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Clspn claspin [ Mus musculus (house mouse) ]

Gene ID: 269582, updated on 8-Feb-2024

Summary

Official Symbol
Clspnprovided by MGI
Official Full Name
claspinprovided by MGI
Primary source
MGI:MGI:2445153
See related
Ensembl:ENSMUSG00000042489 AllianceGenome:MGI:2445153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B130025E01; E130314M08Rik
Summary
Predicted to enable DNA secondary structure binding activity and anaphase-promoting complex binding activity. Predicted to be involved in activation of protein kinase activity; mitotic G2/M transition checkpoint; and peptidyl-serine phosphorylation. Predicted to act upstream of or within DNA replication checkpoint signaling. Predicted to be located in Golgi apparatus and nucleoplasm. Is expressed in several structures, including adrenal medulla; brain ventricular layer; oral epithelium; reproductive system; and trunk mesenchyme derived from neural crest. Orthologous to human CLSPN (claspin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 13.6), liver E14 (RPKM 12.3) and 10 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Clspn in Genome Data Viewer
Location:
4 D2.2; 4 60.9 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126450738..126488326)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126556957..126594533)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene argonaute RISC catalytic subunit 1 Neighboring gene STARR-seq mESC enhancer starr_11403 Neighboring gene STARR-positive B cell enhancer ABC_E2714 Neighboring gene STARR-seq mESC enhancer starr_11404 Neighboring gene argonaute RISC catalytic subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E1655 Neighboring gene STARR-positive B cell enhancer mm9_chr4:126231790-126232090 Neighboring gene STARR-positive B cell enhancer ABC_E10259 Neighboring gene microRNA 7119 Neighboring gene STARR-seq mESC enhancer starr_11405 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene RIKEN cDNA 5730409E04Rik gene Neighboring gene predicted gene, 46870

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA secondary structure binding ISO
Inferred from Sequence Orthology
more info
 
enables anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables anaphase-promoting complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic DNA replication checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
claspin
Names
claspin homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405798.1NP_001392727.1  claspin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606935
  2. NM_001405799.1NP_001392728.1  claspin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606935
  3. NM_001405800.1NP_001392729.1  claspin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606935
  4. NM_001405801.1NP_001392730.1  claspin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606935
  5. NM_175554.5NP_780763.3  claspin isoform 4

    See identical proteins and their annotated locations for NP_780763.3

    Status: VALIDATED

    Source sequence(s)
    AL606935
    Consensus CDS
    CCDS18655.1
    UniProtKB/Swiss-Prot
    B1ARX6, Q69GM2, Q80YR7
    Related
    ENSMUSP00000045344.9, ENSMUST00000048391.15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    126450738..126488326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503124.4XP_006503187.1  claspin isoform X1

    See identical proteins and their annotated locations for XP_006503187.1

  2. XM_011240541.4XP_011238843.1  claspin isoform X3

    See identical proteins and their annotated locations for XP_011238843.1

    UniProtKB/Swiss-Prot
    B1ARX6, Q69GM2, Q80YR7
  3. XM_006503123.5XP_006503186.1  claspin isoform X1

    See identical proteins and their annotated locations for XP_006503186.1