SLC7A11 solute carrier family 7 member 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC7A11provided by HGNC
Official Full Name: solute carrier family 7 member 11provided by HGNC
Primary source: HGNC:HGNC:11059
See related: Ensembl:ENSG00000151012 MIM:607933; AllianceGenome:HGNC:11059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: xCT; CCBR1
Summary: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Expression: Biased expression in brain (RPKM 12.7), thyroid (RPKM 4.9) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q28.3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (138164097..138312671, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (141487564..141636430, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (139085251..139163503, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC7A11-associated ferroptosis in acute injury diseases: mechanisms and strategies.
Title: SLC7A11-associated ferroptosis in acute injury diseases: mechanisms and strategies.
Iron overload facilitates neonatal hypoxic-ischemic brain damage via SLC7A11-mediated ferroptosis.
Title: Iron overload facilitates neonatal hypoxic-ischemic brain damage via SLC7A11-mediated ferroptosis.
CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR-431/SLC7A11 axis.
Title: CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR-431/SLC7A11 axis.
EZH2-mediated SLC7A11 upregulation via miR-125b-5p represses ferroptosis of TSCC.
Title: EZH2-mediated SLC7A11 upregulation via miR-125b-5p represses ferroptosis of TSCC.
CIC reduces xCT/SLC7A11 expression and glutamate release in glioma.
Title: CIC reduces xCT/SLC7A11 expression and glutamate release in glioma.
Reduction of SLC7A11 and GPX4 Contributing to Ferroptosis in Sperm from Asthenozoospermia Individuals.
Title: Reduction of SLC7A11 and GPX4 Contributing to Ferroptosis in Sperm from Asthenozoospermia Individuals.
High co-expression of SLC7A11 and GPX4 as a predictor of platinum resistance and poor prognosis in patients with epithelial ovarian cancer.
Title: High co-expression of SLC7A11 and GPX4 as a predictor of platinum resistance and poor prognosis in patients with epithelial ovarian cancer.
CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis.
Title: CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis.
Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1alpha Axis.
Title: Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1α Axis.
Circular RNA hsa_circ_0018189 drives non-small cell lung cancer growth by sequestering miR-656-3p and enhancing xCT expression.
Title: Circular RNA hsa_circ_0018189 drives non-small cell lung cancer growth by sequestering miR-656-3p and enhancing xCT expression.

Submit: New GeneRIF Correction See all GeneRIFs (131)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of solute carrier family 7, member 11 (SLC7A11) in human primary T cells	PubMed
	tat	HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT)	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-51593 (e-PCR)
- UniSTS:57862

D4S265 (e-PCR)
- UniSTS:16904

D4S3103 (e-PCR)
- UniSTS:22797

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

D15S1477 (e-PCR)
- UniSTS:474482

RH36905 (e-PCR)
- UniSTS:87932

RH121262 (e-PCR)
- UniSTS:138373

RH36112 (e-PCR)
- UniSTS:55259

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables L-kynurenine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cystine:glutamate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cystine:glutamate antiporter activity	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in L-cystine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-kynurenine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in adult behavior	IEA Inferred from Electronic Annotation more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in dipeptide import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular glutamate homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lens fiber cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in limb development	IEA Inferred from Electronic Annotation more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ferroptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in regulation of AMPA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cysteine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glutamate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of neutrophil apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in response to redox state	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in striatum development	IEA Inferred from Electronic Annotation more info
involved_in ventricular system development	IEA Inferred from Electronic Annotation more info
involved_in visual learning	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in astrocyte projection	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in rough endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cystine/glutamate transporter

Names: amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014331.4 → NP_055146.1 cystine/glutamate transporter

See identical proteins and their annotated locations for NP_055146.1

Status: VALIDATED

Source sequence(s)

AC093903, AC110804, AC116610

Consensus CDS

CCDS3742.1

UniProtKB/Swiss-Prot

A8K2U4, Q9UPY5

Related

ENSP00000280612.5, ENST00000280612.9

Conserved Domains (1) summary

TIGR00911
Location:1 → 499

2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

138164097..138312671 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047449957.1 → XP_047305913.1 cystine/glutamate transporter isoform X2
XM_047449956.1 → XP_047305912.1 cystine/glutamate transporter isoform X1
XM_011531802.4 → XP_011530104.1 cystine/glutamate transporter isoform X3

Conserved Domains (1) summary

TIGR00911
Location:1 → 483

2A0308; L-type amino acid transporter
XM_047449958.1 → XP_047305914.1 cystine/glutamate transporter isoform X4
XM_047449959.1 → XP_047305915.1 cystine/glutamate transporter isoform X5
XM_047449960.1 → XP_047305916.1 cystine/glutamate transporter isoform X6