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Gfer growth factor, augmenter of liver regeneration [ Mus musculus (house mouse) ]

Gene ID: 11692, updated on 29-Jan-2023

Summary

Official Symbol
Gferprovided by MGI
Official Full Name
growth factor, augmenter of liver regenerationprovided by MGI
Primary source
MGI:MGI:107757
See related
Ensembl:ENSMUSG00000040888 AllianceGenome:MGI:107757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Alr; ERV1
Summary
Predicted to enable flavin adenine dinucleotide binding activity and flavin-linked sulfhydryl oxidase activity. Predicted to be involved in several processes, including liver regeneration; negative regulation of cell death; and negative regulation of natural killer cell mediated cytotoxicity. Located in mitochondrion. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 40.9), colon adult (RPKM 27.9) and 28 other tissues See more
Orthologs
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Genomic context

See Gfer in Genome Data Viewer
Location:
17 A3.3; 17 12.48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24912163..24916133, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24693190..24696156, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 598 Neighboring gene synaptogyrin 3 Neighboring gene NADPH oxidase organizer 1 Neighboring gene transducin (beta)-like 3 Neighboring gene ring finger protein 151

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin-linked sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin-linked sulfhydryl oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables thiol oxidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
FAD-linked sulfhydryl oxidase ALR
Names
augmenter of liver regeneration
growth factor, erv1-like (augmenter of liver regeneration)
NP_001365967.1
NP_001365968.1
NP_075527.2
XP_036016164.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379038.1NP_001365967.1  FAD-linked sulfhydryl oxidase ALR isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154566, CJ043716
    UniProtKB/TrEMBL
    A0A3Q4EGL6
    Related
    ENSMUSP00000157249.2, ENSMUST00000234235.2
    Conserved Domains (1) summary
    pfam04777
    Location:87177
    Evr1_Alr; Erv1 / Alr family
  2. NM_001379039.1NP_001365968.1  FAD-linked sulfhydryl oxidase ALR isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154566
    Conserved Domains (1) summary
    cl02107
    Location:79144
    Evr1_Alr; Erv1 / Alr family
  3. NM_001409977.1NP_001396906.1  FAD-linked sulfhydryl oxidase ALR 4

    Status: VALIDATED

    Source sequence(s)
    AC154566
  4. NM_001409981.1NP_001396910.1  FAD-linked sulfhydryl oxidase ALR 5

    Status: VALIDATED

    Source sequence(s)
    AC154566
  5. NM_023040.4NP_075527.2  FAD-linked sulfhydryl oxidase ALR isoform 1

    See identical proteins and their annotated locations for NP_075527.2

    Status: VALIDATED

    Source sequence(s)
    AC154566
    Consensus CDS
    CCDS28492.1
    UniProtKB/Swiss-Prot
    P56213, Q9JJE6
    Related
    ENSMUSP00000049186.9, ENSMUST00000046839.10
    Conserved Domains (1) summary
    cl02107
    Location:79194
    Evr1_Alr; Erv1 / Alr family

RNA

  1. NR_176925.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154566
  2. NR_176926.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154566

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24912163..24916133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160271.1XP_036016164.1  FAD-linked sulfhydryl oxidase ALR isoform X1

    Conserved Domains (1) summary
    cl02107
    Location:225279
    Evr1_Alr; Erv1 / Alr family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212443.1: Suppressed sequence

    Description
    NM_212443.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.