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Cul1 cullin 1 [ Mus musculus (house mouse) ]

Gene ID: 26965, updated on 8-Feb-2024

Summary

Official Symbol
Cul1provided by MGI
Official Full Name
cullin 1provided by MGI
Primary source
MGI:MGI:1349658
See related
Ensembl:ENSMUSG00000029686 AllianceGenome:MGI:1349658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cul-1
Summary
Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Predicted to contribute to ubiquitin protein ligase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including animal organ morphogenesis; apoptotic process; and protein ubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including adrenal gland; genitourinary system; immune system; neural retina; and telencephalon. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.9), bladder adult (RPKM 24.8) and 28 other tissues See more
Orthologs
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Genomic context

See Cul1 in Genome Data Viewer
Location:
6 B2.3; 6 22.9 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47430516..47503078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47453732..47526144)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene contactin associated protein-like 2 Neighboring gene STARR-seq mESC enhancer starr_15777 Neighboring gene predicted gene, 53327 Neighboring gene STARR-seq mESC enhancer starr_15778 Neighboring gene RIKEN cDNA F830010H11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:47544952-47545253 Neighboring gene STARR-seq mESC enhancer starr_15780 Neighboring gene STARR-seq mESC enhancer starr_15781 Neighboring gene STARR-positive B cell enhancer ABC_E4823 Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene predicted gene, 40371 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin ligase complex scaffold activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin protein ligase activity IC
Inferred by Curator
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein monoubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355550.2NP_001342479.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    Consensus CDS
    CCDS20095.1
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:706767
    Cullin_Nedd8; Cullin protein neddylation domain
  2. NM_001355551.2NP_001342480.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    Consensus CDS
    CCDS20095.1
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
    Related
    ENSMUSP00000122702.2, ENSMUST00000146200.8
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:706767
    Cullin_Nedd8; Cullin protein neddylation domain
  3. NM_001410599.1NP_001397528.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
  4. NM_001410600.1NP_001397529.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
  5. NM_001410601.1NP_001397530.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
  6. NM_001410602.1NP_001397531.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
  7. NM_012042.5NP_036172.1  cullin-1

    See identical proteins and their annotated locations for NP_036172.1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    Consensus CDS
    CCDS20095.1
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
    Related
    ENSMUSP00000031697.9, ENSMUST00000031697.9
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:706767
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    47430516..47503078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)