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Psma4 proteasome subunit alpha 4 [ Mus musculus (house mouse) ]

Gene ID: 26441, updated on 5-Nov-2024

Summary

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Official Symbol
Psma4provided by MGI
Official Full Name
proteasome subunit alpha 4provided by MGI
Primary source
MGI:MGI:1347060
See related
Ensembl:ENSMUSG00000032301 AllianceGenome:MGI:1347060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C9
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body. Part of proteasome core complex. Is expressed in liver. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 71.5), CNS E11.5 (RPKM 59.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Psma4 in Genome Data Viewer
Location:
9 B; 9 29.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54858074..54865316)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54950781..54958034)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2292 Neighboring gene iron responsive element binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1787 Neighboring gene hydroxylysine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E6734 Neighboring gene cDNA sequence AY074887 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 5 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 3 Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the testis-specific proteasome subunit α4s in mammals. Uechi H, et al. J Biol Chem, 2014 May 2. PMID 24668818, Free PMC Article
  2. Intracellular distribution of oxidized proteins and proteasome in HT22 cells during oxidative stress. Jung T, et al. Free Radic Biol Med, 2006 Apr 15. PMID 16631520
  3. Proteasome subunit α4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes. Zhang ZH, et al. J Biol Chem, 2021 Jan-Jun. PMID 33262216, Free PMC Article
  4. Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice. Zhang Y, et al. Int J Biochem Cell Biol, 2023 Jun. PMID 37116777
  5. c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics. Adler J, et al. Mol Cell Biol, 2010 Aug. PMID 20498278, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
    Title: Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
  2. Proteasome subunit alpha4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes.
    Title: Proteasome subunit α4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes.
  3. Data indicate that proteasome subunit alpha4 (alpha4s) is exclusively expressed in germ cells that enter the meiotic prophase.
    Title: Characterization of the testis-specific proteasome subunit α4s in mammals.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome subunit alpha type-4
Names
alpha-3
macropain subunit C9
multicatalytic endopeptidase complex subunit C9
proteasome (prosome, macropain) subunit, alpha type 4
proteasome component C9
proteasome subunit L
proteasome subunit alpha-3
NP_001396620.1
NP_001396621.1
NP_036096.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409691.1 → NP_001396620.1  proteasome subunit alpha type-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161264
    UniProtKB/Swiss-Prot
    Q3THT1, Q9R1P0
    Related
    ENSMUSP00000126844.2, ENSMUST00000172407.8

  2. NM_001409692.1 → NP_001396621.1  proteasome subunit alpha type-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161264

  3. NM_011966.4 → NP_036096.1  proteasome subunit alpha type-4 isoform 1

    See identical proteins and their annotated locations for NP_036096.1

    Status: VALIDATED

    Source sequence(s)
    AC161264
    Consensus CDS
    CCDS40643.1
    UniProtKB/Swiss-Prot
    Q3THT1, Q9R1P0
    UniProtKB/TrEMBL
    Q3TL95
    Related
    ENSMUSP00000034848.8, ENSMUST00000034848.14
    Conserved Domains (1) summary
    cd03752
    Location:3 → 216
    proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54858074..54865316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1P0.1 GenPept UniProtKB/Swiss-Prot:Q9R1P0

Gene LinkOut

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