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Racgap1 Rac GTPase-activating protein 1 [ Mus musculus (house mouse) ]

Gene ID: 26934, updated on 18-Apr-2024

Summary

Official Symbol
Racgap1provided by MGI
Official Full Name
Rac GTPase-activating protein 1provided by MGI
Primary source
MGI:MGI:1349423
See related
Ensembl:ENSMUSG00000023015 AllianceGenome:MGI:1349423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gtl11; Band25; GTPase; MgcRacGAP; mKIAA1478
Summary
Predicted to enable several functions, including GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and tubulin binding activity. Involved in regulation of embryonic development. Acts upstream of or within neuroblast proliferation. Predicted to be located in several cellular components, including cleavage furrow; midbody; and spindle. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be part of centralspindlin complex. Is expressed in several structures, including blastocyst; central nervous system; early embryo; neural retina; and nose. Orthologous to human RACGAP1 (Rac GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 49.5), liver E14 (RPKM 31.3) and 20 other tissues See more
Orthologs
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Genomic context

Location:
15 F1; 15 56.13 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99518377..99549504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99620496..99651656, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34765 Neighboring gene aquaporin 5 Neighboring gene aquaporin 6 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99481947-99482248 Neighboring gene predicted gene, 34880 Neighboring gene acid-sensing ion channel 1 Neighboring gene STARR-seq mESC enhancer starr_39720

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actomyosin contractile ring assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle midzone assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuroblast proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in sulfate transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of centralspindlin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of centralspindlin complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rac GTPase-activating protein 1
Names
male germ cell RacGap

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253808.2NP_001240737.1  rac GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_001240737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC139317
    Consensus CDS
    CCDS27825.1
    UniProtKB/Swiss-Prot
    Q3THR5, Q3TI41, Q3TM81, Q9WVM1
    Related
    ENSMUSP00000023756.6, ENSMUST00000023756.12
    Conserved Domains (3) summary
    cd04382
    Location:347540
    RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...
    pfam00261
    Location:43108
    Tropomyosin
    cd20821
    Location:286339
    C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins
  2. NM_001253809.2NP_001240738.1  rac GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_001240738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC139317
    Consensus CDS
    CCDS27825.1
    UniProtKB/Swiss-Prot
    Q3THR5, Q3TI41, Q3TM81, Q9WVM1
    Conserved Domains (3) summary
    cd04382
    Location:347540
    RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...
    pfam00261
    Location:43108
    Tropomyosin
    cd20821
    Location:286339
    C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins
  3. NM_001411865.1NP_001398794.1  rac GTPase-activating protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC139317
    UniProtKB/Swiss-Prot
    Q3THR5, Q3TI41, Q3TM81, Q9WVM1
  4. NM_001411866.1NP_001398795.1  rac GTPase-activating protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC139317
    UniProtKB/Swiss-Prot
    Q3THR5, Q3TI41, Q3TM81, Q9WVM1
  5. NM_012025.8NP_036155.1  rac GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_036155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    AC139317
    Consensus CDS
    CCDS27825.1
    UniProtKB/Swiss-Prot
    Q3THR5, Q3TI41, Q3TM81, Q9WVM1
    Related
    ENSMUSP00000126417.2, ENSMUST00000171702.8
    Conserved Domains (3) summary
    cd04382
    Location:347540
    RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...
    pfam00261
    Location:43108
    Tropomyosin
    cd20821
    Location:286339
    C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins

RNA

  1. NR_177956.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139317
  2. NR_177957.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139317
  3. NR_177958.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139317
  4. NR_177959.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139317

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99518377..99549504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)