SLC27A1 solute carrier family 27 member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC27A1provided by HGNC
Official Full Name: solute carrier family 27 member 1provided by HGNC
Primary source: HGNC:HGNC:10995
See related: Ensembl:ENSG00000130304 MIM:600691; AllianceGenome:HGNC:10995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FATP; FATP1; ACSVL5; FATP-1
Summary: Enables biotin transmembrane transporter activity; efflux transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including carboxylic acid transmembrane transport; glycerophospholipid biosynthetic process; and lipid transport across blood-brain barrier. Located in membrane. Part of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary (RPKM 10.2), fat (RPKM 9.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (17468767..17506168)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (17602871..17640805)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (17581333..17616977)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of FATP1 in lipid accumulation: a review.
Title: The role of FATP1 in lipid accumulation: a review.
Unraveling FATP1, regulated by ER-beta, as a targeted breast cancer innovative therapy.
Title: Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy.
The inhibition of Fatp1 by tumor necrosis factor alpha alleviated oleate-induced total FFA and TG accumulation in macrophages.
Title: PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression.
we have established for the first time that FATP1 is a major contributor to docosahexaenoic acid efflux from human brain capillary endothelial cells
Title: Amyloid beta(25-35) impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells.
In transgenic mice, lipid droplets accumulation induced by retinal pigment cells (RPCs)-specific expression of human FATP1 was non-toxic and promoted mitochondrial energy metabolism in RPCs and non-autonomously in photoreceptor cells.
Title: Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina.
Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression
Title: Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression in two districts of southeast China.
Several proteins that are expressed in the epidermis have been proposed to facilitate the uptake of long-chain fatty acids (LCFA) in mammalian cells, CD36, fatty acid binding protein, and FATP. [review]
Title: Fatty acid transporters in skin development, function and disease.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase
Title: FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Identification of type 2 diabetes-associated combination of SNPs using support vector machine.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Messenger RNAs for three proteins AATK, SLC27A1, and CDKAL1 are preferentially secreted out in exosomes from HIV-1 Nef-expressing cells, and their targeting miRNAs (miR-32 and miR-93*) are retained in these cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S16 (e-PCR)
- UniSTS:155756

D1S1425 (e-PCR)
- UniSTS:149621

SLC27A1 (e-PCR)
- UniSTS:505723

D16S325 (e-PCR)
- UniSTS:147089

Homology

Homologs of the SLC27A1 gene: The SLC27A1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 427 organisms have orthologs with human gene SLC27A1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables arachidonate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables biotin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables fatty acid transmembrane transporter activity	TAS Traceable Author Statement more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables long-chain fatty acid transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables long-chain fatty acid-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oleate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oleoyl-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables very long-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in biotin import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in biotin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cardiolipin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose import in response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid transport across blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in long-chain fatty acid import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid import into cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid transport	TAS Traceable Author Statement more info
involved_in medium-chain fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of phospholipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in phosphatidic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylglycerol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in phosphatidylinositol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in phosphatidylserine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heat generation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to insulin	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	HDA more info	PubMed
colocalizes_with mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: long-chain fatty acid transport protein 1

Names: arachidonate--CoA ligase; fatty acid transport protein 1; long-chain-fatty-acid--CoA ligase; solute carrier family 27 (fatty acid transporter), member 1; very long-chain acyl-CoA synthetase

NP_940982.1

EC 6.2.1.15

EC 6.2.1.3

XP_011526302.1

EC 6.2.1.15

EC 6.2.1.3

XP_011526304.1

EC 6.2.1.15

EC 6.2.1.3

XP_011526305.1

EC 6.2.1.15

EC 6.2.1.3

XP_047294745.1

EC 6.2.1.15

EC 6.2.1.3

XP_047294746.1

EC 6.2.1.15

EC 6.2.1.3

XP_047294747.1

EC 6.2.1.15

EC 6.2.1.3

XP_047294748.1

EC 6.2.1.15

EC 6.2.1.3

XP_054176910.1

EC 6.2.1.15

EC 6.2.1.3

XP_054176911.1

EC 6.2.1.15

EC 6.2.1.3

XP_054176912.1

EC 6.2.1.15

EC 6.2.1.3

XP_054176913.1

EC 6.2.1.15

EC 6.2.1.3

XP_054176914.1

EC 6.2.1.15

EC 6.2.1.3

XP_054176915.1

EC 6.2.1.15

EC 6.2.1.3

XP_054176916.1

EC 6.2.1.15

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198580.3 → NP_940982.1 long-chain fatty acid transport protein 1

See identical proteins and their annotated locations for NP_940982.1

Status: VALIDATED

Source sequence(s)

AC010618, BC059399

Consensus CDS

CCDS32953.1

UniProtKB/Swiss-Prot

B7Z662, Q6PCB7

Related

ENSP00000252595.6, ENST00000252595.12

Conserved Domains (3) summary

PRK08279
Location:42 → 644

PRK08279; long-chain-acyl-CoA synthetase; Validated

cl17068
Location:101 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily

cl23716
Location:64 → 135

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

17468767..17506168

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528000.2 → XP_011526302.1 long-chain fatty acid transport protein 1 isoform X1

See identical proteins and their annotated locations for XP_011526302.1

Conserved Domains (3) summary

PRK08279
Location:42 → 656

PRK08279; long-chain-acyl-CoA synthetase; Validated

cl17068
Location:101 → 623

AFD_class_I; Adenylate forming domain, Class I superfamily

cl23716
Location:64 → 135

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
XM_011528003.3 → XP_011526305.1 long-chain fatty acid transport protein 1 isoform X2

See identical proteins and their annotated locations for XP_011526305.1

UniProtKB/Swiss-Prot

B7Z662, Q6PCB7

Conserved Domains (3) summary

PRK08279
Location:42 → 644

PRK08279; long-chain-acyl-CoA synthetase; Validated

cl17068
Location:101 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily

cl23716
Location:64 → 135

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
XM_011528002.3 → XP_011526304.1 long-chain fatty acid transport protein 1 isoform X1

See identical proteins and their annotated locations for XP_011526304.1

Conserved Domains (3) summary

PRK08279
Location:42 → 656

PRK08279; long-chain-acyl-CoA synthetase; Validated

cl17068
Location:101 → 623

AFD_class_I; Adenylate forming domain, Class I superfamily

cl23716
Location:64 → 135

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
XM_047438789.1 → XP_047294745.1 long-chain fatty acid transport protein 1 isoform X2

UniProtKB/Swiss-Prot

B7Z662
XM_047438790.1 → XP_047294746.1 long-chain fatty acid transport protein 1 isoform X2

UniProtKB/Swiss-Prot

B7Z662
XM_047438791.1 → XP_047294747.1 long-chain fatty acid transport protein 1 isoform X3
XM_047438792.1 → XP_047294748.1 long-chain fatty acid transport protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

17602871..17640805

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320939.1 → XP_054176914.1 long-chain fatty acid transport protein 1 isoform X2
XM_054320935.1 → XP_054176910.1 long-chain fatty acid transport protein 1 isoform X1
XM_054320937.1 → XP_054176912.1 long-chain fatty acid transport protein 1 isoform X2
XM_054320936.1 → XP_054176911.1 long-chain fatty acid transport protein 1 isoform X1
XM_054320938.1 → XP_054176913.1 long-chain fatty acid transport protein 1 isoform X2
XM_054320940.1 → XP_054176915.1 long-chain fatty acid transport protein 1 isoform X3
XM_054320941.1 → XP_054176916.1 long-chain fatty acid transport protein 1 isoform X4