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SLC7A11 solute carrier family 7 member 11 [ Homo sapiens (human) ]

Gene ID: 23657, updated on 1-Jun-2020

Summary

Official Symbol
SLC7A11provided by HGNC
Official Full Name
solute carrier family 7 member 11provided by HGNC
Primary source
HGNC:HGNC:11059
See related
Ensembl:ENSG00000151012 MIM:607933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
xCT; CCBR1
Summary
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Expression
Biased expression in brain (RPKM 12.7), thyroid (RPKM 4.9) and 8 other tissues See more
Orthologs

Genomic context

See SLC7A11 in Genome Data Viewer
Location:
4q28.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (138164097..138242349, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (139085248..139163572, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986315 Neighboring gene uncharacterized LOC105377447 Neighboring gene long intergenic non-protein coding RNA 616 Neighboring gene SLC7A11 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 498 Neighboring gene long intergenic non-protein coding RNA 499 Neighboring gene armadillo repeat containing 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of solute carrier family 7, member 11 (SLC7A11) in human primary T cells PubMed
tat HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cystine:glutamate antiporter activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
adult behavior IEA
Inferred from Electronic Annotation
more info
 
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transport TAS
Traceable Author Statement
more info
 
cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
dipeptide import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
glutamate homeostasis IEA
Inferred from Electronic Annotation
more info
 
glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
glutathione transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
limb development IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative stress-induced neuron death IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
regulation of AMPA glutamate receptor clustering IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cysteine metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of glutamate metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of melanin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of neutrophil apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of protein transport IEA
Inferred from Electronic Annotation
more info
 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
response to redox state IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
striatum development IEA
Inferred from Electronic Annotation
more info
 
ventricular system development IEA
Inferred from Electronic Annotation
more info
 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
astrocyte projection IEA
Inferred from Electronic Annotation
more info
 
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cystine/glutamate transporter
Names
amino acid transport system xc-
calcium channel blocker resistance protein CCBR1
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014331.4NP_055146.1  cystine/glutamate transporter

    See identical proteins and their annotated locations for NP_055146.1

    Status: VALIDATED

    Source sequence(s)
    AC093903, AC110804, AC116610
    Consensus CDS
    CCDS3742.1
    UniProtKB/Swiss-Prot
    Q9UPY5
    Related
    ENSP00000280612.5, ENST00000280612.9
    Conserved Domains (1) summary
    TIGR00911
    Location:1499
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    138164097..138242349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531802.3XP_011530104.1  cystine/glutamate transporter isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:1483
    2A0308; L-type amino acid transporter

RNA

  1. XR_001741191.2 RNA Sequence

  2. XR_001741190.2 RNA Sequence

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