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Aak1 AP2 associated kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 269774, updated on 2-Nov-2024

Summary

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Official Symbol
Aak1provided by MGI
Official Full Name
AP2 associated kinase 1provided by MGI
Primary source
MGI:MGI:1098687
See related
Ensembl:ENSMUSG00000057230 AllianceGenome:MGI:1098687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm38495; mKIAA1048; 9630042K20; D6Ertd245e; 5530400K14Rik
Summary
Predicted to enable AP-2 adaptor complex binding activity; Notch binding activity; and protein serine/threonine kinase activity. Involved in presynaptic endocytosis. Predicted to be located in several cellular components, including clathrin-coated pit; clathrin-coated vesicle; and terminal bouton. Predicted to be part of clathrin complex. Predicted to be active in calyx of Held. Is expressed in cranial ganglion; dorsal root ganglion; retina nuclear layer; and telencephalon. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 16.3), cortex adult (RPKM 15.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Aak1 in Genome Data Viewer
Location:
6 D1; 6 37.75 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86826252..86980209)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86849274..87003227)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene germ cell-less, spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E3661 Neighboring gene annexin A4 Neighboring gene STARR-seq mESC enhancer starr_16540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86774247-86774356 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6451 Neighboring gene STARR-positive B cell enhancer ABC_E9670 Neighboring gene STARR-positive B cell enhancer ABC_E8113 Neighboring gene STARR-seq mESC enhancer starr_16545 Neighboring gene STARR-positive B cell enhancer ABC_E6452 Neighboring gene NFU1 iron-sulfur cluster scaffold Neighboring gene STARR-seq mESC enhancer starr_16547 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:87025148-87025378 Neighboring gene glutamine fructose-6-phosphate transaminase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel AP-2 adaptor interaction motif initially identified in the long-splice isoform of synaptojanin 1, SJ170. Jha A, et al. J Biol Chem, 2004 Jan 16. PMID 14565955
  2. Periodic Variation of AAK1 in an Aβ(1-42)-Induced Mouse Model of Alzheimer's Disease. Fu X, et al. J Mol Neurosci, 2018 Jun. PMID 29774516
  3. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33376223, Free PMC Article
  4. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article
  5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40785

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AP-2 adaptor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables AP-2 adaptor complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Notch binding ISO
Inferred from Sequence Orthology
more info
  
enables Notch binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in presynaptic endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of clathrin-dependent endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of clathrin complex ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated pit ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in clathrin-coated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
AP2-associated protein kinase 1
Names
adaptor-associated kinase 1
NP_001035195.1
NP_001365581.1
NP_001365583.1
NP_001365584.1
NP_808430.2
XP_006506255.1
XP_017177086.1
XP_030111273.1
XP_030111275.1
XP_030111276.1
XP_030111278.1
XP_036022028.1
XP_036022029.1
XP_036022030.1
XP_036022031.1
XP_036022032.1
XP_036022033.1
XP_036022034.1
XP_036022035.1
XP_036022036.1
XP_036022037.1
XP_036022038.1
XP_036022039.1
XP_036022040.1
XP_036022041.1
XP_036022042.1
XP_036022043.1
XP_036022044.1
XP_036022045.1
XP_036022046.1
XP_036022047.1
XP_036022048.1
XP_036022049.1
XP_036022050.1
XP_036022051.1
XP_036022052.1
XP_036022053.1
XP_036022054.1
XP_036022055.1
XP_036022056.1
XP_036022057.1
XP_036022058.1
XP_036022059.1
XP_036022060.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040106.3 → NP_001035195.1  AP2-associated protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_001035195.1

