SLC7A11 solute carrier family 7 member 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC7A11provided by HGNC
Official Full Name: solute carrier family 7 member 11provided by HGNC
Primary source: HGNC:HGNC:11059
See related: Ensembl:ENSG00000151012 MIM:607933; AllianceGenome:HGNC:11059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: xCT; CCBR1
Summary: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Expression: Biased expression in brain (RPKM 12.7), thyroid (RPKM 4.9) and 8 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q28.3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (138164097..138312671, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (141487564..141565813, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (139085251..139163503, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The N6-methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma.
Title: The N6-methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma.
A Comprehensive Prognostic and Immune Analysis of Ferroptosis-Related Genes Identifies SLC7A11 as a Novel Prognostic Biomarker in Lung Adenocarcinoma.
Title: A Comprehensive Prognostic and Immune Analysis of Ferroptosis-Related Genes Identifies SLC7A11 as a Novel Prognostic Biomarker in Lung Adenocarcinoma.
xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade.
Title: xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade.
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
Title: Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
Long non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by Targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer.
Title: Long non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by Targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer.
RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner.
Title: RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m<sup>6</sup>A-dependent manner.
Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2-dependent silencing of SLC7A11.
Title: Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2-dependent silencing of SLC7A11.
The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein.
Title: The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein.
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Title: Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Inhibition of xCT suppresses the efficacy of anti-PD-1/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization.
Title: Inhibition of xCT suppresses the efficacy of anti-PD-1/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization.

Submit: New GeneRIF Correction See all GeneRIFs (111)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of solute carrier family 7, member 11 (SLC7A11) in human primary T cells	PubMed
	tat	HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-51593 (e-PCR)
- UniSTS:57862

D4S265 (e-PCR)
- UniSTS:16904

D4S3103 (e-PCR)
- UniSTS:22797

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

D15S1477 (e-PCR)
- UniSTS:474482

RH36905 (e-PCR)
- UniSTS:87932

RH121262 (e-PCR)
- UniSTS:138373

RH36112 (e-PCR)
- UniSTS:55259

Homology

Homologs of the SLC7A11 gene: The SLC7A11 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 416 organisms have orthologs with human gene SLC7A11
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cystine:glutamate antiporter activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in adult behavior	IEA Inferred from Electronic Annotation more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in dipeptide import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in glutamate homeostasis	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in lens fiber cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in limb development	IEA Inferred from Electronic Annotation more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidative stress-induced neuron death	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in regulation of AMPA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cysteine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glutamate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of neutrophil apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in response to redox state	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in striatum development	IEA Inferred from Electronic Annotation more info
involved_in ventricular system development	IEA Inferred from Electronic Annotation more info
involved_in visual learning	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in astrocyte projection	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in integral component of membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in rough endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: cystine/glutamate transporter

Names: amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014331.4 → NP_055146.1 cystine/glutamate transporter

See identical proteins and their annotated locations for NP_055146.1

Status: VALIDATED

Source sequence(s)

AC093903, AC110804, AC116610

Consensus CDS

CCDS3742.1

UniProtKB/Swiss-Prot

Q9UPY5

Related

ENSP00000280612.5, ENST00000280612.9

Conserved Domains (1) summary

TIGR00911
Location:1 → 499

2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

138164097..138312671 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047449957.1 → XP_047305913.1 cystine/glutamate transporter isoform X2
XM_047449956.1 → XP_047305912.1 cystine/glutamate transporter isoform X1
XM_011531802.4 → XP_011530104.1 cystine/glutamate transporter isoform X3

Conserved Domains (1) summary

TIGR00911
Location:1 → 483

2A0308; L-type amino acid transporter
XM_047449958.1 → XP_047305914.1 cystine/glutamate transporter isoform X4
XM_047449959.1 → XP_047305915.1 cystine/glutamate transporter isoform X5
XM_047449960.1 → XP_047305916.1 cystine/glutamate transporter isoform X6