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Plch2 phospholipase C, eta 2 [ Mus musculus (house mouse) ]

Gene ID: 269615, updated on 18-Apr-2024

Summary

Official Symbol
Plch2provided by MGI
Official Full Name
phospholipase C, eta 2provided by MGI
Primary source
MGI:MGI:2443078
See related
Ensembl:ENSMUSG00000029055 AllianceGenome:MGI:2443078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plcl4; PLCeta2; Plc-eta2; A930027K05Rik
Summary
Enables phospholipase C activity. Acts upstream of or within phosphatidylinositol metabolic process. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; integumental system; lower urinary tract; and sensory organ. Orthologous to human PLCH2 (phospholipase C eta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 24.6), colon adult (RPKM 15.7) and 14 other tissues See more
Orthologs
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Genomic context

Location:
4 E2; 4 86.13 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155067572..155148548, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154983115..155064091, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8040 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene pantothenate kinase 4 Neighboring gene STARR-positive B cell enhancer ABC_E10295 Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene STARR-positive B cell enhancer ABC_E1295 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene MORN repeat containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphatidylinositol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
Names
phosphoinositide phospholipase C-eta-2
phosphoinositide phospholipase C-like 4
phospholipase C-like protein 4
NP_001106831.1
NP_001343399.1
NP_780765.2
XP_006538999.1
XP_006539003.1
XP_011248570.1
XP_011248571.1
XP_011248572.1
XP_011248573.1
XP_011248574.1
XP_011248575.1
XP_011248576.1
XP_011248577.1
XP_011248578.1
XP_017175736.1
XP_036020059.1
XP_036020060.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113360.3NP_001106831.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b

    See identical proteins and their annotated locations for NP_001106831.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (b).
    Source sequence(s)
    AL831788, BX004788
    Consensus CDS
    CCDS71533.1
    UniProtKB/Swiss-Prot
    A2AP18, A6PWW5, Q3LUA7, Q4QSC7, Q80WP6, Q8BJV1, Q8BWU4, Q8BXN5, Q8CFR1
    UniProtKB/TrEMBL
    H3BK11
    Related
    ENSMUSP00000101256.3, ENSMUST00000105631.9
    Conserved Domains (8) summary
    cd00275
    Location:838963
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:399808
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02952
    Location:316948
    PLN02952; phosphoinositide phospholipase C
    cd00051
    Location:247313
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd13364
    Location:123229
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam00169
    Location:141229
    PH; PH domain
    pfam09279
    Location:317399
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:248309
    EF-hand_7; EF-hand domain pair
  2. NM_001356470.1NP_001343399.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AK044619, AL831788, BC052329, BC060083, BX004788, CJ113070, DQ176851
    UniProtKB/TrEMBL
    H3BIW6
    Related
    ENSMUSP00000134750.2, ENSMUST00000176194.8
    Conserved Domains (6) summary
    cd08633
    Location:318727
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:22128
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:146175
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:9161092
    Atrophin-1; Atrophin-1 family
    cl27705
    Location:288867
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
    cl28895
    Location:146306
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  3. NM_175556.5NP_780765.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform a

    See identical proteins and their annotated locations for NP_780765.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site and contains an alternate exon in the 3' coding region, resulting in an early stop codon, compared to variant 1. It encodes isoform a, which is shorter and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AL831788, BX004788
    Consensus CDS
    CCDS38990.2
    UniProtKB/TrEMBL
    F7C3A0, F8VQ50, H3BIW6
    Related
    ENSMUSP00000122704.3, ENSMUST00000139976.9
    Conserved Domains (8) summary
    cd00275
    Location:838963
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:399808
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02952
    Location:316948
    PLN02952; phosphoinositide phospholipase C
    cd00051
    Location:247313
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd13364
    Location:123229
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam00169
    Location:141229
    PH; PH domain
    pfam09279
    Location:317399
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:248309
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155067572..155148548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250270.1XP_011248572.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

    See identical proteins and their annotated locations for XP_011248572.1

    Conserved Domains (6) summary
    cd08633
    Location:336745
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:306885
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:9341426
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:40146
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:164193
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:164324
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  2. XM_011250271.4XP_011248573.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

    See identical proteins and their annotated locations for XP_011248573.1

    Conserved Domains (6) summary
    cd08633
    Location:336745
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:306885
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:9341426
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:40146
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:164193
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:164324
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  3. XM_006538940.2XP_006539003.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X7

    Related
    ENSMUSP00000118292.3, ENSMUST00000135665.9
    Conserved Domains (5) summary
    cd08633
    Location:469878
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:3911018
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:10651391
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:317457
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
  4. XM_036164167.1XP_036020060.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X12

    UniProtKB/TrEMBL
    H3BIW6
    Conserved Domains (4) summary
    cd08633
    Location:469878
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:3911018
    PLN02228; Phosphoinositide phospholipase C
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:317457
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
  5. XM_006538936.2XP_006538999.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2

    Conserved Domains (5) summary
    cd08633
    Location:469878
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:3911018
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:10671559
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:317457
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
  6. XM_017320247.1XP_017175736.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X9

    UniProtKB/TrEMBL
    H3BIW6
    Conserved Domains (5) summary
    cd08633
    Location:469878
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:3911018
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:10671243
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:317457
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
  7. XM_011250272.1XP_011248574.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X5

    Conserved Domains (6) summary
    cd08633
    Location:489898
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:4591038
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:10851411
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:317346
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:317477
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  8. XM_011250276.2XP_011248578.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X11

    UniProtKB/TrEMBL
    H3BIW6
    Conserved Domains (5) summary
    cd08633
    Location:489898
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:4591038
    PLN02228; Phosphoinositide phospholipase C
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:317346
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:317477
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  9. XM_036164166.1XP_036020059.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X11

    UniProtKB/TrEMBL
    H3BIW6
    Conserved Domains (5) summary
    cd08633
    Location:489898
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:4591038
    PLN02228; Phosphoinositide phospholipase C
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:317346
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:317477
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  10. XM_011250268.1XP_011248570.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1

    Conserved Domains (6) summary
    cd08633
    Location:489898
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:4591038
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:10871579
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:317346
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:317477
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  11. XM_011250274.2XP_011248576.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X8

    UniProtKB/TrEMBL
    H3BIW6
    Conserved Domains (6) summary
    cd08633
    Location:489898
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:4591038
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:10871263
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:317346
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:317477
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  12. XM_011250269.2XP_011248571.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

    Conserved Domains (6) summary
    cd08633
    Location:341750
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:311890
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:9391431
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:45151
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:169198
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:169329
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  13. XM_011250273.3XP_011248575.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X6

    Conserved Domains (6) summary
    cd08633
    Location:318727
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:288867
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:9161408
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:22128
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:146175
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:146306
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  14. XM_011250275.2XP_011248577.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X10

    Conserved Domains (5) summary
    cd08633
    Location:489898
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:4591038
    PLN02228; Phosphoinositide phospholipase C
    cd13364
    Location:193299
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:317346
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:317477
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

RNA

  1. XR_004941911.1 RNA Sequence

  2. XR_004941914.1 RNA Sequence

  3. XR_004941913.1 RNA Sequence

  4. XR_001784150.1 RNA Sequence

  5. XR_004941912.1 RNA Sequence

  6. XR_881430.1 RNA Sequence