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Cul3 cullin 3 [ Mus musculus (house mouse) ]

Gene ID: 26554, updated on 21-Apr-2024

Summary

Official Symbol
Cul3provided by MGI
Official Full Name
cullin 3provided by MGI
Primary source
MGI:MGI:1347360
See related
Ensembl:ENSMUSG00000004364 AllianceGenome:MGI:1347360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KIAA0617
Summary
Enables cyclin binding activity and identical protein binding activity. Involved in embryonic cleavage; integrin-mediated signaling pathway; and stem cell division. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus and nucleus. Is expressed in several structures, including extraembryonic component; gonad; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.2), CNS E18 (RPKM 16.3) and 25 other tissues See more
Orthologs
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Genomic context

Location:
1 C5; 1 41.24 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (80242640..80318426, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (80264923..80340690, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310015K22 gene Neighboring gene family with sequence similarity 124, member B Neighboring gene predicted gene, 57487 Neighboring gene STARR-seq mESC enhancer starr_01455 Neighboring gene STARR-seq mESC enhancer starr_01456 Neighboring gene predicted gene, 34098 Neighboring gene STARR-positive B cell enhancer ABC_E1998 Neighboring gene STARR-seq mESC enhancer starr_01458 Neighboring gene predicted gene, 39667 Neighboring gene STARR-positive B cell enhancer ABC_E11075 Neighboring gene GLE1 RNA export mediator pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables POZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase complex scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in COPII vesicle coating ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic cleavage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear protein quality control by the ubiquitin-proteasome system ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation protein catabolic process at postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation protein catabolic process at postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation protein catabolic process at postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within trophectodermal cellular morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
part_of cullin-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in polar microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313728.2NP_001300657.1  cullin-3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC161416, AC166157
    UniProtKB/TrEMBL
    E9Q4T8
    Conserved Domains (2) summary
    smart00884
    Location:644711
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:32614
    Cullin; Cullin family
  2. NM_001421384.1NP_001408313.1  cullin-3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC161416, AC166157
  3. NM_001421385.1NP_001408314.1  cullin-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161416, AC166157
  4. NM_016716.6NP_057925.1  cullin-3 isoform 1

    See identical proteins and their annotated locations for NP_057925.1

    Status: VALIDATED

    Source sequence(s)
    AC161416, AC166157
    Consensus CDS
    CCDS15094.1
    UniProtKB/Swiss-Prot
    Q9JLV5
    UniProtKB/TrEMBL
    Q6ZQ84
    Related
    ENSMUSP00000130738.2, ENSMUST00000163119.8
    Conserved Domains (3) summary
    smart00182
    Location:421563
    CULLIN; Cullin
    pfam00888
    Location:35664
    Cullin; Cullin family
    pfam10557
    Location:700760
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    80242640..80318426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254438.2XP_030110298.1  cullin-3 isoform X1

    UniProtKB/TrEMBL
    E9Q4T8
    Conserved Domains (2) summary
    smart00884
    Location:644711
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:32614
    Cullin; Cullin family
  2. XM_030254443.2XP_030110303.1  cullin-3 isoform X2

    UniProtKB/TrEMBL
    E9Q4T8
    Conserved Domains (2) summary
    smart00884
    Location:617684
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:5587
    Cullin; Cullin family