Cul3 cullin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cul3provided by MGI
Official Full Name: cullin 3provided by MGI
Primary source: MGI:MGI:1347360
See related: Ensembl:ENSMUSG00000004364 AllianceGenome:MGI:1347360
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KIAA0617
Summary: Enables cyclin binding activity and identical protein binding activity. Involved in embryonic cleavage; integrin-mediated signaling pathway; and stem cell division. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus and nucleus. Is expressed in several structures, including extraembryonic component; gonad; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 22.2), CNS E18 (RPKM 16.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 C5

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (80242640..80318407, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (80264923..80340690, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits.
Title: Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits.
Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension.
Title: Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension.
Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney.
Title: Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney.
CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein.
Title: CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein.
Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells.
Title: Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells.
Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice.
Title: Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice.
Cul3 is required for normal development of the mammary gland.
Title: Cul3 is required for normal development of the mammary gland.
miR-23a-3p increases endometrial receptivity via CUL3 during embryo implantation.
Title: miR-23a-3p increases endometrial receptivity via CUL3 during embryo implantation.
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development.
Title: Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development.
Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3.
Title: Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI072520 (e-PCR)
- UniSTS:245001

CUL3-1 (e-PCR)
- UniSTS:510383

D9M1Mit134 (e-PCR)
- UniSTS:128469

D1Mit134 (e-PCR), detects polymorphism
- UniSTS:128469

AI467304 (e-PCR)
- UniSTS:178421

AW146203 (e-PCR)
- UniSTS:178422

Homology

Homologs of the Cul3 gene: The Cul3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, rice, and frog.
Orthologs from Annotation Pipeline: 473 organisms have orthologs with human gene Cul3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	ISO Inferred from Sequence Orthology more info	PubMed
enables POZ domain binding	ISO Inferred from Sequence Orthology more info
enables cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within anaphase-promoting complex-dependent catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in embryonic cleavage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic metaphase plate congression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in nuclear protein quality control by the ubiquitin-proteasome system	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trophectodermal cellular morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
part_of cullin-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in polar microtubule	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cullin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313728.1 → NP_001300657.1 cullin-3 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a shorter, distinct N-terminus compared to isoform 1.

Source sequence(s)

AC161416, AC166157, AF129738, AK003885, AK034695, BE991461, BM899470, CK634506

UniProtKB/Swiss-Prot

Q9JLV5

UniProtKB/TrEMBL

Q9CTE0

Conserved Domains (2) summary

smart00884
Location:644 → 711

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:32 → 614

Cullin; Cullin family
NM_016716.5 → NP_057925.1 cullin-3 isoform 1

See identical proteins and their annotated locations for NP_057925.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

AC161416, AF129738, AK003885, AK034695, BE991461, BM899470

Consensus CDS

CCDS15094.1

UniProtKB/Swiss-Prot

Q9JLV5

UniProtKB/TrEMBL

Q9CTE0

Related

ENSMUSP00000130738.2, ENSMUST00000163119.8

Conserved Domains (3) summary

smart00182
Location:421 → 563

CULLIN; Cullin

pfam00888
Location:35 → 664

Cullin; Cullin family

pfam10557
Location:700 → 760

Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

80242640..80318407 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254438.2 → XP_030110298.1 cullin-3 isoform X1

Conserved Domains (2) summary

smart00884
Location:644 → 711

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:32 → 614

Cullin; Cullin family
XM_030254443.2 → XP_030110303.1 cullin-3 isoform X2

Conserved Domains (2) summary

smart00884
Location:617 → 684

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:5 → 587

Cullin; Cullin family
XM_006496498.5 → XP_006496561.1 cullin-3 isoform X3

Related

ENSMUSP00000131891.2, ENSMUST00000164108.8

Conserved Domains (2) summary

smart00884
Location:614 → 681

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:5 → 584

Cullin; Cullin family