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Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 [ Mus musculus (house mouse) ]

Gene ID: 26459, updated on 12-May-2024

Summary

Official Symbol
Slc27a5provided by MGI
Official Full Name
solute carrier family 27 (fatty acid transporter), member 5provided by MGI
Primary source
MGI:MGI:1347100
See related
Ensembl:ENSMUSG00000030382 AllianceGenome:MGI:1347100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FATP5; FACVL3; VLCSH2; Vlacsr; VLCS-H2
Summary
Enables cholate-CoA ligase activity and fatty acid transmembrane transporter activity. Acts upstream of or within several processes, including ketone body biosynthetic process; long-chain fatty acid import across plasma membrane; and triglyceride mobilization. Located in basal plasma membrane. Is expressed in liver. Orthologous to human SLC27A5 (solute carrier family 27 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 472.5) See more
Orthologs
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Genomic context

See Slc27a5 in Genome Data Viewer
Location:
7 A1; 7 7.71 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12722273..12732119, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12988346..12998192, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 324 Neighboring gene zinc finger protein 446 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13594963-13595072 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13595132-13595322 Neighboring gene STARR-positive B cell enhancer ABC_E6511 Neighboring gene CRISPRi-validated cis-regulatory element for Slc27a5, Trim28, Ube2m, Zbtb45, Zfp324 and Zfp446 Neighboring gene STARR-positive B cell enhancer ABC_E6512 Neighboring gene predicted gene, 31649 Neighboring gene tripartite motif-containing 28

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC143799

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cholate-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cholate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables long-chain fatty acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables very long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in bile acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within bile acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ketone body biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within long-chain fatty acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within triglyceride mobilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
long-chain fatty acid transport protein 5
Names
BA-CoA ligase
BACS
BAL
FATP-5
VLACS-related
bile acid-CoA ligase
bile acyl-CoA synthetase
cholate--CoA ligase
fatty acid transport protein 5
long-chain-fatty-acid--CoA ligase
solute carrier family 27 member 5
very long-chain acyl-CoA synthetase-related protein
very long-chain acyl-Coenzyme A dehydrogenase synthase related
NP_033538.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009512.2NP_033538.2  long-chain fatty acid transport protein 5

    See identical proteins and their annotated locations for NP_033538.2

    Status: VALIDATED

    Source sequence(s)
    AI173562, AK144301, BC145825
    Consensus CDS
    CCDS20821.1
    UniProtKB/Swiss-Prot
    A6H6C1, O88694, Q4LDG0, Q91VD5
    UniProtKB/TrEMBL
    Q14C57
    Related
    ENSMUSP00000032539.8, ENSMUST00000032539.14
    Conserved Domains (2) summary
    PRK08279
    Location:100685
    PRK08279; long-chain-acyl-CoA synthetase; Validated
    cl17068
    Location:139679
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12722273..12732119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)