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GFER growth factor, augmenter of liver regeneration [ Homo sapiens (human) ]

Gene ID: 2671, updated on 5-Feb-2023

Summary

Official Symbol
GFERprovided by HGNC
Official Full Name
growth factor, augmenter of liver regenerationprovided by HGNC
Primary source
HGNC:HGNC:4236
See related
Ensembl:ENSG00000127554 MIM:600924; AllianceGenome:HGNC:4236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1; MMCHD; MPMCD
Summary
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 7.8), duodenum (RPKM 7.7) and 25 other tissues See more
Orthologs
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Genomic context

See GFER in Genome Data Viewer
Location:
16p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1984193..1987749)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2004138..2007694)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2034194..2037750)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 151 Neighboring gene transducin beta like 3 Neighboring gene NADPH oxidase organizer 1 Neighboring gene synaptogyrin 3 Neighboring gene zinc finger protein 598, E3 ubiquitin ligase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin-linked sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-disulfide reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to actinomycin D IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in liver development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oxidative stress-induced neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
FAD-linked sulfhydryl oxidase ALR
Names
ERV1 homolog
erv1-like growth factor
hepatic regenerative stimulation substance
hepatopoietin protein
NP_005253.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016288.1 RefSeqGene

    Range
    5045..8601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005262.3NP_005253.3  FAD-linked sulfhydryl oxidase ALR

    See identical proteins and their annotated locations for NP_005253.3

    Status: REVIEWED

    Source sequence(s)
    AF306863, BC002429, BG705583
    Consensus CDS
    CCDS32368.1
    UniProtKB/Swiss-Prot
    P55789, Q9UK40
    Related
    ENSP00000248114.6, ENST00000248114.7
    Conserved Domains (1) summary
    cl02107
    Location:86201
    Evr1_Alr; Erv1 / Alr family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1984193..1987749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791799.1 Reference GRCh38.p14 PATCHES

    Range
    50341..53897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2004138..2007694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)