Format

Send to:

Choose Destination

CUL1 cullin 1 [ Homo sapiens (human) ]

Gene ID: 8454, updated on 20-Sep-2020

Summary

Official Symbol
CUL1provided by HGNC
Official Full Name
cullin 1provided by HGNC
Primary source
HGNC:HGNC:2551
See related
Ensembl:ENSG00000055130 MIM:603134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 55.7), lymph node (RPKM 17.7) and 24 other tissues See more
Orthologs

Genomic context

See CUL1 in Genome Data Viewer
Location:
7q36.1
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (148697756..148801110)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148395631..148498202)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein K pseudogene Neighboring gene acyl-CoA thioesterase 13 pseudogene Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene RNA, U7 small nuclear 20 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 569, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with Cullin 1 (CUL1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149834, MGC149835

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
SCF complex assembly TAS
Traceable Author Statement
more info
 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular iron ion homeostasis TAS
Traceable Author Statement
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cullin-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065171.1 RefSeqGene

    Range
    6148..108355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370660.1NP_001357589.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Related
    ENSP00000499277.1, ENST00000662716.1
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:708767
    Cullin_Nedd8; Cullin protein neddylation domain
  2. NM_001370661.1NP_001357590.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Related
    ENSP00000499255.1, ENST00000665936.1
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:708767
    Cullin_Nedd8; Cullin protein neddylation domain
  3. NM_001370662.1NP_001357591.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Related
    ENSP00000473318.1, ENST00000602748.5
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:708767
    Cullin_Nedd8; Cullin protein neddylation domain
  4. NM_001370663.1NP_001357592.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Related
    ENSP00000499398.1, ENST00000663044.1
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:708767
    Cullin_Nedd8; Cullin protein neddylation domain
  5. NM_001370664.1NP_001357593.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:708767
    Cullin_Nedd8; Cullin protein neddylation domain
  6. NM_003592.3NP_003583.2  cullin-1

    See identical proteins and their annotated locations for NP_003583.2

    Status: REVIEWED

    Source sequence(s)
    AF062536, AK096163, CA945052
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    Q13616
    UniProtKB/TrEMBL
    A0A090N7U0, B3KTW0
    Related
    ENSP00000326804.3, ENST00000325222.9
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:708767
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    148697756..148801110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center