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC159712
    Consensus CDS
    CCDS39544.1
    UniProtKB/Swiss-Prot
    B2RUJ0, Q3TY53, Q3UHJ0, Q6ZPZ6, Q80XP6
    Related
    ENSMUSP00000086948.7, ENSMUST00000089519.13
    Conserved Domains (2) summary
    smart00220
    Location:47 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  2. NM_001378652.1 → NP_001365581.1  AP2-associated protein kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC159712
    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:910 → 1122
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  3. NM_001378654.1 → NP_001365583.1  AP2-associated protein kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC159712
    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:910 → 1122
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  4. NM_001378655.1 → NP_001365584.1  AP2-associated protein kinase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC159712
    Conserved Domains (4) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 541
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:829 → 1041
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  5. NM_177762.7 → NP_808430.2  AP2-associated protein kinase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157099, AC159712
    Consensus CDS
    CCDS20317.1
    UniProtKB/Swiss-Prot
    Q3UHJ0
    Related
    ENSMUSP00000003710.10, ENSMUST00000003710.10
    Conserved Domains (2) summary
    smart00220
    Location:47 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    86826252..86980209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166138.1 → XP_036022031.1  AP2-associated protein kinase 1 isoform X1

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1085 → 1297
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  2. XM_036166152.1 → XP_036022045.1  AP2-associated protein kinase 1 isoform X13

    Conserved Domains (4) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 541
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:971 → 1183
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  3. XM_036166137.1 → XP_036022030.1  AP2-associated protein kinase 1 isoform X1

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1085 → 1297
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  4. XM_036166157.1 → XP_036022050.1  AP2-associated protein kinase 1 isoform X17

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:942 → 1154
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  5. XM_036166163.1 → XP_036022056.1  AP2-associated protein kinase 1 isoform X22

    Conserved Domains (4) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 541
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:829 → 1041
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  6. XM_036166165.1 → XP_036022058.1  AP2-associated protein kinase 1 isoform X27

    Conserved Domains (3) summary
    PHA03247
    Location:320 → 693
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  7. XM_030255418.2 → XP_030111278.1  AP2-associated protein kinase 1 isoform X31

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 541
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  8. XM_036166136.1 → XP_036022029.1  AP2-associated protein kinase 1 isoform X1

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1085 → 1297
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  9. XM_036166149.1 → XP_036022042.1  AP2-associated protein kinase 1 isoform X10

    Conserved Domains (4) summary
    PHA03247
    Location:320 → 693
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:977 → 1189
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  10. XM_036166146.1 → XP_036022039.1  AP2-associated protein kinase 1 isoform X8

    Conserved Domains (4) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 542
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1004 → 1216
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  11. XM_036166139.1 → XP_036022032.1  AP2-associated protein kinase 1 isoform X2

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1084 → 1296
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  12. XM_006506192.3 → XP_006506255.1  AP2-associated protein kinase 1 isoform X24

    Conserved Domains (2) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  13. XM_036166135.1 → XP_036022028.1  AP2-associated protein kinase 1 isoform X1

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1085 → 1297
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  14. XM_036166144.1 → XP_036022037.1  AP2-associated protein kinase 1 isoform X7

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1011 → 1223
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  15. XM_036166141.1 → XP_036022034.1  AP2-associated protein kinase 1 isoform X4

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1051 → 1263
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  16. XM_036166148.1 → XP_036022041.1  AP2-associated protein kinase 1 isoform X10

    Conserved Domains (4) summary
    PHA03247
    Location:320 → 693
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:977 → 1189
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  17. XM_036166155.1 → XP_036022048.1  AP2-associated protein kinase 1 isoform X16

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:943 → 1155
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  18. XM_036166140.1 → XP_036022033.1  AP2-associated protein kinase 1 isoform X3

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1053 → 1265
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  19. XM_036166143.1 → XP_036022036.1  AP2-associated protein kinase 1 isoform X6

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1019 → 1231
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  20. XM_036166153.1 → XP_036022046.1  AP2-associated protein kinase 1 isoform X14

    Conserved Domains (4) summary
    PHA03247
    Location:320 → 693
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:945 → 1157
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  21. XM_036166158.1 → XP_036022051.1  AP2-associated protein kinase 1 isoform X18

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:911 → 1123
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  22. XM_030255416.2 → XP_030111276.1  AP2-associated protein kinase 1 isoform X27

