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Sap130 Sin3A associated protein [ Mus musculus (house mouse) ]

Gene ID: 269003, updated on 6-Jun-2024

Summary

Official Symbol
Sap130provided by MGI
Official Full Name
Sin3A associated proteinprovided by MGI
Primary source
MGI:MGI:1919782
See related
Ensembl:ENSMUSG00000024260 AllianceGenome:MGI:1919782
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720406D06; 2610304F09Rik
Summary
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of Sin3-type complex. Used to study congenital heart disease and hypoplastic left heart syndrome. Orthologous to human SAP130 (Sin3A associated protein 130). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 32.4), thymus adult (RPKM 15.5) and 28 other tissues See more
Orthologs
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Genomic context

See Sap130 in Genome Data Viewer
Location:
18 B1; 18 17.81 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (31767436..31856121)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (31634368..31723068)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44147 Neighboring gene predicted gene, 38606 Neighboring gene solute carrier family 25, member 46 Neighboring gene STARR-positive B cell enhancer ABC_E10982 Neighboring gene STARR-positive B cell enhancer ABC_E7574 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:31794162-31794271 Neighboring gene STARR-positive B cell enhancer ABC_E172 Neighboring gene predicted gene, 52327 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8707 Neighboring gene AMME chromosomal region gene 1-like Neighboring gene predicted gene, 26533

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

General protein information

Preferred Names
histone deacetylase complex subunit SAP130
Names
130 kDa Sin3-associated polypeptide
Sin3A associated protein, 130kDa
sin3-associated polypeptide p130
NP_001344483.1
NP_001344484.1
NP_766553.1
XP_006526012.1
XP_006526014.1
XP_006526015.1
XP_006526016.1
XP_030106331.1
XP_036017054.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357554.2NP_001344483.1  histone deacetylase complex subunit SAP130 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156981, AC161511
    Consensus CDS
    CCDS89207.1
    UniProtKB/Swiss-Prot
    Q6NZP5, Q6P553, Q8BID9, Q8BIH0, Q9CSU1
    Related
    ENSMUSP00000157127.2, ENSMUST00000235017.2
    Conserved Domains (2) summary
    PHA03247
    Location:98492
    PHA03247; large tegument protein UL36; Provisional
    pfam16014
    Location:6351040
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
  2. NM_001357555.2NP_001344484.1  histone deacetylase complex subunit SAP130 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156981, AC161511
    Conserved Domains (4) summary
    PHA02732
    Location:257486
    PHA02732; hypothetical protein; Provisional
    pfam15254
    Location:539666
    CCDC14; Coiled-coil domain-containing protein 14
    pfam16014
    Location:6541059
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
    cl26464
    Location:8359
    Atrophin-1; Atrophin-1 family
  3. NM_172965.4NP_766553.1  histone deacetylase complex subunit SAP130 isoform 1

    See identical proteins and their annotated locations for NP_766553.1

    Status: VALIDATED

    Source sequence(s)
    AC156981, AC161511
    Consensus CDS
    CCDS57117.1
    UniProtKB/TrEMBL
    A0A0R4J060
    Related
    ENSMUSP00000025109.8, ENSMUST00000025109.8
    Conserved Domains (1) summary
    pfam16014
    Location:6341039
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    31767436..31856121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525951.4XP_006526014.1  histone deacetylase complex subunit SAP130 isoform X2

    See identical proteins and their annotated locations for XP_006526014.1

    UniProtKB/Swiss-Prot
    Q6NZP5, Q6P553, Q8BID9, Q8BIH0, Q9CSU1
    Conserved Domains (2) summary
    PHA03247
    Location:98492
    PHA03247; large tegument protein UL36; Provisional
    pfam16014
    Location:6351040
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
  2. XM_006525949.3XP_006526012.1  histone deacetylase complex subunit SAP130 isoform X1

    Conserved Domains (3) summary
    PHA02732
    Location:257486
    PHA02732; hypothetical protein; Provisional
    PHA03247
    Location:8359
    PHA03247; large tegument protein UL36; Provisional
    pfam16014
    Location:6551060
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
  3. XM_006525953.3XP_006526016.1  histone deacetylase complex subunit SAP130 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:437871
    PHA03247; large tegument protein UL36; Provisional
    pfam16014
    Location:6551025
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
  4. XM_030250471.2XP_030106331.1  histone deacetylase complex subunit SAP130 isoform X4

    Conserved Domains (4) summary
    PHA02732
    Location:257486
    PHA02732; hypothetical protein; Provisional
    PHA03247
    Location:8359
    PHA03247; large tegument protein UL36; Provisional
    PRK14971
    Location:581706
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam16014
    Location:6541024
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
  5. XM_006525952.5XP_006526015.1  histone deacetylase complex subunit SAP130 isoform X2

    See identical proteins and their annotated locations for XP_006526015.1

    UniProtKB/Swiss-Prot
    Q6NZP5, Q6P553, Q8BID9, Q8BIH0, Q9CSU1
    Conserved Domains (2) summary
    PHA03247
    Location:98492
    PHA03247; large tegument protein UL36; Provisional
    pfam16014
    Location:6351040
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
  6. XM_036161161.1XP_036017054.1  histone deacetylase complex subunit SAP130 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:34471
    PHA03247; large tegument protein UL36; Provisional
    pfam16014
    Location:6141019
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus