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Tex10 testis expressed gene 10 [ Mus musculus (house mouse) ]

Gene ID: 269536, updated on 2-Nov-2024

Summary

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Official Symbol
Tex10provided by MGI
Official Full Name
testis expressed gene 10provided by MGI
Primary source
MGI:MGI:1344413
See related
Ensembl:ENSMUSG00000028345 AllianceGenome:MGI:1344413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610206N19Rik; 2810462N03Rik
Summary
Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of MLL1 complex. Predicted to be active in nucleus. Orthologous to human TEX10 (testis expressed 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 12.4), placenta adult (RPKM 9.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Tex10 in Genome Data Viewer
Location:
4 B1; 4 26.13 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (48430805..48473492, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (48430858..48473464, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10154 Neighboring gene endoplasmic reticulum protein 44 Neighboring gene STARR-positive B cell enhancer ABC_E6176 Neighboring gene microRNA 1958 Neighboring gene STARR-positive B cell enhancer ABC_E6177 Neighboring gene STARR-seq mESC enhancer starr_10155 Neighboring gene STARR-positive B cell enhancer ABC_E1644 Neighboring gene STARR-seq mESC enhancer starr_10157 Neighboring gene inversin Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6178 Neighboring gene STARR-seq mESC enhancer starr_10161 Neighboring gene STARR-seq mESC enhancer starr_10162 Neighboring gene STARR-seq mESC enhancer starr_10163 Neighboring gene STARR-seq mESC enhancer starr_10164 Neighboring gene Myb/SANT-like DNA-binding domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_10167 Neighboring gene transmembrane protein with EGF-like and two follistatin-like domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Ding J, et al. Cell Stem Cell, 2015 Jun 4. PMID 25936917, Free PMC Article
  2. Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis. Xiang X, et al. Mol Carcinog, 2023 Dec. PMID 37792308
  3. Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse. Morgan D, et al. Nat Genet, 1998 Oct. PMID 9771707
  4. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Fanis P, et al. Mol Cell Proteomics, 2012 Nov. PMID 22872859, Free PMC Article
  5. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis.
    Title: Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis.
  2. Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC]
    Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
  3. Tex10 is a core component of the pluripotency network.
    Title: Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11792

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of MLL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testis-expressed protein 10
Names
clone 18330
testis-expressed sequence 10 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355740.1 → NP_001342669.1  testis-expressed protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK141288, CA539714, CJ082426, DV645036
    Consensus CDS
    CCDS38760.1
    UniProtKB/Swiss-Prot
    Q3URQ0
    Related
    ENSMUSP00000030030.9, ENSMUST00000030030.15
    Conserved Domains (1) summary
    pfam12333
    Location:132 → 235
    Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

  2. NM_001355741.1 → NP_001342670.1  testis-expressed protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK141288, CA539714, CJ082426, DV645036

  3. NM_172304.4 → NP_758508.2  testis-expressed protein 10 isoform 1

    See identical proteins and their annotated locations for NP_758508.2

    Status: VALIDATED

    Source sequence(s)
    AK132870, AK141288, CJ082426, DV645036
    Consensus CDS
    CCDS38760.1
    UniProtKB/Swiss-Prot
    Q3URQ0
    Related
    ENSMUSP00000132498.2, ENSMUST00000164866.2
    Conserved Domains (1) summary
    pfam12333
    Location:132 → 235
    Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    48430805..48473492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537956.4 → XP_006538019.1  testis-expressed protein 10 isoform X1

    See identical proteins and their annotated locations for XP_006538019.1

    UniProtKB/Swiss-Prot
    Q3URQ0
    Conserved Domains (1) summary
    pfam12333
    Location:132 → 235
    Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

  2. XM_036164139.1 → XP_036020032.1  testis-expressed protein 10 isoform X2

    Conserved Domains (1) summary
    pfam12333
    Location:132 → 235
    Ipi1_N; Rix1 complex component involved in 60S ribosome maturation
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3URQ0.1 GenPept UniProtKB/Swiss-Prot:Q3URQ0

Gene LinkOut

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