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SLC7A11 solute carrier family 7 member 11 [ Homo sapiens (human) ]

Gene ID: 23657, updated on 11-Jun-2025
Official Symbol
SLC7A11provided by HGNC
Official Full Name
solute carrier family 7 member 11provided by HGNC
Primary source
HGNC:HGNC:11059
See related
Ensembl:ENSG00000151012 MIM:607933; AllianceGenome:HGNC:11059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
xCT; CCBR1
Summary
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Expression
Biased expression in brain (RPKM 12.7), thyroid (RPKM 4.9) and 8 other tissues See more
Orthologs
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See SLC7A11 in Genome Data Viewer
Location:
4q28.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (138164097..138312671, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (141487564..141636430, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (139085251..139163503, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986315 Neighboring gene uncharacterized LOC105377447 Neighboring gene long intergenic non-protein coding RNA 616 Neighboring gene SLC7A11 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:139034364-139035273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21910 Neighboring gene NANOG hESC enhancer GRCh37_chr4:139138744-139139289 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:139144028-139144638 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:139162849-139164048 Neighboring gene long intergenic non-protein coding RNA 499 Neighboring gene uncharacterized LOC124900888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21912 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:139319446-139320068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21913 Neighboring gene armadillo repeat containing 1 pseudogene

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of solute carrier family 7, member 11 (SLC7A11) in human primary T cells PubMed
tat HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT) PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-kynurenine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cystine:glutamate antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cystine:glutamate antiporter activity RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables cystine:glutamate antiporter activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-cystine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-cystine transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-kynurenine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adult behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within brain development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to stress IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dipeptide import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glutathione transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intracellular glutamate homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within limb development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ferroptosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of AMPA glutamate receptor clustering IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cysteine metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of glutamate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of melanin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of neutrophil apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of programmed cell death IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to redox state IEA
Inferred from Electronic Annotation
more info
 
involved_in response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within striatum development IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ventricular system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 
located_in astrocyte projection IEA
Inferred from Electronic Annotation
more info
 
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
cystine/glutamate transporter
Names
amino acid transport system xc-
calcium channel blocker resistance protein CCBR1
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014331.4NP_055146.1  cystine/glutamate transporter

    See identical proteins and their annotated locations for NP_055146.1

    Status: VALIDATED

    Source sequence(s)
    AC093903, AC110804, AC116610
    Consensus CDS
    CCDS3742.1
    UniProtKB/Swiss-Prot
    A8K2U4, Q9UPY5
    UniProtKB/TrEMBL
    Q9BYH2
    Related
    ENSP00000280612.5, ENST00000280612.9
    Conserved Domains (1) summary
    TIGR00911
    Location:1499
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    138164097..138312671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449957.1XP_047305913.1  cystine/glutamate transporter isoform X2

  2. XM_047449956.1XP_047305912.1  cystine/glutamate transporter isoform X1

  3. XM_011531802.4XP_011530104.1  cystine/glutamate transporter isoform X3

    UniProtKB/TrEMBL
    Q9BYH2
    Conserved Domains (1) summary
    TIGR00911
    Location:1483
    2A0308; L-type amino acid transporter
  4. XM_047449958.1XP_047305914.1  cystine/glutamate transporter isoform X4

  5. XM_047449959.1XP_047305915.1  cystine/glutamate transporter isoform X5

  6. XM_047449960.1XP_047305916.1  cystine/glutamate transporter isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    141487564..141636430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349493.1XP_054205468.1  cystine/glutamate transporter isoform X2

    UniProtKB/TrEMBL
    Q9BYH2
  2. XM_054349494.1XP_054205469.1  cystine/glutamate transporter isoform X3

    UniProtKB/TrEMBL
    Q9BYH2
  3. XM_054349492.1XP_054205467.1  cystine/glutamate transporter isoform X1

    UniProtKB/TrEMBL
    Q9BYH2
  4. XM_054349496.1XP_054205471.1  cystine/glutamate transporter isoform X7

    UniProtKB/TrEMBL
    Q9BYH2
  5. XM_054349495.1XP_054205470.1  cystine/glutamate transporter isoform X4

    UniProtKB/TrEMBL
    Q9BYH2
  6. XM_054349497.1XP_054205472.1  cystine/glutamate transporter isoform X5

  7. XM_054349498.1XP_054205473.1  cystine/glutamate transporter isoform X6