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ZNF608 zinc finger protein 608 [ Homo sapiens (human) ]

Gene ID: 57507, updated on 26-Oct-2022

Summary

Official Symbol
ZNF608provided by HGNC
Official Full Name
zinc finger protein 608provided by HGNC
Primary source
HGNC:HGNC:29238
See related
Ensembl:ENSG00000168916 AllianceGenome:HGNC:29238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NY-REN-36
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 4.4), testis (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF608 in Genome Data Viewer
Location:
5q23.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (124636915..124748824, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (125153362..125265304, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (123972608..124084517, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1170 Neighboring gene uncharacterized LOC105379155 Neighboring gene Sharpr-MPRA regulatory region 9682 Neighboring gene uncharacterized LOC105379156 Neighboring gene ribosomal protein L28 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
EBI GWAS Catalog
Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese.
EBI GWAS Catalog
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC166851, DKFZp781C0723

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 608
Names
renal carcinoma antigen NY-REN-36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385619.1NP_001372548.1  zinc finger protein 608 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC112196, AC113398
    Consensus CDS
    CCDS34219.1
    UniProtKB/Swiss-Prot
    Q9Y5A1
    Related
    ENSP00000307746.5, ENST00000306315.9
    Conserved Domains (2) summary
    COG5189
    Location:512593
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:11031317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
  2. NM_001385620.1NP_001372549.1  zinc finger protein 608 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112196, AC113398
    Conserved Domains (2) summary
    COG5189
    Location:512593
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:11031317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
  3. NM_001385621.1NP_001372550.1  zinc finger protein 608 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC112196, AC113398
    Conserved Domains (2) summary
    COG5189
    Location:224305
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:8151029
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
  4. NM_020747.3NP_065798.2  zinc finger protein 608 isoform 1

    See identical proteins and their annotated locations for NP_065798.2

    Status: VALIDATED

    Source sequence(s)
    AC112196, AC113398
    Consensus CDS
    CCDS34219.1
    UniProtKB/Swiss-Prot
    Q9ULD9, Q9Y5A1
    UniProtKB/TrEMBL
    B3KPE6
    Related
    ENSP00000421899.2, ENST00000513986.2
    Conserved Domains (2) summary
    COG5189
    Location:512593
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:11031317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    124636915..124748824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417448.1XP_047273404.1  zinc finger protein 608 isoform X5

    Related
    ENSP00000427657.1, ENST00000504926.5
  2. XM_011543522.4XP_011541824.1  zinc finger protein 608 isoform X2

    Conserved Domains (2) summary
    COG5189
    Location:215296
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:8061020
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
  3. XM_011543523.3XP_011541825.1  zinc finger protein 608 isoform X4

    Conserved Domains (2) summary
    COG5189
    Location:127208
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:718932
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
  4. XM_011543520.4XP_011541822.1  zinc finger protein 608 isoform X1

    Conserved Domains (2) summary
    COG5189
    Location:512593
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:11031317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
  5. XM_047417447.1XP_047273403.1  zinc finger protein 608 isoform X3

  6. XM_047417446.1XP_047273402.1  zinc finger protein 608 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    125153362..125265304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)