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Psma4 proteasome subunit alpha 4 [ Mus musculus (house mouse) ]

Gene ID: 26441, updated on 8-Dec-2022

Summary

Official Symbol
Psma4provided by MGI
Official Full Name
proteasome subunit alpha 4provided by MGI
Primary source
MGI:MGI:1347060
See related
Ensembl:ENSMUSG00000032301 AllianceGenome:MGI:1347060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C9
Summary
Predicted to enable threonine-type endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Located in P-body. Part of proteasome core complex. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 71.5), CNS E11.5 (RPKM 59.3) and 27 other tissues See more
Orthologs
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Genomic context

See Psma4 in Genome Data Viewer
Location:
9; 9 B
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54858065..54865318)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54950781..54958034)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene iron responsive element binding protein 2 Neighboring gene hydroxylysine kinase 1 Neighboring gene cDNA sequence AY074887 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 5 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 3 Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proteasome subunit alpha type-4
Names
macropain subunit C9
multicatalytic endopeptidase complex subunit C9
proteasome (prosome, macropain) subunit, alpha type 4
proteasome component C9
proteasome subunit L
NP_036096.1
XP_006511261.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409691.1NP_001396620.1  proteasome subunit alpha type-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161264
    UniProtKB/Swiss-Prot
    Q3THT1
    UniProtKB/TrEMBL
    A0A6P5QJI3, A0A8C6GEK7
  2. NM_001409692.1NP_001396621.1  proteasome subunit alpha type-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161264
  3. NM_011966.4NP_036096.1  proteasome subunit alpha type-4 isoform 1

    See identical proteins and their annotated locations for NP_036096.1

    Status: VALIDATED

    Source sequence(s)
    AC161264
    Consensus CDS
    CCDS40643.1
    UniProtKB/Swiss-Prot
    Q3THT1, Q9R1P0
    UniProtKB/TrEMBL
    A0A6P5QJI3, A0A8C6GEK7
    Related
    ENSMUSP00000034848.8, ENSMUST00000034848.14
    Conserved Domains (1) summary
    cd03752
    Location:3216
    proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54858065..54865318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511198.4XP_006511261.1  proteasome subunit alpha type-4 isoform X1

    UniProtKB/Swiss-Prot
    Q9R1P0
    Related
    ENSMUSP00000126844.2, ENSMUST00000172407.8
    Conserved Domains (1) summary
    cd03752
    Location:3216
    proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...