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SLC27A2 solute carrier family 27 member 2 [ Homo sapiens (human) ]

Gene ID: 11001, updated on 10-Oct-2019

Summary

Official Symbol
SLC27A2provided by HGNC
Official Full Name
solute carrier family 27 member 2provided by HGNC
Primary source
HGNC:HGNC:10996
See related
Ensembl:ENSG00000140284 MIM:603247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VLCS; FATP2; VLACS; ACSVL1; FACVL1; hFACVL1; HsT17226
Summary
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Expression
Biased expression in liver (RPKM 63.2), kidney (RPKM 62.8) and 5 other tissues See more
Orthologs

Genomic context

See SLC27A2 in Genome Data Viewer
Location:
15q21.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (50182196..50236392)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (50474393..50528589)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8B4 (putative) Neighboring gene Sharpr-MPRA regulatory region 771 Neighboring gene ATP8B4 intron CAGE-defined high expression enhancer Neighboring gene RNA, 7SL, cytoplasmic 494, pseudogene Neighboring gene histidine decarboxylase Neighboring gene GA binding protein transcription factor subunit beta 1 Neighboring gene RNA, U6 small nuclear 94, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Alpha-oxidation of phytanate, organism-specific biosystem (from REACTOME)
    Alpha-oxidation of phytanate, organism-specific biosystemPhytanic acid arises through ruminant metabolism of chlorophyll and enters the human diet as a constituent of dairy products (Baxter 1968). It can act as an agonist for PPAR and other nuclear hormone...
  • Bile acid and bile salt metabolism, organism-specific biosystem (from REACTOME)
    Bile acid and bile salt metabolism, organism-specific biosystemIn a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily. Newly synthesized bile salts are secreted into the bile and released into the small intestine where they emulsi...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Peroxisomal lipid metabolism, organism-specific biosystem (from REACTOME)
    Peroxisomal lipid metabolism, organism-specific biosystemIn humans, the catabolism of phytanate, pristanate, and very long chain fatty acids as well as the first four steps of the biosynthesis of plasmalogens are catalyzed by peroxisomal enzymes. Defects i...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Synthesis of bile acids and bile salts, organism-specific biosystem (from REACTOME)
    Synthesis of bile acids and bile salts, organism-specific biosystemIn a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily (Russell 2003). The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol...
  • Synthesis of bile acids and bile salts via 24-hydroxycholesterol, organism-specific biosystem (from REACTOME)
    Synthesis of bile acids and bile salts via 24-hydroxycholesterol, organism-specific biosystemIn the body, 24-hydroxycholesterol is synthesized in the brain, exported to the liver, and converted there to bile acids and bile salts. This pathway is only a minor source of bile acids and bile sal...
  • Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, organism-specific biosystem (from REACTOME)
    Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, organism-specific biosystemIn the liver, synthesis of bile acids and bile salts is initiated with the conversion of cholesterol to 7alpha-hydroxycholesterol and of 7alpha-hydroxycholesterol to 4-cholesten-7alpha-ol-3-one. The ...
  • arachidonate biosynthesis III (6-desaturase, mammals), conserved biosystem (from BIOCYC)
    arachidonate biosynthesis III (6-desaturase, mammals), conserved biosystemLong-chain polyunsaturated fatty acids (PUFAs) are fatty acid that have 13 or more carbon atoms and contain more than one double bond in their backbone. The PUFAs that have 2 or more cis double bonds...
  • bile acid biosynthesis, neutral pathway, organism-specific biosystem (from BIOCYC)
    bile acid biosynthesis, neutral pathway, organism-specific biosystemGeneral Background The biosynthesis of bile acids is a major route of : CHOLESTEROL catabolism. It converts the hydrophobic, insoluble : CHOLESTEROL molecule into soluble bile acids. Accumulation ...
  • bile acid biosynthesis, neutral pathway, conserved biosystem (from BIOCYC)
    bile acid biosynthesis, neutral pathway, conserved biosystemGeneral Background The biosynthesis of bile acids is a major route of |FRAME: CHOLESTEROL| catabolism. It converts the hydrophobic, insoluble |FRAME: CHOLESTEROL| molecule into soluble bile acids. ...
  • fatty acid activation, organism-specific biosystem (from BIOCYC)
    fatty acid activation, organism-specific biosystem
    fatty acid activation
  • fatty acid alpha-oxidation, organism-specific biosystem (from BIOCYC)
    fatty acid alpha-oxidation, organism-specific biosystemGeneral Background The major pathway for fatty acid degradation in organisms ranging from bacteria to humans is fatty acid beta-oxidation. However, pathways for fatty acid alpha-oxidation and &omega...
  • fatty acid alpha-oxidation II, conserved biosystem (from BIOCYC)
    fatty acid alpha-oxidation II, conserved biosystemGeneral Background The major pathway for fatty acid degradation in organisms ranging from bacteria to humans is fatty acid beta-oxidation. However, pathways for fatty acid alpha-oxidation and &omega...
  • fatty acid beta-oxidation, organism-specific biosystem (from BIOCYC)
    fatty acid beta-oxidation, organism-specific biosystemAerobic pathway Although enzymes of the pathway handle both short and long chain fatty acids, it is the long chain compounds that induce the enzymes of the pathway. Each turn of the cycle removes t...
  • fatty acid beta-oxidation (peroxisome), organism-specific biosystem (from BIOCYC)
    fatty acid beta-oxidation (peroxisome), organism-specific biosystemGeneral Background The major site for fatty acid beta-oxidation in animal cells is the mitochondrion, although partial beta-oxidation has also been shown to occur in peroxisomes. While the same sequ...
  • fatty acid beta-oxidation I, conserved biosystem (from BIOCYC)
    fatty acid beta-oxidation I, conserved biosystemThe catabolism of fatty acids proceeds via several routes, which depend on the length of the acids, whether the number of carbons is odd or even, and whether they are saturated or unsaturated. This p...
  • fatty acid beta-oxidation VI (peroxisome), conserved biosystem (from BIOCYC)
    fatty acid beta-oxidation VI (peroxisome), conserved biosystemGeneral Background The major site for fatty acid beta-oxidation in animal cells is the mitochondrion, although partial beta-oxidation has also been shown to occur in peroxisomes. Although the same s...
  • gamma-linolenate biosynthesis, organism-specific biosystem (from BIOCYC)
    gamma-linolenate biosynthesis, organism-specific biosystemGeneral Background : CPD-8117 (GLA) is a polyunsaturated (18:3) ω-6 fatty acid (the 6 refers to the position of the first double bond from the methyl end of the fatty acid). It is synthesized ...
  • gamma-linolenate biosynthesis II (animals), conserved biosystem (from BIOCYC)
    gamma-linolenate biosynthesis II (animals), conserved biosystemGeneral Background |FRAME: CPD-8117| (GLA) is a polyunsaturated (18:3) ω-6 fatty acid (the 6 refers to the position of the first double bond from the methyl end of the fatty acid). It is synth...
  • stearate biosynthesis, organism-specific biosystem (from BIOCYC)
    stearate biosynthesis, organism-specific biosystem: STEARIC_ACID is a saturated fatty acid that occurs in many animal and vegetable fats and oils. It is an important constituent of milk fats, lard, and cocoa and shea butters. Stearate was first desc...
  • stearate biosynthesis I (animals and fungi), conserved biosystem (from BIOCYC)
    stearate biosynthesis I (animals and fungi), conserved biosystem|FRAME: STEARIC_ACID Stearate| is a saturated fatty acid that occurs in many animal and vegetable fats and oils. It is an important constituent of milk fats, lard, and cocoa and shea butters. Stearat...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
cholate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
decanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 
phytanate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phytanate-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
phytanate-CoA ligase activity TAS
Traceable Author Statement
more info
 
