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Itgb1bp2 integrin beta 1 binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 26549, updated on 5-Mar-2024

Summary

Official Symbol
Itgb1bp2provided by MGI
Official Full Name
integrin beta 1 binding protein 2provided by MGI
Primary source
MGI:MGI:1353420
See related
Ensembl:ENSMUSG00000031312 AllianceGenome:MGI:1353420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chordc3
Summary
Enables calcium ion binding activity and zinc ion binding activity. Located in Z disc. Is expressed in several structures, including diaphragm; limb mesenchyme; skeletal musculature; tarsus rest of mesenchyme; and tongue. Orthologous to human ITGB1BP2 (integrin subunit beta 1 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 82.6), limb E14.5 (RPKM 19.3) and 1 other tissue See more
Orthologs
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Genomic context

Location:
X D; X 44.17 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100492694..100520391)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101449088..101466122)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene zinc finger, MYM-type 3 Neighboring gene STARR-positive B cell enhancer ABC_E7703 Neighboring gene non-POU-domain-containing, octamer binding protein Neighboring gene STARR-seq mESC enhancer starr_47650 Neighboring gene anaphase promoting complex subunit 13 pseudogene Neighboring gene ring finger protein 26 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrin beta-1-binding protein 2
Names
melusin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426134.1NP_001413063.1  integrin beta-1-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL831722
  2. NM_001426135.1NP_001413064.1  integrin beta-1-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL831722
  3. NM_013712.3NP_038740.1  integrin beta-1-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_038740.1

    Status: VALIDATED

    Source sequence(s)
    AL831722
    Consensus CDS
    CCDS41079.1
    UniProtKB/Swiss-Prot
    Q9D161, Q9R000
    Related
    ENSMUSP00000033674.6, ENSMUST00000033674.6
    Conserved Domains (2) summary
    cd06488
    Location:219305
    p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
    pfam04968
    Location:364
    CHORD; CHORD

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100492694..100520391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251354.2XP_030107214.1  integrin beta-1-binding protein 2 isoform X1

    Conserved Domains (2) summary
    pfam04968
    Location:364
    CHORD
    cl00175
    Location:219252
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  2. XM_030251355.2XP_030107215.1  integrin beta-1-binding protein 2 isoform X2

    Conserved Domains (2) summary
    pfam04968
    Location:364
    CHORD
    cl00175
    Location:219252
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RNA

  1. XR_003953009.2 RNA Sequence

  2. XR_003953011.2 RNA Sequence

  3. XR_003953010.2 RNA Sequence

  4. XR_004940338.1 RNA Sequence