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Zfp608 zinc finger protein 608 [ Mus musculus (house mouse) ]

Gene ID: 269023, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp608provided by MGI
Official Full Name
zinc finger protein 608provided by MGI
Primary source
MGI:MGI:2442338
See related
Ensembl:ENSMUSG00000052713 AllianceGenome:MGI:2442338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf608; 4932417D18Rik; D430007A19Rik
Summary
Predicted to enable metal ion binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in cerebral cortex; cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ZNF608 (zinc finger protein 608). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 3.8), whole brain E14.5 (RPKM 3.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp608 in Genome Data Viewer
Location:
18 D3; 18 29.28 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (55021117..55125690, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (54888045..54992591, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44634 Neighboring gene predicted gene, 33732 Neighboring gene STARR-seq mESC enhancer starr_44636 Neighboring gene STARR-positive B cell enhancer ABC_E5660 Neighboring gene predicted gene, 54030 Neighboring gene STARR-seq mESC enhancer starr_44641 Neighboring gene STARR-positive B cell enhancer ABC_E8717 Neighboring gene STARR-positive B cell enhancer ABC_E1958 Neighboring gene STARR-seq mESC enhancer starr_44642 Neighboring gene predicted gene 4221 Neighboring gene predicted gene, 41731 Neighboring gene STARR-positive B cell enhancer mm9_chr18:55210076-55210376 Neighboring gene predicted gene, 24183

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. Reed NP, et al. Genes Immun, 2013 Jan. PMID 23076336, Free PMC Article
  2. Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Ayoub AE, et al. Proc Natl Acad Sci U S A, 2011 Sep 6. PMID 21873192, Free PMC Article
  3. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zfp608 represses Rag1 and Rag2 expression indirectly by repressing the expression of Zfp609 in tymocytes.
    Title: Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116601

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of T cell differentiation in thymus TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 608

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360787.1 → NP_001347716.1  zinc finger protein 608 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC127314
    Conserved Domains (2) summary
    COG5189
    Location:85 → 166
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:676 → 894
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  2. NM_175751.4 → NP_786927.2  zinc finger protein 608 isoform 1

    See identical proteins and their annotated locations for NP_786927.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC127314, BC092219
    Consensus CDS
    CCDS37824.1
    UniProtKB/Swiss-Prot
    Q56A10, Q6ZPU8, Q8BIG5, Q8BJ06
    UniProtKB/TrEMBL
    B9EKR3
    Related
    ENSMUSP00000068192.6, ENSMUST00000064763.7
    Conserved Domains (2) summary
    COG5189
    Location:511 → 592
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:1102 → 1320
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    55021117..55125690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525957.5 → XP_006526020.1  zinc finger protein 608 isoform X1

    See identical proteins and their annotated locations for XP_006526020.1

    UniProtKB/Swiss-Prot
    Q56A10, Q6ZPU8, Q8BIG5, Q8BJ06
    UniProtKB/TrEMBL
    B9EKR3
    Conserved Domains (2) summary
    COG5189
    Location:511 → 592
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:1102 → 1320
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  2. XM_030250475.2 → XP_030106335.1  zinc finger protein 608 isoform X2

    Conserved Domains (2) summary
    COG5189
    Location:85 → 166
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:676 → 894
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  3. XM_030250473.2 → XP_030106333.1  zinc finger protein 608 isoform X1

    UniProtKB/Swiss-Prot
    Q56A10, Q6ZPU8, Q8BIG5, Q8BJ06
    UniProtKB/TrEMBL
    B9EKR3
    Conserved Domains (2) summary
    COG5189
    Location:511 → 592
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:1102 → 1320
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

RNA

  1. XR_004939857.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56A10.1 GenPept UniProtKB/Swiss-Prot:Q56A10

Gene LinkOut

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