Cul1 cullin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cul1provided by MGI
Official Full Name: cullin 1provided by MGI
Primary source: MGI:MGI:1349658
See related: Ensembl:ENSMUSG00000029686 Vega:OTTMUSG00000022333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cul-1
Expression: Ubiquitous expression in CNS E11.5 (RPKM 25.9), bladder adult (RPKM 24.8) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 6; 6 B2.3

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	6	NC_000072.6 (47453737..47526139)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	6	NC_000072.5 (47404323..47476138)

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Cul-1 deneddylation led to Deptor accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
Title: Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation.
Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
Title: Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Title: Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
Analysis of cell cycle regulatory genes reveals defective induction of the c-Myc:CUL1 ubiquitin ligase pathway in B cells from CD22-deficient mice in the context of a C57BL/6 genetic background, following IgM ligation compared with wild-type B cells.
Title: Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
Skp2 and Cul1 expression is repressed by GATA2, thereby inhibiting ubiquitin/proteasome-dependent degradation of p21(WAF1) and p27(Kip1), inducing their accumulation, and suppressing hematopoietic stem cell growth
Title: GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21(WAF1) and p27(Kip1) proteins.
Cul7 forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8.
Title: Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Pathways from BioSystems

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APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of NF-kappaB in B cells, organism-specific biosystem (from REACTOME)
Activation of NF-kappaB in B cells, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
C-type lectin receptors (CLRs), organism-specific biosystemcomputationally inferred pathway (not manually curated)
CLEC7A (Dectin-1) signaling, organism-specific biosystem (from REACTOME)
CLEC7A (Dectin-1) signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Circadian rhythm, organism-specific biosystem (from KEGG)
Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
Circadian rhythm, conserved biosystem (from KEGG)
Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
Class I MHC mediated antigen processing & presentation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
Cyclin D associated events in G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
Cyclin E associated events during G1/S transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dectin-1 mediated noncanonical NF-kB signaling, organism-specific biosystem (from REACTOME)
Dectin-1 mediated noncanonical NF-kB signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of GLI1 by the proteasome, organism-specific biosystem (from REACTOME)
Degradation of GLI1 by the proteasome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
Degradation of beta-catenin by the destruction complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Downstream TCR signaling, organism-specific biosystem (from REACTOME)
Downstream TCR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, organism-specific biosystem (from REACTOME)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FCERI mediated NF-kB activation, organism-specific biosystem (from REACTOME)
FCERI mediated NF-kB activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
Fc epsilon receptor (FCERI) signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1 Phase, organism-specific biosystem (from REACTOME)
G1 Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M Transition, organism-specific biosystem (from REACTOME)
G2/M Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GLI3 is processed to GLI3R by the proteasome, organism-specific biosystem (from REACTOME)
GLI3 is processed to GLI3R by the proteasome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hedgehog 'off' state, organism-specific biosystem (from REACTOME)
Hedgehog 'off' state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
Hedgehog signaling pathway, conserved biosystem (from KEGG)
Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
Interleukin-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
MAP kinase activation in TLR cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAP3K8 (TPL2)-dependent MAPK1/3 activation, organism-specific biosystem (from REACTOME)
MAP3K8 (TPL2)-dependent MAPK1/3 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
Mitotic G2-G2/M phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88 cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
MyD88 dependent cascade initiated on endosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NIK-->noncanonical NF-kB signaling, organism-specific biosystem (from REACTOME)
NIK-->noncanonical NF-kB signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Oocyte meiosis, organism-specific biosystem (from KEGG)
Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Oocyte meiosis, conserved biosystem (from KEGG)
Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Prolactin receptor signaling, organism-specific biosystem (from REACTOME)
Prolactin receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SCF-BTRC complex, organism-specific biosystem (from KEGG)
SCF-BTRC complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-BTRC complex, conserved biosystem (from KEGG)
SCF-BTRC complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-FBS complex, organism-specific biosystem (from KEGG)
SCF-FBS complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-FBS complex, conserved biosystem (from KEGG)
SCF-FBS complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-FBW7 complex, organism-specific biosystem (from KEGG)
SCF-FBW7 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-FBW7 complex, conserved biosystem (from KEGG)
SCF-FBW7 complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-SKP2 complex, organism-specific biosystem (from KEGG)
SCF-SKP2 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-SKP2 complex, conserved biosystem (from KEGG)
SCF-SKP2 complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystem (from REACTOME)
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
Signaling by Hedgehog, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Wnt, organism-specific biosystem (from REACTOME)
Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
TCR signaling, organism-specific biosystem (from REACTOME)
TCR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TGF-beta signaling pathway, conserved biosystem (from KEGG)
TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
TNF-alpha NF-kB Signaling Pathway
TNFR2 non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
TNFR2 non-canonical NF-kB pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW743318 (e-PCR)
- UniSTS:207945

D6Mit352 (e-PCR), detects polymorphism
- UniSTS:130903

D6Dcr7 (e-PCR), detects polymorphism
- UniSTS:507762

MHAa27b4.seq (e-PCR)
- UniSTS:125102

Homology

Homologs of the Cul1 gene: The Cul1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 238 organisms have orthologs with human gene Cul1
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to ubiquitin protein ligase activity	IC Inferred by Curator more info	PubMed
ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
protein monoubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
protein ubiquitination	ISO Inferred from Sequence Orthology more info
ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
viral process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
cullin-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cullin-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cullin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355550.1 → NP_001342479.1 cullin-1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

Conserved Domains (2) summary

smart00884
Location:703 → 770

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:22 → 660

Cullin; Cullin family
NM_001355551.1 → NP_001342480.1 cullin-1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

Conserved Domains (2) summary

smart00884
Location:703 → 770

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:22 → 660

Cullin; Cullin family
NM_012042.4 → NP_036172.1 cullin-1

See identical proteins and their annotated locations for NP_036172.1

Status: VALIDATED

Source sequence(s)

AC154014, AC154015

Consensus CDS

CCDS20095.1

UniProtKB/Swiss-Prot

Q9WTX6

Related

ENSMUSP00000031697.8, OTTMUSP00000025305, ENSMUST00000031697.8

Conserved Domains (2) summary

smart00884
Location:703 → 770

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:22 → 660

Cullin; Cullin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38.p4 C57BL/6J

Range

47453737..47526139

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506188.3 → XP_006506251.1 cullin-1 isoform X1

UniProtKB/Swiss-Prot

Q9WTX6

Related

ENSMUSP00000122702.1, OTTMUSP00000025306, ENSMUST00000146200.7, OTTMUST00000053241

Conserved Domains (2) summary

smart00884
Location:703 → 770

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:22 → 660

Cullin; Cullin family
XM_006506189.3 → XP_006506252.1 cullin-1 isoform X1

See identical proteins and their annotated locations for XP_006506252.1

UniProtKB/Swiss-Prot

Q9WTX6

Conserved Domains (2) summary

smart00884
Location:703 → 770

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:22 → 660

Cullin; Cullin family
XM_006506190.3 → XP_006506253.1 cullin-1 isoform X1

UniProtKB/Swiss-Prot

Q9WTX6

Conserved Domains (2) summary

smart00884
Location:703 → 770

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:22 → 660

Cullin; Cullin family