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Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 26458, updated on 8-Feb-2024

Summary

Official Symbol
Slc27a2provided by MGI
Official Full Name
solute carrier family 27 (fatty acid transporter), member 2provided by MGI
Primary source
MGI:MGI:1347099
See related
Ensembl:ENSMUSG00000027359 AllianceGenome:MGI:1347099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VLCS; Vlac; FATP2; Vlacs; ACSVL1
Summary
Enables fatty acid ligase activity; fatty acid transmembrane transporter activity; and long-chain fatty acid transporter activity. Acts upstream of or within fatty acid transport; long-chain fatty acid metabolic process; and very long-chain fatty acid catabolic process. Located in endoplasmic reticulum; peroxisome; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and sensory organ. Orthologous to human SLC27A2 (solute carrier family 27 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 780.2), liver adult (RPKM 522.9) and 3 other tissues See more
Orthologs
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Genomic context

See Slc27a2 in Genome Data Viewer
Location:
2 F1; 2 61.76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126394944..126430163)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126553024..126588243)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATPase, class I, type 8B, member 4 Neighboring gene Brca1 associated protein 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:126292531-126292684 Neighboring gene STARR-positive B cell enhancer ABC_E4495 Neighboring gene STARR-seq mESC enhancer starr_05604 Neighboring gene STARR-seq mESC enhancer starr_05605 Neighboring gene predicted gene, 26697 Neighboring gene STARR-seq mESC enhancer starr_05606 Neighboring gene STARR-positive B cell enhancer ABC_E11157 Neighboring gene histidine decarboxylase Neighboring gene GA repeat binding protein, beta 1 Neighboring gene zinc finger, BED domain containing 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables cholate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables long-chain fatty acid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables long-chain fatty acid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phytanate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables pristanate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in bile acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within carboxylic acid transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid alpha-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of long-chain fatty acid import into cell ISO
Inferred from Sequence Orthology
more info
 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in methyl-branched fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within very long-chain fatty acid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
long-chain fatty acid transport protein 2
Names
FATP-2
THCA-CoA ligase
arachidonate--CoA ligase
fatty acid transport protein 2
fatty-acid-coenzyme A ligase, very long-chain 1
long-chain-fatty-acid--CoA ligase
phytanate--CoA ligase
solute carrier family 27 member 2
very long-chain acyl-CoA synthetase
very long-chain acyl-Coenzyme A dehydrogenase synthase
very long-chain-fatty-acid-CoA ligase
NP_036108.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011978.2NP_036108.2  long-chain fatty acid transport protein 2

    See identical proteins and their annotated locations for NP_036108.2

    Status: VALIDATED

    Source sequence(s)
    AF033031, AI326155, AK165446
    Consensus CDS
    CCDS16683.1
    UniProtKB/Swiss-Prot
    O35488, O70550, O88560, Q91WV6
    UniProtKB/TrEMBL
    Q3UNR3
    Related
    ENSMUSP00000057595.8, ENSMUST00000061491.14
    Conserved Domains (1) summary
    cd05938
    Location:74610
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126394944..126430163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)