Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc27a2provided by MGI
Official Full Name: solute carrier family 27 (fatty acid transporter), member 2provided by MGI
Primary source: MGI:MGI:1347099
See related: Ensembl:ENSMUSG00000027359 AllianceGenome:MGI:1347099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VLCS; Vlac; FATP2; Vlacs; ACSVL1
Summary: Enables long-chain fatty acid transmembrane transporter activity; long-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Acts upstream of or within fatty acid transport; long-chain fatty acid metabolic process; and very long-chain fatty acid catabolic process. Located in endoplasmic reticulum; peroxisome; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and sensory organ. Orthologous to human SLC27A2 (solute carrier family 27 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 780.2), liver adult (RPKM 522.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.76 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (126394944..126430163)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (126553024..126588243)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCdelta Axis.
Title: Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis.
Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs.
Title: Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs.
Feedback loop between fatty acid transport protein 2 and receptor interacting protein 3 pathways promotes polymorphonuclear neutrophil myeloid-derived suppressor cells-potentiated suppressive immunity in bladder cancer.
Title: Feedback loop between fatty acid transport protein 2 and receptor interacting protein 3 pathways promotes polymorphonuclear neutrophil myeloid-derived suppressor cells-potentiated suppressive immunity in bladder cancer.
Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis.
Title: Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis.
Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy.
Title: Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy.
Fatty acid transport protein-2 regulates glycemic control and diabetic kidney disease progression.
Title: Fatty acid transport protein-2 regulates glycemic control and diabetic kidney disease progression.
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
Title: Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARalpha-regulated genes.
Title: Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes.
mouse and human polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) exclusively upregulate fatty acid transport protein 2 (FATP2); FATP2 mediates the acquisition of immunosuppressive activity by PMN-MDSCs and represents a target to inhibit the functions of PMN-MDSCs selectively and to improve the efficiency of cancer therapy
Title: Fatty acid transport protein 2 reprograms neutrophils in cancer.
We conclude that FATP2 is a major apical proximal tubule NEFA transporter that regulates lipoapoptosis and may be an amenable target for the prevention of CKD progression.
Title: Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid Transporter-2 (FATP2).

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AJ223958 (e-PCR)
- UniSTS:159018

Slc27a2 (e-PCR), detects polymorphism
- UniSTS:256452

Slc27a2 (e-PCR), detects polymorphism
- UniSTS:532428

Slc27a2 (e-PCR), detects polymorphism
- UniSTS:546000

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables arachidonate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables cholate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables fatty acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	TAS Traceable Author Statement more info	PubMed
enables oleate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables phytanate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables phytanate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables pristanate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables pristanate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables very long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables very long-chain fatty acid-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables very long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid alpha-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid alpha-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-chain fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in methyl-branched fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in methyl-branched fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within very long-chain fatty acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within very long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IMP Inferred from Mutant Phenotype more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: long-chain fatty acid transport protein 2

Names: FATP-2; THCA-CoA ligase; arachidonate--CoA ligase; fatty acid transport protein 2; fatty-acid-coenzyme A ligase, very long-chain 1; long-chain-fatty-acid--CoA ligase; phytanate--CoA ligase; solute carrier family 27 member 2; very long-chain acyl-CoA synthetase; very long-chain acyl-Coenzyme A dehydrogenase synthase; very long-chain-fatty-acid-CoA ligase

NP_036108.2

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

EC 6.2.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011978.2 → NP_036108.2 long-chain fatty acid transport protein 2

See identical proteins and their annotated locations for NP_036108.2

Status: VALIDATED

Source sequence(s)

AF033031, AI326155, AK165446

Consensus CDS

CCDS16683.1

UniProtKB/Swiss-Prot

O35488, O70550, O88560, Q91WV6

UniProtKB/TrEMBL

Q3UNR3

Related

ENSMUSP00000057595.8, ENSMUST00000061491.14

Conserved Domains (1) summary

cd05938
Location:74 → 610

hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins