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Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 [ Mus musculus (house mouse) ]

Gene ID: 26570, updated on 11-Mar-2023

Summary

Official Symbol
Slc7a11provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11provided by MGI
Primary source
MGI:MGI:1347355
See related
Ensembl:ENSMUSG00000027737 AllianceGenome:MGI:1347355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sut; xCT; 9930009M05Rik
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Acts upstream of or within several processes, including animal organ development; oligopeptide transmembrane transport; and regulation of cellular amino acid metabolic process. Located in apical part of cell; astrocyte projection; and brush border membrane. Is expressed in brain; meninges; and sensory organ. Used to study Hermansky-Pudlak syndrome and platelet storage pool deficiency. Orthologous to human SLC7A11 (solute carrier family 7 member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 13.5), subcutaneous fat pad adult (RPKM 12.7) and 27 other tissues See more
Orthologs
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Genomic context

See Slc7a11 in Genome Data Viewer
Location:
3 C; 3 21.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (50319385..50403947, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (50364936..50499087, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40042 Neighboring gene adhesion regulating molecule 1 pseudogene Neighboring gene predicted gene 6209 Neighboring gene predicted gene, 52657 Neighboring gene predicted gene, 38237

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
subtle gray
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-kynurenine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables cystine:glutamate antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-cystine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-cystine transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-glutamate import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-kynurenine transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dipeptide import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glutathione transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intracellular glutamate homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular glutamate homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ferroptosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within organic substance transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of AMPA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cysteine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of glutamate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of glutathione biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of melanin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neutrophil apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to organic cyclic compound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to redox state IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within striatum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ventricular system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cystine/glutamate transporter
Names
amino acid transport system xc-
cysteine/glutamate transporter
sodium independent anionic amino acid transport system
solute carrier family 7 member 11
subtle gray protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011990.2NP_036120.1  cystine/glutamate transporter

    See identical proteins and their annotated locations for NP_036120.1

    Status: VALIDATED

    Source sequence(s)
    AB022345, AC101992, BB630675
    Consensus CDS
    CCDS17335.1
    UniProtKB/Swiss-Prot
    Q9WTR6
    UniProtKB/TrEMBL
    A0A8C6H6E8, Q542C8
    Related
    ENSMUSP00000029297.5, ENSMUST00000029297.6
    Conserved Domains (2) summary
    TIGR00911
    Location:1498
    2A0308; L-type amino acid transporter
    cl00456
    Location:42291
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    50319385..50403947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500777.4XP_006500840.1  cystine/glutamate transporter isoform X2

    Conserved Domains (1) summary
    TIGR00911
    Location:78457
    2A0308; L-type amino acid transporter
  2. XM_017319590.3XP_017175079.1  cystine/glutamate transporter isoform X3

    Conserved Domains (1) summary
    TIGR00911
    Location:1322
    2A0308; L-type amino acid transporter
  3. XM_006500776.5XP_006500839.1  cystine/glutamate transporter isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:1479
    2A0308; L-type amino acid transporter