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GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [ Homo sapiens (human) ]

Gene ID: 26330, updated on 24-Nov-2020

Summary

Official Symbol
GAPDHSprovided by HGNC
Official Full Name
glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by HGNC
Primary source
HGNC:HGNC:24864
See related
Ensembl:ENSG00000105679 MIM:609169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAPD2; GAPDS; HSD-35; GAPDH-2; HEL-S-278
Summary
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 87.7) and thyroid (RPKM 2.9) See more
Orthologs

Genomic context

See GAPDHS in Genome Data Viewer
Location:
19q13.12
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35533456..35545319)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36024314..36036221)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene dermokine Neighboring gene suprabasin Neighboring gene TMEM147 antisense RNA 1 Neighboring gene transmembrane protein 147 Neighboring gene ATPase H+/K+ transporting subunit alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
canonical glycolysis TAS
Traceable Author Statement
more info
 
flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
gluconeogenesis TAS
Traceable Author Statement
more info
 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of glycolytic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Names
epididymis secretory protein Li 278
spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2
spermatogenic glyceraldehyde-3-phosphate dehydrogenase
NP_055179.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046898.1 RefSeqGene

    Range
    5045..16908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014364.5NP_055179.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific

    See identical proteins and their annotated locations for NP_055179.1

    Status: REVIEWED

    Source sequence(s)
    AC002389, BC036373, BP370184
    Consensus CDS
    CCDS12465.1
    UniProtKB/Swiss-Prot
    O14556
    UniProtKB/TrEMBL
    A0A0K0K1K1
    Related
    ENSP00000222286.3, ENST00000222286.9
    Conserved Domains (3) summary
    COG0057
    Location:78408
    GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
    pfam00044
    Location:78224
    Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
    pfam02800
    Location:229386
    Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35533456..35545319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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