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MAP3K10 mitogen-activated protein kinase kinase kinase 10 [ Homo sapiens (human) ]

Gene ID: 4294, updated on 12-May-2019

Summary

Official Symbol
MAP3K10provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 10provided by HGNC
Primary source
HGNC:HGNC:6849
See related
Ensembl:ENSG00000130758 MIM:600137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST; MLK2; MEKK10
Summary
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 11.1), testis (RPKM 4.1) and 24 other tissues See more
Orthologs

Genomic context

See MAP3K10 in Genome Data Viewer
Location:
19q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (40191657..40215575)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40697504..40721487)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 780A Neighboring gene vomeronasal 1 receptor 96 pseudogene Neighboring gene tetratricopeptide repeat domain 9B Neighboring gene cyclin N-terminal domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JUN kinase kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
JNK cascade TAS
Traceable Author Statement
more info
PubMed 
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of JNKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 10
Names
MKN28 derived nonreceptor_type serine/threonine kinase
MKN28 kinase
mixed lineage kinase 2
protein kinase MST
NP_002437.2
XP_006723286.1
XP_011525283.1
XP_011525284.1
XP_024307287.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002446.4NP_002437.2  mitogen-activated protein kinase kinase kinase 10

    See identical proteins and their annotated locations for NP_002437.2

    Status: REVIEWED

    Source sequence(s)
    AC011496, BF594729, BU633407, X90846, Z48615
    Consensus CDS
    CCDS12549.1
    UniProtKB/Swiss-Prot
    Q02779
    Related
    ENSP00000253055.2, ENST00000253055.8
    Conserved Domains (3) summary
    smart00219
    Location:98357
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:2076
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14148
    Location:103360
    STKc_MLK2; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    40191657..40215575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526981.2XP_011525283.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

    Conserved Domains (3) summary
    smart00219
    Location:98365
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:2076
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cl21453
    Location:103368
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011526982.3XP_011525284.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

    Conserved Domains (3) summary
    smart00219
    Location:98365
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:2076
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cl21453
    Location:103368
    PKc_like; Protein Kinases, catalytic domain
  3. XM_024451519.1XP_024307287.1  mitogen-activated protein kinase kinase kinase 10 isoform X3

    Conserved Domains (3) summary
    cl21453
    Location:326
    PKc_like; Protein Kinases, catalytic domain
    cl25602
    Location:37121
    DUF3552; Domain of unknown function (DUF3552)
    cl26464
    Location:254597
    Atrophin-1; Atrophin-1 family
  4. XM_006723223.3XP_006723286.1  mitogen-activated protein kinase kinase kinase 10 isoform X4

    Conserved Domains (1) summary
    PHA03247
    Location:158501
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_001753691.1 RNA Sequence

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