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WDR24 WD repeat domain 24 [ Homo sapiens (human) ]

Gene ID: 84219, updated on 7-Dec-2018

Summary

Official Symbol
WDR24provided by HGNC
Official Full Name
WD repeat domain 24provided by HGNC
Primary source
HGNC:HGNC:20852
See related
Ensembl:ENSG00000127580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JFP7; C16orf21
Expression
Ubiquitous expression in testis (RPKM 5.5), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See WDR24 in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (684622..690661, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (734622..740608, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371184 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene jumonji domain containing 8 Neighboring gene F-box and leucine rich repeat protein 16 Neighboring gene meteorin, glial cell differentiation regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Pathways from BioSystems

  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • DKFZp434F054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
GATOR2 complex IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GATOR complex protein WDR24
Names
WD repeat-containing protein 24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032259.4NP_115635.1  GATOR complex protein WDR24

    See identical proteins and their annotated locations for NP_115635.1

    Status: VALIDATED

    Source sequence(s)
    AL136863, BC009761
    Consensus CDS
    CCDS10420.1
    UniProtKB/Swiss-Prot
    Q96S15
    Related
    ENSP00000293883.4, ENST00000293883.8
    Conserved Domains (3) summary
    sd00039
    Location:75118
    7WD40; WD40 repeat [structural motif]
    cd16693
    Location:742787
    mRING-H2-C3H3C2_WDR24; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 24 (WDR24) and similar proteins
    cl25539
    Location:86323
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    684622..690661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522699.2XP_011521001.1  GATOR complex protein WDR24 isoform X1

    Related
    ENSP00000497264.1, ENST00000647644.1
    Conserved Domains (4) summary
    COG2319
    Location:40412
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:74118
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:86412
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl24077
    Location:831876
    Zn_ribbon_17; Zinc-ribbon, C4HC2 type
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