiss-Prot
    Q9UGM5
    Related
    ENSP00000371571.3, ENST00000382136.3
    Conserved Domains (1) summary
    smart00043
    Location:113218
    CY; Cystatin-like domain
  2. NM_001308079.4NP_001295008.1  fetuin-B isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Consensus CDS
    CCDS77871.1
    UniProtKB/Swiss-Prot
    Q9UGM5
    UniProtKB/TrEMBL
    E9PG08, Q5J875
    Related
    ENSP00000371569.3, ENST00000382134.7
    Conserved Domains (1) summary
    smart00043
    Location:85190
    CY; Cystatin-like domain
  3. NM_001375587.2NP_001362516.1  fetuin-B isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Related
    ENSP00000404288.1, ENST00000450521.5
  4. NM_001375588.2NP_001362517.1  fetuin-B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC068631
  5. NM_001375589.2NP_001362518.1  fetuin-B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Conserved Domains (1) summary
    smart00043
    Location:2107
    CY; Cystatin-like domain
  6. NM_001375590.2NP_001362519.1  fetuin-B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Conserved Domains (1) summary
    smart00043
    Location:2107
    CY; Cystatin-like domain
  7. NM_001375591.2NP_001362520.1  fetuin-B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Conserved Domains (1) summary
    smart00043
    Location:2107
    CY; Cystatin-like domain
  8. NM_001375592.2NP_001362521.1  fetuin-B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Conserved Domains (1) summary
    smart00043
    Location:2107
    CY; Cystatin-like domain
  9. NM_014375.3NP_055190.2  fetuin-B isoform 1 precursor

    See identical proteins and their annotated locations for NP_055190.2

    Status: REVIEWED

    Source sequence(s)
    AC068631, AJ242928, BC069670, BX115543
    Consensus CDS
    CCDS3279.1
    UniProtKB/Swiss-Prot
    Q9UGM5
    Related
    ENSP00000265029.3, ENST00000265029.8
    Conserved Domains (1) summary
    smart00043
    Location:150255
    CY; Cystatin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    186635969..186653141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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