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RACGAP1 Rac GTPase activating protein 1 [ Homo sapiens (human) ]

Gene ID: 29127, updated on 16-Sep-2019

Summary

Official Symbol
RACGAP1provided by HGNC
Official Full Name
Rac GTPase activating protein 1provided by HGNC
Primary source
HGNC:HGNC:9804
See related
Ensembl:ENSG00000161800 MIM:604980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYK4; ID-GAP; HsCYK-4; MgcRacGAP
Summary
This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]
Expression
Broad expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 20 other tissues See more
Orthologs

Genomic context

See RACGAP1 in Genome Data Viewer
Location:
12q13.12
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (49989162..50033206, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50382945..50425586, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369764 Neighboring gene Sharpr-MPRA regulatory region 13914 Neighboring gene uncharacterized LOC102723963 Neighboring gene aquaporin 6 Neighboring gene Sharpr-MPRA regulatory region 11175 Neighboring gene acid sensing ion channel subunit 1 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Rac GTPase activating protein 1 (RACGAP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    RAC1 signaling pathway, organism-specific biosystem
    RAC1 signaling pathway
  • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of CDC42 activity, organism-specific biosystem
    Regulation of CDC42 activity
  • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RAC1 activity, organism-specific biosystem
    Regulation of RAC1 activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signal Transduction of S1P Receptor, organism-specific biosystem (from WikiPathways)
    Signal Transduction of S1P Receptor, organism-specific biosystemMetabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
gamma-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
microtubule-based movement TAS
Traceable Author Statement
more info
 
mitotic cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle midzone assembly IDA
Inferred from Direct Assay
more info
PubMed 
neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
sulfate transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Flemming body IEA
Inferred from Electronic Annotation
more info
 
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
centralspindlin complex IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rac GTPase-activating protein 1
Names
male germ cell RacGap
protein CYK4 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126103.2NP_001119575.1  rac GTPase-activating protein 1 isoform a

    See identical proteins and their annotated locations for NP_001119575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).
    Source sequence(s)
    AK315785, BC024144, BC032754, DB084617
    Consensus CDS
    CCDS8795.1
    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136, B2RE34
    Related
    ENSP00000449370.1, ENST00000547905.5
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001126104.2NP_001119576.1  rac GTPase-activating protein 1 isoform a

    See identical proteins and their annotated locations for NP_001119576.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).
    Source sequence(s)
    AK000733, BC032754, DA441098, DB084617
    Consensus CDS
    CCDS8795.1
    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Related
    ENSP00000404808.2, ENST00000454520.6
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001319999.2NP_001306928.1  rac GTPase-activating protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two exons in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).
    Source sequence(s)
    AC025154
    Consensus CDS
    CCDS8795.1
    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Related
    ENSP00000309871.5, ENST00000312377.10
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001320000.1NP_001306929.1  rac GTPase-activating protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two exons and contains an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).
    Source sequence(s)
    BC032754, DA812983, DB084617
    Consensus CDS
    CCDS8795.1
    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001320001.1NP_001306930.1  rac GTPase-activating protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two exons and uses two alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).
    Source sequence(s)
    BC032754, DA441098, DB084617, DB164810
    Consensus CDS
    CCDS8795.1
    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001320002.1NP_001306931.1  rac GTPase-activating protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two exons and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).
    Source sequence(s)
    BC032754, DA051287, DB076571, DB084617
    Consensus CDS
    CCDS8795.1
    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001320003.1NP_001306932.1  rac GTPase-activating protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two exons and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).
    Source sequence(s)
    BC032754, DA502516, DB076571, DB084617
    Consensus CDS
    CCDS8795.1
    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001320004.1NP_001306933.1  rac GTPase-activating protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks two exons and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).
    Source sequence(s)
    BC032754, DB084617
    Consensus CDS
    CCDS8795.1
    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001320005.1NP_001306934.1  rac GTPase-activating protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks three exons in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.
    Source sequence(s)
    BC032754, DB084617, DB090068
    UniProtKB/Swiss-Prot
    Q9H0H5
    Conserved Domains (2) summary
    cd00029
    Location:229277
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:288481
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  10. NM_001320006.1NP_001306935.1  rac GTPase-activating protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks two exons, contains an alternate exon, and uses an alternate splice site in the 5' region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (c) has a longer N-terminus than isoform a.
    Source sequence(s)
    BC032754, BU940828, DB076571, DB084617
    UniProtKB/Swiss-Prot
    Q9H0H5
    Conserved Domains (2) summary
    cd00029
    Location:299347
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:358551
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  11. NM_001320007.1NP_001306936.1  rac GTPase-activating protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks three exons in the 5' region and initiates translation at an alternate downstream start codon compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    BC032754, DA500396, DB084617
    UniProtKB/Swiss-Prot
    Q9H0H5
    Conserved Domains (2) summary
    cd00029
    Location:213261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:272465
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  12. NM_013277.4NP_037409.2  rac GTPase-activating protein 1 isoform a

    See identical proteins and their annotated locations for NP_037409.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the reference variant. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).
    Source sequence(s)
    AL136794, BC032754, DB076571, DB084617
    Consensus CDS
    CCDS8795.1
    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Related
    ENSP00000404190.2, ENST00000427314.6
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    49989162..50033206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448958.1XP_024304726.1  rac GTPase-activating protein 1 isoform X1

    Conserved Domains (3) summary
    cd00029
    Location:306354
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:365558
    RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...
    cl25732
    Location:32124
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_011538243.1XP_011536545.1  rac GTPase-activating protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011536545.1

    Conserved Domains (2) summary
    cd00029
    Location:213261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:272465
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  3. XM_011538238.1XP_011536540.1  rac GTPase-activating protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011536540.1

    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Related
    ENSP00000449374.1, ENST00000551016.5
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_017019227.1XP_016874716.1  rac GTPase-activating protein 1 isoform X3

    Conserved Domains (2) summary
    cd00029
    Location:213261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:272465
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  5. XM_017019224.1XP_016874713.1  rac GTPase-activating protein 1 isoform X3

    Conserved Domains (2) summary
    cd00029
    Location:213261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:272465
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  6. XM_017019222.1XP_016874711.1  rac GTPase-activating protein 1 isoform X3

    Conserved Domains (2) summary
    cd00029
    Location:213261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:272465
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  7. XM_017019221.1XP_016874710.1  rac GTPase-activating protein 1 isoform X3

    Conserved Domains (2) summary
    cd00029
    Location:213261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:272465
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  8. XM_006719359.1XP_006719422.1  rac GTPase-activating protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006719422.1

    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
  9. XM_017019223.2XP_016874712.1  rac GTPase-activating protein 1 isoform X3

    Conserved Domains (2) summary
    cd00029
    Location:213261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:272465
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  10. XM_017019225.2XP_016874714.1  rac GTPase-activating protein 1 isoform X3

    Conserved Domains (2) summary
    cd00029
    Location:213261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:272465
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  11. XM_017019226.1XP_016874715.1  rac GTPase-activating protein 1 isoform X3

    Conserved Domains (2) summary
    cd00029
    Location:213261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:272465
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
  12. XM_017019220.1XP_016874709.1  rac GTPase-activating protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9H0H5
    UniProtKB/TrEMBL
    A0A024R136
    Conserved Domains (3) summary
    cd00029
    Location:287335
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd04382
    Location:346539
    RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
    cl25732
    Location:13105
    SMC_N; RecF/RecN/SMC N terminal domain
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