Format

Send to:

Choose Destination

CLSPN claspin [ Homo sapiens (human) ]

Gene ID: 63967, updated on 14-Jun-2020

Summary

Official Symbol
CLSPNprovided by HGNC
Official Full Name
claspinprovided by HGNC
Primary source
HGNC:HGNC:19715
See related
Ensembl:ENSG00000092853 MIM:605434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Broad expression in bone marrow (RPKM 2.6), testis (RPKM 2.4) and 16 other tissues See more
Orthologs

Genomic context

See CLSPN in Genome Data Viewer
Location:
1p34.3
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (35720213..35769985, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36185819..36235568, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378646 Neighboring gene Sharpr-MPRA regulatory region 7840 Neighboring gene chromosome 1 open reading frame 216 Neighboring gene argonaute RISC component 4 Neighboring gene argonaute RISC component 1 Neighboring gene argonaute RISC catalytic component 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131612, MGC131613, MGC131615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA secondary structure binding IDA
Inferred from Direct Assay
more info
PubMed 
anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
mitotic DNA replication checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic G2 DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic G2 DNA damage checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
claspin
Names
claspin homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190481.2NP_001177410.1  claspin isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF297866, AL354864, BC115025, BC137279
    Consensus CDS
    CCDS53297.1
    UniProtKB/Swiss-Prot
    Q9HAW4
    Related
    ENSP00000362317.3, ENST00000373220.7
  2. NM_001330490.2NP_001317419.1  claspin isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL354864
    Consensus CDS
    CCDS81299.1
    UniProtKB/Swiss-Prot
    Q9HAW4
    Related
    ENSP00000251195.5, ENST00000251195.9
  3. NM_022111.4NP_071394.2  claspin isoform 1

    See identical proteins and their annotated locations for NP_071394.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF297866, AL354864, BC137279
    Consensus CDS
    CCDS396.1
    UniProtKB/Swiss-Prot
    Q9HAW4
    Related
    ENSP00000312995.3, ENST00000318121.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    35720213..35769985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541940.3XP_011540242.1  claspin isoform X2

  2. XM_011541938.2XP_011540240.1  claspin isoform X1

    Related
    ENSP00000428848.1, ENST00000520551.1
  3. XM_011541941.3XP_011540243.1  claspin isoform X3

RNA

  1. XR_001737361.2 RNA Sequence

Support Center