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SLC7A11 solute carrier family 7 member 11 [ Homo sapiens (human) ]

Gene ID: 23657, updated on 22-May-2022

Summary

Official Symbol
SLC7A11provided by HGNC
Official Full Name
solute carrier family 7 member 11provided by HGNC
Primary source
HGNC:HGNC:11059
See related
Ensembl:ENSG00000151012 MIM:607933; AllianceGenome:HGNC:11059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
xCT; CCBR1
Summary
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Expression
Biased expression in brain (RPKM 12.7), thyroid (RPKM 4.9) and 8 other tissues See more
Orthologs
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Genomic context

See SLC7A11 in Genome Data Viewer
Location:
4q28.3
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (138164097..138312671, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (141487564..141565813, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (139085251..139163503, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986315 Neighboring gene uncharacterized LOC105377447 Neighboring gene long intergenic non-protein coding RNA 616 Neighboring gene SLC7A11 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 499 Neighboring gene U7 small nuclear RNA Neighboring gene long intergenic non-protein coding RNA 500

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of solute carrier family 7, member 11 (SLC7A11) in human primary T cells PubMed
tat HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cystine:glutamate antiporter activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in adult behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in dipeptide import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glutathione transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in limb development IEA
Inferred from Electronic Annotation
more info
 
involved_in lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oxidative stress-induced neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of AMPA glutamate receptor clustering IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cysteine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glutamate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of melanin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neutrophil apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nicotine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in response to redox state IEA
Inferred from Electronic Annotation
more info
 
involved_in response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in striatum development IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular system development IEA
Inferred from Electronic Annotation
more info
 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 
located_in astrocyte projection IEA
Inferred from Electronic Annotation
more info
 
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cystine/glutamate transporter
Names
amino acid transport system xc-
calcium channel blocker resistance protein CCBR1
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014331.4NP_055146.1  cystine/glutamate transporter

    See identical proteins and their annotated locations for NP_055146.1

    Status: VALIDATED

    Source sequence(s)
    AC093903, AC110804, AC116610
    Consensus CDS
    CCDS3742.1
    UniProtKB/Swiss-Prot
    Q9UPY5
    Related
    ENSP00000280612.5, ENST00000280612.9
    Conserved Domains (1) summary
    TIGR00911
    Location:1499
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    138164097..138312671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449957.1XP_047305913.1  cystine/glutamate transporter isoform X2

  2. XM_047449956.1XP_047305912.1  cystine/glutamate transporter isoform X1

  3. XM_011531802.4XP_011530104.1  cystine/glutamate transporter isoform X3

    Conserved Domains (1) summary
    TIGR00911
    Location:1483
    2A0308; L-type amino acid transporter
  4. XM_047449958.1XP_047305914.1  cystine/glutamate transporter isoform X4

  5. XM_047449959.1XP_047305915.1  cystine/glutamate transporter isoform X5

  6. XM_047449960.1XP_047305916.1  cystine/glutamate transporter isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    141487564..141565813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)