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GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [ Homo sapiens (human) ]

Gene ID: 26330, updated on 17-Jun-2019

Summary

Official Symbol
GAPDHSprovided by HGNC
Official Full Name
glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by HGNC
Primary source
HGNC:HGNC:24864
See related
Ensembl:ENSG00000105679 MIM:609169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAPD2; GAPDS; HSD-35; GAPDH-2; HEL-S-278
Summary
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 87.7) and thyroid (RPKM 2.9) See more
Orthologs

Genomic context

See GAPDHS in Genome Data Viewer
Location:
19q13.12
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35533456..35545319)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36024314..36036221)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene dermokine Neighboring gene suprabasin Neighboring gene TMEM147 antisense RNA 1 Neighboring gene transmembrane protein 147 Neighboring gene ATPase H+/K+ transporting subunit alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem (from REACTOME)
    Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystemTRiC has broad recognition specificities, but in the cell it interacts with only a defined set of substrates (Yam et al. 2008). Many of its substrates that are targeted during biosynthesis are conse...
  • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
    Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
  • Gluconeogenesis, organism-specific biosystem (from REACTOME)
    Gluconeogenesis, organism-specific biosystemThe reactions of gluconeogenesis convert mitochondrial pyruvate to cytosolic glucose 6-phosphate which in turn can be hydrolyzed to glucose and exported from the cell. Gluconeogenesis is confined to ...
  • Glucose metabolism, organism-specific biosystem (from REACTOME)
    Glucose metabolism, organism-specific biosystemGlucose is the major form in which dietary sugars are made available to cells of the human body. Its breakdown is a major source of energy for all cells, and is essential for the brain and red blood ...
  • Glycolysis, organism-specific biosystem (from REACTOME)
    Glycolysis, organism-specific biosystemThe reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructo...
  • Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
    Glycolysis and Gluconeogenesis, organism-specific biosystemGlycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO? + H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metab...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
  • gluconeogenesis, organism-specific biosystem (from BIOCYC)
    gluconeogenesis, organism-specific biosystem
    gluconeogenesis
  • gluconeogenesis III, conserved biosystem (from BIOCYC)
    gluconeogenesis III, conserved biosystemGeneral Background Blood glucose levels in mammals are maintained during fasting by utilization of liver glycogen stores. When this reserve is depleted, glucose must be generated from non-sugar carb...
  • glycolysis, organism-specific biosystem (from BIOCYC)
    glycolysis, organism-specific biosystemGeneral Background Glycolysis is one of the oldest metabolic pathways which occurs within the cell cytosol in nearly all organisms. The free energy released by the conversion of : Glucopyranose "glu...
  • glycolysis III (from glucose), conserved biosystem (from BIOCYC)
    glycolysis III (from glucose), conserved biosystemGeneral Background Glycolysis, which was first studied as a pathway for the utilization of glucose, is one of the major pathways of central metabolism, the other two being the |FRAME:PENTOSE-P-PWY| ...
  • homolactic fermentation, conserved biosystem (from BIOCYC)
    homolactic fermentation, conserved biosystemGeneral Background Lactic acid fermentation is a process by which sugars such as glucose, fructose, and sucrose are converted into cellular energy and the metabolic byproduct lactate. It occurs in m...
  • superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle, organism-specific biosystem (from BIOCYC)
    superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle, organism-specific biosystem
    superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
canonical glycolysis TAS
Traceable Author Statement
more info
 
flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
gluconeogenesis TAS
Traceable Author Statement
more info
 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of glycolytic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Names
epididymis secretory protein Li 278
spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2
spermatogenic glyceraldehyde-3-phosphate dehydrogenase
NP_055179.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046898.1 RefSeqGene

    Range
    5001..16908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014364.5NP_055179.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific

    See identical proteins and their annotated locations for NP_055179.1

    Status: REVIEWED

    Source sequence(s)
    AC002389, BC036373, BP370184
    Consensus CDS
    CCDS12465.1
    UniProtKB/Swiss-Prot
    O14556
    UniProtKB/TrEMBL
    A0A0K0K1K1
    Related
    ENSP00000222286.3, ENST00000222286.9
    Conserved Domains (3) summary
    COG0057
    Location:78408
    GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
    pfam00044
    Location:78224
    Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
    pfam02800
    Location:229386
    Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35533456..35545319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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