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Aak1 AP2 associated kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 269774, updated on 31-Jan-2019

Summary

Official Symbol
Aak1provided by MGI
Official Full Name
AP2 associated kinase 1provided by MGI
Primary source
MGI:MGI:1098687
See related
Ensembl:ENSMUSG00000057230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C79663; R75501; AU067724; AU067726; BC028270; mKIAA1048; 9630042K20; D6Ertd245e; 5530400K14Rik
Expression
Broad expression in cerebellum adult (RPKM 16.3), cortex adult (RPKM 15.4) and 24 other tissues See more
Orthologs

Genomic context

See Aak1 in Genome Data Viewer
Location:
6 D1; 6 37.75 cM
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (86849482..87003227)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (86799511..86953221)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene annexin A4 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene predicted gene, 38495 Neighboring gene NFU1 iron-sulfur cluster scaffold Neighboring gene glutamine fructose-6-phosphate transaminase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40785

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
 
Notch binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
clathrin complex ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynapse ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
AP2 associated kinase 1
Names
adaptor-associated kinase 1
NP_001035195.1
NP_808430.2
XP_006506254.1
XP_006506255.1
XP_017177086.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040106.2NP_001035195.1  AP2 associated kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_001035195.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC157099, AC159712, AK147363, BP753891, CA528349
    Consensus CDS
    CCDS39544.1
    UniProtKB/Swiss-Prot
    Q3UHJ0
    Related
    ENSMUSP00000086948.6, ENSMUST00000089519.12
    Conserved Domains (2) summary
    smart00220
    Location:47307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
  2. NM_177762.6NP_808430.2  AP2 associated kinase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter when compared to isoform 1.
    Source sequence(s)
    AC159712, AK147363, AK158879, BC043125, BP753891, CF723295
    Consensus CDS
    CCDS20317.1
    UniProtKB/Swiss-Prot
    Q3UHJ0
    Related
    ENSMUSP00000003710.9, ENSMUST00000003710.9
    Conserved Domains (2) summary
    smart00220
    Location:47307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    86849482..87003227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506191.1XP_006506254.1  AP2 associated kinase 1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:47307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
  2. XM_006506192.1XP_006506255.1  AP2 associated kinase 1 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:47307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
  3. XM_017321597.1XP_017177086.1  AP2 associated kinase 1 isoform X3

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