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Wdr24 WD repeat domain 24 [ Mus musculus (house mouse) ]

Gene ID: 268933, updated on 12-May-2024

Summary

Official Symbol
Wdr24provided by MGI
Official Full Name
WD repeat domain 24provided by MGI
Primary source
MGI:MGI:2446285
See related
Ensembl:ENSMUSG00000025737 AllianceGenome:MGI:2446285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and regulation of autophagy. Predicted to act upstream of or within autophagy. Predicted to be located in cytosol and lysosomal membrane. Predicted to be part of GATOR2 complex. Is expressed in several structures, including adrenal gland; genitourinary system; gut; lung; and spinal cord. Orthologous to human WDR24 (WD repeat domain 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 26.9), ovary adult (RPKM 24.9) and 28 other tissues See more
Orthologs
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Genomic context

See Wdr24 in Genome Data Viewer
Location:
17 A3.3; 17 12.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26042601..26047704)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25823627..25828730)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene F-box and leucine-rich repeat protein 16 Neighboring gene STARR-positive B cell enhancer ABC_E7500 Neighboring gene STARR-positive B cell enhancer ABC_E3192 Neighboring gene jumonji domain containing 8 Neighboring gene microRNA 3082 Neighboring gene STIP1 homology and U-Box containing protein 1 Neighboring gene rhomboid like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC47001

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of GATOR2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of GATOR2 complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
GATOR2 complex protein WDR24
Names
GATOR complex protein WDR24
WD repeat-containing protein 24
NP_776102.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173741.3NP_776102.1  GATOR2 complex protein WDR24

    See identical proteins and their annotated locations for NP_776102.1

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Consensus CDS
    CCDS28531.1
    UniProtKB/Swiss-Prot
    Q8CFJ9
    Related
    ENSMUSP00000026833.6, ENSMUST00000026833.6
    Conserved Domains (4) summary
    COG2319
    Location:40323
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:75118
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:86323
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl24077
    Location:742787
    Zn_ribbon_17; Zinc-ribbon, C4HC2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26042601..26047704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)