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CUL1 cullin 1 [ Homo sapiens (human) ]

Gene ID: 8454, updated on 4-Jun-2023

Summary

Official Symbol
CUL1provided by HGNC
Official Full Name
cullin 1provided by HGNC
Primary source
HGNC:HGNC:2551
See related
Ensembl:ENSG00000055130 MIM:603134; AllianceGenome:HGNC:2551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 55.7), lymph node (RPKM 17.7) and 24 other tissues See more
Orthologs
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Genomic context

See CUL1 in Genome Data Viewer
Location:
7q36.1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (148697756..148801110)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (149879652..149982884)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148394848..148498202)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein K pseudogene Neighboring gene acyl-CoA thioesterase 13 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148396297-148397022 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:148469244-148470443 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148479522-148480224 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148480425-148481624 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148495129-148496328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148504832-148505332 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene RNA, U7 small nuclear 20 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with Cullin 1 (CUL1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC149834, MGC149835

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin ligase complex scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of cullin-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065171.1 RefSeqGene

    Range
    6148..108355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1407

mRNA and Protein(s)

  1. NM_001370660.1NP_001357589.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0
    Related
    ENSP00000499277.1, ENST00000662716.1
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:706767
    Cullin_Nedd8; Cullin protein neddylation domain
  2. NM_001370661.1NP_001357590.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0
    Related
    ENSP00000499255.1, ENST00000665936.1
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:706767
    Cullin_Nedd8; Cullin protein neddylation domain
  3. NM_001370662.1NP_001357591.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0
    Related
    ENSP00000473318.1, ENST00000602748.5
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:706767
    Cullin_Nedd8; Cullin protein neddylation domain
  4. NM_001370663.1NP_001357592.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0
    Related
    ENSP00000499398.1, ENST00000663044.1
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:706767
    Cullin_Nedd8; Cullin protein neddylation domain
  5. NM_001370664.1NP_001357593.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:706767
    Cullin_Nedd8; Cullin protein neddylation domain
  6. NM_003592.3NP_003583.2  cullin-1

    See identical proteins and their annotated locations for NP_003583.2

    Status: REVIEWED

    Source sequence(s)
    AF062536, AK096163, CA945052
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    Q13616, Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0, B3KTW0
    Related
    ENSP00000326804.3, ENST00000325222.9
    Conserved Domains (2) summary
    pfam00888
    Location:21660
    Cullin; Cullin family
    pfam10557
    Location:706767
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    148697756..148801110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    149879652..149982884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)