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WDR24 WD repeat domain 24 [ Homo sapiens (human) ]

Gene ID: 84219, updated on 22-Sep-2022

Summary

Official Symbol
WDR24provided by HGNC
Official Full Name
WD repeat domain 24provided by HGNC
Primary source
HGNC:HGNC:20852
See related
Ensembl:ENSG00000127580 AllianceGenome:HGNC:20852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JFP7; C16orf21
Summary
Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and regulation of autophagy. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 5.5), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See WDR24 in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (684622..690398, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (688697..694473, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (734622..740398, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene STUB1 divergent transcript Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene jumonji domain containing 8 Neighboring gene F-box and leucine rich repeat protein 16 Neighboring gene meteorin, glial cell differentiation regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • DKFZp434F054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of GATOR2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of GATOR2 complex IC
Inferred by Curator
more info
PubMed 
part_of GATOR2 complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane TAS
Traceable Author Statement
more info
 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GATOR complex protein WDR24
Names
WD repeat-containing protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032259.4NP_115635.1  GATOR complex protein WDR24

    See identical proteins and their annotated locations for NP_115635.1

    Status: VALIDATED

    Source sequence(s)
    AL136863, BC009761
    Consensus CDS
    CCDS10420.1
    UniProtKB/Swiss-Prot
    Q96S15, Q9H0B7
    Related
    ENSP00000293883.4, ENST00000293883.9
    Conserved Domains (3) summary
    sd00039
    Location:75118
    7WD40; WD40 repeat [structural motif]
    cd16693
    Location:742787
    mRING-H2-C3H3C2_WDR24; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 24 (WDR24) and similar proteins
    cl29593
    Location:86323
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    684622..690398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434767.1XP_047290723.1  GATOR complex protein WDR24 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    688697..694473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)