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Il1f5 interleukin 1 family, member 5 (delta) [ Mus musculus (house mouse) ]

Gene ID: 54450, updated on 12-Aug-2019

Summary

Official Symbol
Il1f5provided by MGI
Official Full Name
interleukin 1 family, member 5 (delta)provided by MGI
Primary source
MGI:MGI:1859325
See related
Ensembl:ENSMUSG00000026983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL36RN; Il-1h3; Il1hy1; IL-36Ra; AI413231; Fil1delta
Expression
Biased expression in stomach adult (RPKM 9.0) and lung adult (RPKM 1.0) See more
Orthologs

Genomic context

See Il1f5 in Genome Data Viewer
Location:
2 A3; 2 16.31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24276954..24282432)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (24132474..24137952)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene interleukin 1 family, member 6 Neighboring gene interleukin 1 family, member 8 pseudogene Neighboring gene interleukin 1 family, member 10 Neighboring gene interleukin 1 receptor antagonist

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
antifungal humoral response ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interferon-gamma secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-36 receptor antagonist protein
Names
IL-1 delta
IL-1F5
IL-1HY1
IL-1L1
interleukin 1 receptor antagonist homolog 1
interleukin-1 HY1
interleukin-1 delta
interleukin-1 family member 5
interleukin-1 homolog 3
interleukin-1-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146087.1NP_001139559.1  interleukin-36 receptor antagonist protein

    See identical proteins and their annotated locations for NP_001139559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK008977, AK010020, AK014576, CJ067640
    Consensus CDS
    CCDS50519.1
    UniProtKB/Swiss-Prot
    Q9QYY1
    Related
    ENSMUSP00000028360.1, ENSMUST00000028360.7
    Conserved Domains (1) summary
    cl00094
    Location:10153
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. NM_001146088.1NP_001139560.1  interleukin-36 receptor antagonist protein

    See identical proteins and their annotated locations for NP_001139560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK008977, AK010020, AK014576, BY109350, CJ067640
    Consensus CDS
    CCDS50519.1
    UniProtKB/Swiss-Prot
    Q9QYY1
    Related
    ENSMUSP00000126028.1, ENSMUST00000168941.7
    Conserved Domains (1) summary
    cl00094
    Location:10153
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  3. NM_019451.2NP_062324.2  interleukin-36 receptor antagonist protein

    See identical proteins and their annotated locations for NP_062324.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI413231, AK009741, CJ067640
    Consensus CDS
    CCDS50519.1
    UniProtKB/Swiss-Prot
    Q9QYY1
    Related
    ENSMUSP00000110134.1, ENSMUST00000114490.6
    Conserved Domains (1) summary
    cl00094
    Location:10153
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

    Range
    24276954..24282432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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