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Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 26457, updated on 8-Feb-2024

Summary

Official Symbol
Slc27a1provided by MGI
Official Full Name
solute carrier family 27 (fatty acid transporter), member 1provided by MGI
Primary source
MGI:MGI:1347098
See related
Ensembl:ENSMUSG00000031808 AllianceGenome:MGI:1347098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fatp; FATP1; Vlc27a1
Summary
Enables fatty acid ligase activity; fatty acid transmembrane transporter activity; and identical protein binding activity. Involved in glucose import in response to insulin stimulus; long-chain fatty acid import into cell; and positive regulation of triglyceride biosynthetic process. Acts upstream of or within several processes, including adiponectin-activated signaling pathway; lipid transport; and positive regulation of protein serine/threonine kinase activity. Located in basal plasma membrane and endoplasmic reticulum. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; phalanx; and sensory organ. Orthologous to human SLC27A1 (solute carrier family 27 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 230.7), adrenal adult (RPKM 183.8) and 18 other tissues See more
Orthologs
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Genomic context

See Slc27a1 in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72021372..72039951)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71568728..71587307)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 221 Neighboring gene STARR-positive B cell enhancer ABC_E6653 Neighboring gene nucleoredoxin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10508 Neighboring gene 6-phosphogluconolactonase Neighboring gene niban apoptosis regulator 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables biotin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables long-chain fatty acid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oleoyl-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oleoyl-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adiponectin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in biotin import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in biotin transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within carboxylic acid transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiolipin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fatty acid transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose import in response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in long-chain fatty acid import into cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid import into cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid import into cell ISO
Inferred from Sequence Orthology
more info
 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in medium-chain fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within medium-chain fatty acid transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of phospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylserine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of heat generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
long-chain fatty acid transport protein 1
Names
arachidonate--CoA ligase
fatty acid transport protein 1
long-chain-fatty-acid--CoA ligase
very long-chain acyl-CoA synthetase
NP_001344109.1
NP_001344110.1
NP_001344111.1
NP_036107.1
XP_006509734.1
XP_006509737.1
XP_006509738.1
XP_006509740.1
XP_006509741.1
XP_030099434.1
XP_030099436.1
XP_030099438.1
XP_030099439.1
XP_030099440.1
XP_030099441.1
XP_030099442.1
XP_030099443.1
XP_030099445.1
XP_030099446.1
XP_036009949.1
XP_036009950.1
XP_036009951.1
XP_036009952.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357180.1NP_001344109.1  long-chain fatty acid transport protein 1

    Status: VALIDATED

    Source sequence(s)
    AC162033, AK040923, AK137700, BY289046, BY605212
    Consensus CDS
    CCDS40386.1
    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Related
    ENSMUSP00000148768.2, ENSMUST00000212889.2
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. NM_001357181.1NP_001344110.1  long-chain fatty acid transport protein 1

    Status: VALIDATED

    Source sequence(s)
    AC162033
    Consensus CDS
    CCDS40386.1
    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. NM_001357182.1NP_001344111.1  long-chain fatty acid transport protein 1

    Status: VALIDATED

    Source sequence(s)
    AC162033
    Consensus CDS
    CCDS40386.1
    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. NM_011977.4NP_036107.1  long-chain fatty acid transport protein 1

    See identical proteins and their annotated locations for NP_036107.1

    Status: VALIDATED

    Source sequence(s)
    AC162033, AK137700, AK164798, BY289046, BY605212, CK624531
    Consensus CDS
    CCDS40386.1
    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Related
    ENSMUSP00000034267.5, ENSMUST00000034267.5
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72021372..72039951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243582.1XP_030099442.1  long-chain fatty acid transport protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. XM_006509675.4XP_006509738.1  long-chain fatty acid transport protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006509738.1

    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. XM_006509674.4XP_006509737.1  long-chain fatty acid transport protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006509737.1

    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. XM_036154057.1XP_036009950.1  long-chain fatty acid transport protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TP13
    Conserved Domains (1) summary
    cl17068
    Location:115622
    AFD_class_I; Adenylate forming domain, Class I superfamily
  5. XM_030243580.2XP_030099440.1  long-chain fatty acid transport protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  6. XM_030243579.2XP_030099439.1  long-chain fatty acid transport protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  7. XM_030243574.2XP_030099434.1  long-chain fatty acid transport protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TP13
    Conserved Domains (1) summary
    cl17068
    Location:115622
    AFD_class_I; Adenylate forming domain, Class I superfamily
  8. XM_030243578.2XP_030099438.1  long-chain fatty acid transport protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  9. XM_036154058.1XP_036009951.1  long-chain fatty acid transport protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily
  10. XM_036154056.1XP_036009949.1  long-chain fatty acid transport protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TP13
    Conserved Domains (1) summary
    cl17068
    Location:115622
    AFD_class_I; Adenylate forming domain, Class I superfamily
  11. XM_006509671.5XP_006509734.1  long-chain fatty acid transport protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TP13
    Conserved Domains (1) summary
    cl17068
    Location:115622
    AFD_class_I; Adenylate forming domain, Class I superfamily
  12. XM_030243576.2XP_030099436.1  long-chain fatty acid transport protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TP13
    Conserved Domains (1) summary
    cl17068
    Location:115622
    AFD_class_I; Adenylate forming domain, Class I superfamily
  13. XM_030243585.2XP_030099445.1  long-chain fatty acid transport protein 1 isoform X3

    Conserved Domains (1) summary
    cl17068
    Location:33427
    AFD_class_I; Adenylate forming domain, Class I superfamily
  14. XM_030243586.2XP_030099446.1  long-chain fatty acid transport protein 1 isoform X3

    Conserved Domains (1) summary
    cl17068
    Location:33427
    AFD_class_I; Adenylate forming domain, Class I superfamily
  15. XM_036154059.1XP_036009952.1  long-chain fatty acid transport protein 1 isoform X3

    Related
    ENSMUST00000212211.2
    Conserved Domains (1) summary
    cl17068
    Location:33427
    AFD_class_I; Adenylate forming domain, Class I superfamily
  16. XM_006509678.5XP_006509741.1  long-chain fatty acid transport protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006509741.1

    Conserved Domains (1) summary
    cl17068
    Location:33427
    AFD_class_I; Adenylate forming domain, Class I superfamily
  17. XM_006509677.2XP_006509740.1  long-chain fatty acid transport protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006509740.1

    Conserved Domains (1) summary
    cl17068
    Location:33427
    AFD_class_I; Adenylate forming domain, Class I superfamily
  18. XM_030243583.2XP_030099443.1  long-chain fatty acid transport protein 1 isoform X3

    Conserved Domains (1) summary
    cl17068
    Location:33427
    AFD_class_I; Adenylate forming domain, Class I superfamily
  19. XM_030243581.2XP_030099441.1  long-chain fatty acid transport protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q60714
    UniProtKB/TrEMBL
    Q3TP13, Q544D7
    Conserved Domains (1) summary
    cl17068
    Location:104611
    AFD_class_I; Adenylate forming domain, Class I superfamily

RNA

  1. XR_004934828.1 RNA Sequence

  2. XR_004934829.1 RNA Sequence

  3. XR_004934830.1 RNA Sequence

  4. XR_004934831.1 RNA Sequence

  5. XR_004934827.1 RNA Sequence