pristanate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pristanate-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
pristanate-CoA ligase activity TAS
Traceable Author Statement
more info
 
very long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bile acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bile acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
bile acid biosynthetic process TAS
Traceable Author Statement
more info
 
fatty acid alpha-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid alpha-oxidation TAS
Traceable Author Statement
more info
 
fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid import IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
methyl-branched fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
very long-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal membrane TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
very long-chain acyl-CoA synthetase
Names
FATP-2
THCA-CoA ligase
arachidonate--CoA ligase
fatty acid transport protein 2
fatty-acid-coenzyme A ligase, very long-chain 1
long-chain-fatty-acid--CoA ligase
phytanate--CoA ligase
solute carrier family 27 (fatty acid transporter), member 2
very long-chain fatty-acid-coenzyme A ligase 1
very long-chain-fatty-acid-CoA ligase
NP_001153101.1
NP_003636.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159629.1NP_001153101.1  very long-chain acyl-CoA synthetase isoform 2

    See identical proteins and their annotated locations for NP_001153101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is lacking an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK290262, BC057770, BM980042
    Consensus CDS
    CCDS53943.1
    UniProtKB/Swiss-Prot
    O14975
    Related
    ENSP00000370289.4, ENST00000380902.8
    Conserved Domains (2) summary
    cl17068
    Location:76557
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl27678
    Location:4798
    AMP-binding; AMP-binding enzyme
  2. NM_003645.4NP_003636.2  very long-chain acyl-CoA synthetase isoform 1

    See identical proteins and their annotated locations for NP_003636.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK223145, AK290262
    Consensus CDS
    CCDS10133.1
    UniProtKB/Swiss-Prot
    O14975
    Related
    ENSP00000267842.5, ENST00000267842.10
    Conserved Domains (2) summary
    cd05938
    Location:76610
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:30620
    PRK08279; long-chain-acyl-CoA synthetase; Validated

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    50182196..50236392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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