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Cul1 cullin 1 [ Mus musculus (house mouse) ]

Gene ID: 26965, updated on 9-Sep-2018

Summary

Official Symbol
Cul1provided by MGI
Official Full Name
cullin 1provided by MGI
Primary source
MGI:MGI:1349658
See related
Ensembl:ENSMUSG00000029686 Vega:OTTMUSG00000022333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cul-1
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.9), bladder adult (RPKM 24.8) and 28 other tissues See more
Orthologs

Genomic context

See Cul1 in Genome Data Viewer
Location:
6; 6 B2.3
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (47453737..47526139)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (47404323..47476138)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene contactin associated protein-like 2 Neighboring gene predicted gene, 35280 Neighboring gene predicted gene, 35565 Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene predicted gene, 40371 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ubiquitin protein ligase activity IC
Inferred by Curator
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein monoubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355550.1NP_001342479.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    Conserved Domains (2) summary
    smart00884
    Location:703770
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:22660
    Cullin; Cullin family
  2. NM_001355551.1NP_001342480.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    Conserved Domains (2) summary
    smart00884
    Location:703770
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:22660
    Cullin; Cullin family
  3. NM_012042.4NP_036172.1  cullin-1

    See identical proteins and their annotated locations for NP_036172.1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    Consensus CDS
    CCDS20095.1
    UniProtKB/Swiss-Prot
    Q9WTX6
    Related
    ENSMUSP00000031697.8, OTTMUSP00000025305, ENSMUST00000031697.8
    Conserved Domains (2) summary
    smart00884
    Location:703770
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:22660
    Cullin; Cullin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    47453737..47526139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506188.3XP_006506251.1  cullin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q9WTX6
    Related
    ENSMUSP00000122702.1, OTTMUSP00000025306, ENSMUST00000146200.7, OTTMUST00000053241
    Conserved Domains (2) summary
    smart00884
    Location:703770
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:22660
    Cullin; Cullin family
  2. XM_006506189.3XP_006506252.1  cullin-1 isoform X1

    See identical proteins and their annotated locations for XP_006506252.1

    UniProtKB/Swiss-Prot
    Q9WTX6
    Conserved Domains (2) summary
    smart00884
    Location:703770
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:22660
    Cullin; Cullin family
  3. XM_006506190.3XP_006506253.1  cullin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q9WTX6
    Conserved Domains (2) summary
    smart00884
    Location:703770
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:22660
    Cullin; Cullin family
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