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IL36RN interleukin 36 receptor antagonist [ Homo sapiens (human) ]

Gene ID: 26525, updated on 8-Dec-2018

Summary

Official Symbol
IL36RNprovided by HGNC
Official Full Name
interleukin 36 receptor antagonistprovided by HGNC
Primary source
HGNC:HGNC:15561
See related
Ensembl:ENSG00000136695 MIM:605507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 14.6), esophagus (RPKM 6.5) and 1 other tissue See more
Orthologs

Genomic context

See IL36RN in Genome Data Viewer
Location:
2q14.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (113058638..113064744)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113816215..113822321)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 36 alpha Neighboring gene interleukin 36 beta Neighboring gene interleukin 1 family member 10 Neighboring gene RNA, U6 small nuclear 1180, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29840

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antifungal humoral response IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interferon-gamma secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-36 receptor antagonist protein
Names
IL-1 related protein 3
IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta)
IL-1ra homolog 1
IL1F5 (Canonical product IL-1F5a)
interleukin 1 family, member 5 (delta)
interleukin-1 HY1
interleukin-1 receptor antagonist homolog 1
interleukin-1-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031864.1 RefSeqGene

    Range
    5001..11107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_730

mRNA and Protein(s)

  1. NM_012275.2NP_036407.1  interleukin-36 receptor antagonist protein

    See identical proteins and their annotated locations for NP_036407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC016724, AF186094
    Consensus CDS
    CCDS2111.1
    UniProtKB/Swiss-Prot
    Q9UBH0
    UniProtKB/TrEMBL
    A0A024R518
    Related
    ENSP00000376896.2, ENST00000393200.6
    Conserved Domains (1) summary
    cl00094
    Location:9152
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. NM_173170.1NP_775262.1  interleukin-36 receptor antagonist protein

    See identical proteins and their annotated locations for NP_775262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC016724, AF186094, BC024747
    Consensus CDS
    CCDS2111.1
    UniProtKB/Swiss-Prot
    Q9UBH0
    UniProtKB/TrEMBL
    A0A024R518
    Related
    ENSP00000259212.3, ENST00000346807.7
    Conserved Domains (1) summary
    cl00094
    Location:9152
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    113058638..113064744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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