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Map3k10 mitogen-activated protein kinase kinase kinase 10 [ Mus musculus (house mouse) ]

Gene ID: 269881, updated on 5-Aug-2018

Summary

Official Symbol
Map3k10provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 10provided by MGI
Primary source
MGI:MGI:1346879
See related
Ensembl:ENSMUSG00000040390 Vega:OTTMUSG00000023963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MST; Mlk2; BC028668; BC046514
Expression
Ubiquitous expression in cortex adult (RPKM 23.3), frontal lobe adult (RPKM 19.8) and 25 other tissues See more
Orthologs

Genomic context

See Map3k10 in Genome Data Viewer
Location:
7; 7 A3
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (27656375..27674611, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (28441396..28459617, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38973 Neighboring gene tetratricopeptide repeat domain 9B Neighboring gene zinc finger protein 607B Neighboring gene predicted gene, 45976 Neighboring gene PHD finger protein 5B, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IPI
Inferred from Physical Interaction
more info
PubMed 
smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 10
Names
MKN28 derived nonreceptor_type
MKN28 kinase
mixed lineage kinase 2
serine/threonine kinase
NP_001277457.1
XP_017177776.1
XP_017177777.1
XP_017177778.1
XP_017177779.1
XP_017177780.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290528.1NP_001277457.1  mitogen-activated protein kinase kinase kinase 10

    See identical proteins and their annotated locations for NP_001277457.1

    Status: VALIDATED

    Source sequence(s)
    AK053830, BC078445
    Consensus CDS
    CCDS39850.2
    UniProtKB/Swiss-Prot
    Q66L42
    Related
    ENSMUSP00000037725.7, OTTMUSP00000028391, ENSMUST00000036453.13, OTTMUST00000058564
    Conserved Domains (3) summary
    smart00219
    Location:98357
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:2076
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cl21453
    Location:103360
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    27656375..27674611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322287.1XP_017177776.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

  2. XM_017322288.1XP_017177777.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

  3. XM_017322289.1XP_017177778.1  mitogen-activated protein kinase kinase kinase 10 isoform X3

  4. XM_017322291.1XP_017177780.1  mitogen-activated protein kinase kinase kinase 10 isoform X5

  5. XM_017322290.1XP_017177779.1  mitogen-activated protein kinase kinase kinase 10 isoform X4

RNA

  1. XR_001785564.1 RNA Sequence

  2. XR_001785565.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081292.1: Suppressed sequence

    Description
    NM_001081292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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