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Map3k10 mitogen-activated protein kinase kinase kinase 10 [ Mus musculus (house mouse) ]

Gene ID: 269881, updated on 17-Aug-2024

Summary

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Official Symbol
Map3k10provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 10provided by MGI
Primary source
MGI:MGI:1346879
See related
Ensembl:ENSMUSG00000040390 AllianceGenome:MGI:1346879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MST; Mlk2
Summary
Enables protein kinase activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription, DNA-templated and protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in brown fat; heart; ovary; renal vasculature; and testis. Orthologous to human MAP3K10 (mitogen-activated protein kinase kinase kinase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 23.3), frontal lobe adult (RPKM 19.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 15.95 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27355800..27374059, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27656375..27674630, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28376489-28376676 Neighboring gene STARR-positive B cell enhancer ABC_E11346 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28377425-28377608 Neighboring gene thymoma viral proto-oncogene 2 Neighboring gene STARR-seq mESC enhancer starr_18379 Neighboring gene predicted gene, 38973 Neighboring gene tetratricopeptide repeat domain 9B Neighboring gene STARR-seq mESC enhancer starr_18383 Neighboring gene zinc finger protein 607B Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28474189-28474376 Neighboring gene STARR-seq mESC enhancer starr_18384 Neighboring gene PHD finger protein 5B, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of mixed lineage kinase 2 in germ cells of the testis. Phelan DR, et al. Mol Reprod Dev, 1999 Feb. PMID 9890743
  2. Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity. Kant S, et al. Cell Rep, 2013 Aug 29. PMID 23954791, Free PMC Article
  3. Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype. Bisson N, et al. Cell Cycle, 2008 Apr 1. PMID 18414056
  4. The corepressor activity of Alien is controlled by CREB-binding protein/p300. Eckey M, et al. FEBS J, 2013 Apr. PMID 23441852
  5. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. Pedraza N, et al. J Biol Chem, 2009 Nov 20. PMID 19801649, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways
    Title: Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways.
  2. There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse.
    Title: Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 10
Names
MKN28 derived nonreceptor_type
MKN28 kinase
mixed lineage kinase 2
serine/threonine kinase
NP_001277457.1
XP_017177776.1
XP_017177777.1
XP_017177778.1
XP_017177779.1
XP_030098477.1
XP_030098478.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290528.1 → NP_001277457.1  mitogen-activated protein kinase kinase kinase 10

    See identical proteins and their annotated locations for NP_001277457.1

    Status: VALIDATED

    Source sequence(s)
    AK053830, BC078445
    Consensus CDS
    CCDS39850.2
    UniProtKB/Swiss-Prot
    Q66L42, Q80UW4
    UniProtKB/TrEMBL
    D3YXM8
    Related
    ENSMUSP00000037725.8, ENSMUST00000036453.14
    Conserved Domains (3) summary
    smart00219
    Location:98 → 357
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:20 → 76
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cl21453
    Location:103 → 360
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27355800..27374059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322288.3 → XP_017177777.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

    UniProtKB/TrEMBL
    D3YXM8
    Conserved Domains (2) summary
    cd12059
    Location:20 → 76
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cl21453
    Location:103 → 360
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017322289.3 → XP_017177778.1  mitogen-activated protein kinase kinase kinase 10 isoform X3

    UniProtKB/TrEMBL
    D3YXM8
    Conserved Domains (2) summary
    cd12059
    Location:20 → 76
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cl21453
    Location:103 → 368
    PKc_like; Protein Kinases, catalytic domain

  3. XM_017322287.3 → XP_017177776.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

    UniProtKB/TrEMBL
    D3YXM8
    Conserved Domains (2) summary
    cd12059
    Location:20 → 76
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cl21453
    Location:103 → 368
    PKc_like; Protein Kinases, catalytic domain

  4. XM_030242618.2 → XP_030098478.1  mitogen-activated protein kinase kinase kinase 10 isoform X6

    Conserved Domains (2) summary
    TIGR03319
    Location:4 → 88
    RNase_Y; ribonuclease Y
    PHA03247
    Location:252 → 550
    PHA03247; large tegument protein UL36; Provisional

  5. XM_030242617.2 → XP_030098477.1  mitogen-activated protein kinase kinase kinase 10 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:295 → 593
    PHA03247; large tegument protein UL36; Provisional
    pfam12072
    Location:72 → 132
    DUF3552; Domain of unknown function (DUF3552)

  6. XM_017322290.3 → XP_017177779.1  mitogen-activated protein kinase kinase kinase 10 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:410 → 708
    PHA03247; large tegument protein UL36; Provisional
    pfam12072
    Location:187 → 247
    DUF3552; Domain of unknown function (DUF3552)
    cl21453
    Location:1 → 108
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004934110.1 RNA Sequence

  2. XR_004934109.1 RNA Sequence

  3. XR_001785564.3 RNA Sequence

  4. XR_004934112.1 RNA Sequence

  5. XR_004934111.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081292.1: Suppressed sequence

    Description
    NM_001081292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66L42.2 GenPept UniProtKB/Swiss-Prot:Q66L42

Gene LinkOut

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