Gprin1 G protein-regulated inducer of neurite outgrowth 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gprin1provided by MGI
Official Full Name: G protein-regulated inducer of neurite outgrowth 1provided by MGI
Primary source: MGI:MGI:1349455
See related: Ensembl:ENSMUSG00000069227 AllianceGenome:MGI:1349455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Z16; GRIN1
Summary: Enables phosphoprotein binding activity. Acts upstream of or within neuron projection development. Located in plasma membrane. Is expressed in several structures, including axial skeleton; bone; central nervous system; peripheral nervous system ganglion; and sensory organ. Orthologous to human GPRIN1 (G protein regulated inducer of neurite outgrowth 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 30.4), whole brain E14.5 (RPKM 27.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 29.18 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (54884484..54897486, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (54736671..54749874, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

responses to social novelty and nonspatial change remained unaffected, indicating that the Grin1(D481N) mutation induces selective deficits in sociability and spatial discrimination, while leaving intact the ability to react to novelty.
Title: Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia.
Data show that GRIN1 expression was limited to the nervous system at all developmental stages tested. GRIN1 colocalized with Galphao at neuronal dendrites and axons, but it was not detected in glial cells.
Title: Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Galphao implicate significant roles of Galphao-GRIN1 signaling in nervous system.
Binding of activated Galphao to GRIN1 induces activation of Cdc42, which leads to morphological changes in neuronal cells.
Title: Functional characterization of Galphao signaling through G protein-regulated inducer of neurite outgrowth 1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI838531 (e-PCR)
- UniSTS:164115

Sncb (e-PCR), detects polymorphism
- UniSTS:231355

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphoprotein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in growth cone	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: G protein-regulated inducer of neurite outgrowth 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316710.2 → NP_001303639.1 G protein-regulated inducer of neurite outgrowth 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC162526

Consensus CDS

CCDS26534.1

UniProtKB/Swiss-Prot

Q3UNH4, Q6PGF9, Q9QZY2

Related

ENSMUSP00000115539.2, ENSMUST00000135343.2

Conserved Domains (1) summary

pfam15235
Location:791 → 929

GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus
NM_012014.5 → NP_036144.2 G protein-regulated inducer of neurite outgrowth 1

See identical proteins and their annotated locations for NP_036144.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein

Source sequence(s)

AC162526

Consensus CDS

CCDS26534.1

UniProtKB/Swiss-Prot

Q3UNH4, Q6PGF9, Q9QZY2

Related

ENSMUSP00000097106.2, ENSMUST00000099506.2

Conserved Domains (1) summary

pfam15235
Location:791 → 929

GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus