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SLC27A1 solute carrier family 27 member 1 [ Homo sapiens (human) ]

Gene ID: 376497, updated on 23-Nov-2021

Summary

Official Symbol
SLC27A1provided by HGNC
Official Full Name
solute carrier family 27 member 1provided by HGNC
Primary source
HGNC:HGNC:10995
See related
Ensembl:ENSG00000130304 MIM:600691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FATP; FATP1; ACSVL5; FATP-1
Expression
Ubiquitous expression in ovary (RPKM 10.2), fat (RPKM 9.1) and 24 other tissues See more
Orthologs
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Genomic context

See SLC27A1 in Genome Data Viewer
Location:
19p13.11
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17468745..17506169)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17581333..17616977)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 221 Neighboring gene nucleoredoxin like 1 Neighboring gene Sharpr-MPRA regulatory region 2801 Neighboring gene PGLS divergent transcript Neighboring gene Sharpr-MPRA regulatory region 7913 Neighboring gene 6-phosphogluconolactonase Neighboring gene niban apoptosis regulator 3 Neighboring gene collagen beta(1-O)galactosyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Messenger RNAs for three proteins AATK, SLC27A1, and CDKAL1 are preferentially secreted out in exosomes from HIV-1 Nef-expressing cells, and their targeting miRNAs (miR-32 and miR-93*) are retained in these cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00336, MGC71751

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables biotin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oleate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables oleoyl-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in biotin import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in biotin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiolipin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose import in response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid transport across blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-chain fatty acid import into cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid transport TAS
Traceable Author Statement
more info
 
involved_in medium-chain fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylcholine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylcholine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylethanolamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylglycerol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylserine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylserine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heat generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
colocalizes_with mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
long-chain fatty acid transport protein 1
Names
fatty acid transport protein 1
solute carrier family 27 (fatty acid transporter), member 1
NP_940982.1
XP_011526302.1
XP_011526303.1
XP_011526304.1
XP_011526305.1
XP_016882270.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198580.3NP_940982.1  long-chain fatty acid transport protein 1

    See identical proteins and their annotated locations for NP_940982.1

    Status: VALIDATED

    Source sequence(s)
    AC010618, BC059399
    Consensus CDS
    CCDS32953.1
    UniProtKB/Swiss-Prot
    Q6PCB7
    Related
    ENSP00000252595.6, ENST00000252595.12
    Conserved Domains (3) summary
    PRK08279
    Location:42644
    PRK08279; long-chain-acyl-CoA synthetase; Validated
    cl17068
    Location:101611
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl23716
    Location:64135
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17468745..17506169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528003.2XP_011526305.1  long-chain fatty acid transport protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011526305.1

    UniProtKB/Swiss-Prot
    Q6PCB7
    Conserved Domains (3) summary
    PRK08279
    Location:42644
    PRK08279; long-chain-acyl-CoA synthetase; Validated
    cl17068
    Location:101611
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl23716
    Location:64135
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  2. XM_011528000.1XP_011526302.1  long-chain fatty acid transport protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011526302.1

    Conserved Domains (3) summary
    PRK08279
    Location:42656
    PRK08279; long-chain-acyl-CoA synthetase; Validated
    cl17068
    Location:101623
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl23716
    Location:64135
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  3. XM_011528002.2XP_011526304.1  long-chain fatty acid transport protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011526304.1

    Conserved Domains (3) summary
    PRK08279
    Location:42656
    PRK08279; long-chain-acyl-CoA synthetase; Validated
    cl17068
    Location:101623
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl23716
    Location:64135
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  4. XM_017026781.1XP_016882270.1  long-chain fatty acid transport protein 1 isoform X1

    Conserved Domains (3) summary
    PRK08279
    Location:42656
    PRK08279; long-chain-acyl-CoA synthetase; Validated
    cl17068
    Location:101623
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl23716
    Location:64135
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  5. XM_011528001.2XP_011526303.1  long-chain fatty acid transport protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011526303.1

    Conserved Domains (3) summary
    PRK08279
    Location:42656
    PRK08279; long-chain-acyl-CoA synthetase; Validated
    cl17068
    Location:101623
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl23716
    Location:64135
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RNA

  1. XR_001753680.1 RNA Sequence

  2. XR_001753681.1 RNA Sequence

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