    Conserved Domains (3) summary
    PHA03247
    Location:320 → 693
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  23. XM_030255413.2 → XP_030111273.1  AP2-associated protein kinase 1 isoform X25

    Conserved Domains (3) summary
    PHA03247
    Location:320 → 693
    PHA03247; large tegument protein UL36; Provisional
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  24. XM_036166147.1 → XP_036022040.1  AP2-associated protein kinase 1 isoform X9

    Conserved Domains (4) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 541
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1003 → 1215
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  25. XM_017321597.2 → XP_017177086.1  AP2-associated protein kinase 1 isoform X29

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 541
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  26. XM_036166151.1 → XP_036022044.1  AP2-associated protein kinase 1 isoform X12

    Conserved Domains (4) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 542
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:972 → 1184
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  27. XM_036166145.1 → XP_036022038.1  AP2-associated protein kinase 1 isoform X8

    Conserved Domains (4) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 542
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1004 → 1216
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  28. XM_036166160.1 → XP_036022053.1  AP2-associated protein kinase 1 isoform X20

    Conserved Domains (4) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 542
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:862 → 1074
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  29. XM_036166159.1 → XP_036022052.1  AP2-associated protein kinase 1 isoform X19

    Conserved Domains (4) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 542
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:864 → 1076
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  30. XM_036166167.1 → XP_036022060.1  AP2-associated protein kinase 1 isoform X30

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    PRK10263
    Location:335 → 542
    PRK10263; DNA translocase FtsK; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  31. XM_036166162.1 → XP_036022055.1  AP2-associated protein kinase 1 isoform X21

    Conserved Domains (3) summary
    PHA03247
    Location:91 → 464
    PHA03247; large tegument protein UL36; Provisional
    pfam15282
    Location:856 → 1068
    BMP2K_C; BMP-2-inducible protein kinase C-terminus
    cl21453
    Location:1 → 87
    PKc_like; Protein Kinases, catalytic domain

  32. XM_036166142.1 → XP_036022035.1  AP2-associated protein kinase 1 isoform X5

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:1050 → 1262
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  33. XM_036166150.1 → XP_036022043.1  AP2-associated protein kinase 1 isoform X11

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:976 → 1188
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  34. XM_036166156.1 → XP_036022049.1  AP2-associated protein kinase 1 isoform X17

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:942 → 1154
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  35. XM_036166154.1 → XP_036022047.1  AP2-associated protein kinase 1 isoform X15

    Conserved Domains (3) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:944 → 1156
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

  36. XM_036166161.1 → XP_036022054.1  AP2-associated protein kinase 1 isoform X21

    Conserved Domains (3) summary
    PHA03247
    Location:91 → 464
    PHA03247; large tegument protein UL36; Provisional
    pfam15282
    Location:856 → 1068
    BMP2K_C; BMP-2-inducible protein kinase C-terminus
    cl21453
    Location:1 → 87
    PKc_like; Protein Kinases, catalytic domain

  37. XM_036166164.1 → XP_036022057.1  AP2-associated protein kinase 1 isoform X23

    Conserved Domains (2) summary
    pfam15282
    Location:775 → 987
    BMP2K_C; BMP-2-inducible protein kinase C-terminus
    cl21453
    Location:1 → 87
    PKc_like; Protein Kinases, catalytic domain

  38. XM_030255415.2 → XP_030111275.1  AP2-associated protein kinase 1 isoform X26

    Conserved Domains (2) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

  39. XM_036166166.1 → XP_036022059.1  AP2-associated protein kinase 1 isoform X28

    Conserved Domains (2) summary
    PHA03378
    Location:296 → 429
    PHA03378; EBNA-3B; Provisional
    cd14037
    Location:42 → 316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHJ0.2 GenPept UniProtKB/Swiss-Prot:Q3UHJ0
Q6PIU9.2 GenPept UniProtKB/Swiss-Prot:Q6PIU9

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