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SLC27A5 solute carrier family 27 member 5 [ Homo sapiens (human) ]

Gene ID: 10998, updated on 13-Mar-2020

Summary

Official Symbol
SLC27A5provided by HGNC
Official Full Name
solute carrier family 27 member 5provided by HGNC
Primary source
HGNC:HGNC:10999
See related
Ensembl:ENSG00000083807 MIM:603314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAL; ACSB; BACS; FATP5; ACSVL6; FACVL3; FATP-5; VLACSR; VLCSH2; VLCS-H2
Summary
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 126.6) and testis (RPKM 2.0) See more
Orthologs

Genomic context

See SLC27A5 in Genome Data Viewer
Location:
19q13.43
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58498333..58512065, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59009700..59023432, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 446 Neighboring gene RNA, U6 small nuclear 1337, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 693, pseudogene Neighboring gene uncharacterized LOC105372485 Neighboring gene uncharacterized LOC105372486 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene RNA, 7SL, cytoplasmic 525, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22987

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cholate-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
bile acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bile acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
bile acid biosynthetic process TAS
Traceable Author Statement
more info
 
bile acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ketone body biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
plasma membrane long-chain fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride mobilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bile acyl-CoA synthetase
Names
BA-CoA ligase
VLACS-related
bile acid-CoA ligase
cholate--CoA ligase
fatty acid transport protein 5
fatty-acid-Coenzyme A ligase, very long-chain 3
solute carrier family 27 (fatty acid transporter), member 5
very long-chain acyl-CoA synthetase homolog 2
very long-chain acyl-CoA synthetase-related protein
NP_001308125.1
NP_036386.1
XP_011524666.1
XP_016881703.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047124.1 RefSeqGene

    Range
    5074..18733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321196.1NP_001308125.1  bile acyl-CoA synthetase isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AF064255, AK123036, AK298446, BU688212
    Consensus CDS
    CCDS82415.1
    UniProtKB/Swiss-Prot
    Q9Y2P5
    Related
    ENSP00000470368.1, ENST00000601355.1
    Conserved Domains (1) summary
    cl17068
    Location:146596
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. NM_012254.3NP_036386.1  bile acyl-CoA synthetase isoform 1 precursor

    See identical proteins and their annotated locations for NP_036386.1

    Status: REVIEWED

    Source sequence(s)
    AK123036, BX103174
    Consensus CDS
    CCDS12983.1
    UniProtKB/Swiss-Prot
    Q9Y2P5
    Related
    ENSP00000263093.2, ENST00000263093.7
    Conserved Domains (2) summary
    cd05938
    Location:140680
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:87690
    PRK08279; long-chain-acyl-CoA synthetase; Validated

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    58498333..58512065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526364.2XP_011524666.1  bile acyl-CoA synthetase isoform X1

    Conserved Domains (2) summary
    pfam00501
    Location:120558
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:140592
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. XM_017026214.2XP_016881703.1  bile acyl-CoA synthetase isoform X2

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