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Gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [ Mus musculus (house mouse) ]

Gene ID: 14447, updated on 8-Feb-2024

Summary

Official Symbol
Gapdhsprovided by MGI
Official Full Name
glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by MGI
Primary source
MGI:MGI:95653
See related
Ensembl:ENSMUSG00000061099 AllianceGenome:MGI:95653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gapds; Gapd-s
Summary
Enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Involved in flagellated sperm motility. Acts upstream of or within glycolytic process. Located in sperm fibrous sheath and sperm principal piece. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDHS (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 682.7) See more
Orthologs
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Genomic context

See Gapdhs in Genome Data Viewer
Location:
7 B1; 7 19.23 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30429204..30443106, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30729779..30744791, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9108 Neighboring gene ATPase, H+/K+ exchanging, gastric, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E11349 Neighboring gene transmembrane protein 147 Neighboring gene suprabasin Neighboring gene dermokine Neighboring gene keratinocyte differentiation associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in flagellated sperm motility IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycolytic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
 
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Names
GAPDH-2
spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2
spermatogenic glyceraldehyde-3-phosphate dehydrogenase
NP_001277560.1
NP_032111.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290631.1NP_001277560.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC167978
    Consensus CDS
    CCDS71933.1
    UniProtKB/Swiss-Prot
    Q60650, Q64467
    UniProtKB/TrEMBL
    S4R2G5
    Related
    ENSMUSP00000138634.2, ENSMUST00000182634.8
    Conserved Domains (3) summary
    COG0057
    Location:110440
    GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
    pfam00044
    Location:110256
    Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
    pfam02800
    Location:261418
    Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
  2. NM_008085.2NP_032111.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform 2

    See identical proteins and their annotated locations for NP_032111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC167978
    Consensus CDS
    CCDS21109.1
    UniProtKB/Swiss-Prot
    Q60650, Q64467
    UniProtKB/TrEMBL
    A0A0R4J0X7
    Related
    ENSMUSP00000074317.5, ENSMUST00000074758.6
    Conserved Domains (3) summary
    COG0057
    Location:108438
    GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
    pfam00044
    Location:108254
    Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
    pfam02800
    Location:259416
    Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30429204..30443106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)