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GBP1 guanylate binding protein 1 [ Homo sapiens (human) ]

Gene ID: 2633, updated on 3-Nov-2024

Summary

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Official Symbol
GBP1provided by HGNC
Official Full Name
guanylate binding protein 1provided by HGNC
Primary source
HGNC:HGNC:4182
See related
Ensembl:ENSG00000117228 MIM:600411; AllianceGenome:HGNC:4182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hGBP1
Summary
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 60.1), lymph node (RPKM 37.4) and 24 other tissues See more
Orthologs
all
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Genomic context

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See GBP1 in Genome Data Viewer
Location:
1p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (89052319..89065208, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (88895700..88908571, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89518002..89530891, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904215 Neighboring gene guanylate binding protein 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:89487936-89489135 Neighboring gene NANOG hESC enhancer GRCh37_chr1:89496021-89496522 Neighboring gene uncharacterized LOC105378841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:89516373-89516957 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:89521826-89523025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1295 Neighboring gene Sharpr-MPRA regulatory region 5145 Neighboring gene prostaglandin E synthase 3 pseudogene 1 Neighboring gene uncharacterized LOC112268267 Neighboring gene guanylate binding protein 2 Neighboring gene Sharpr-MPRA regulatory region 4932

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. Johnston AC, et al. Cell Microbiol, 2016 Aug. PMID 26874079, Free PMC Article
  2. hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis. Xavier A, et al. Cell Rep, 2020 May 19. PMID 32433976
  3. Catalytic activity of human guanylate-binding protein 1 coupled to the release of structural restraints imposed by the C-terminal domain. Ince S, et al. FEBS J, 2021 Jan. PMID 32352209
  4. The alpha helix of the intermediate region in hGBP-1 acts as a coupler for enhanced GMP formation. Rajan S, et al. Biochim Biophys Acta Proteins Proteom, 2020 May. PMID 31954926
  5. Guanylate binding protein 1 (GBP-1) promotes cell motility and invasiveness of lung adenocarcinoma. Yamakita I, et al. Biochem Biophys Res Commun, 2019 Oct 15. PMID 31421831

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry.
    Title: Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry.
  2. GBP1 promotes cutaneous squamous cell carcinoma proliferation and invasion through activation of STAT3 by SP1.
    Title: GBP1 promotes cutaneous squamous cell carcinoma proliferation and invasion through activation of STAT3 by SP1.
  3. Interferon-gamma-induced GBP1 is an inhibitor of human papillomavirus 18.
    Title: Interferon-γ-induced GBP1 is an inhibitor of human papillomavirus 18.
  4. Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.
    Title: Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.
  5. Function and mechanism of GBP1 in the development and progression of cervical cancer.
    Title: Function and mechanism of GBP1 in the development and progression of cervical cancer.
  6. Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation.
    Title: Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation.
  7. BRCA1-associated RING domain-1 (BARD1) loss and GBP1 expression enhance sensitivity to DNA damage in Ewing sarcoma.
    Title: BRCA1-associated RING domain-1 (BARD1) loss and GBP1 expression enhance sensitivity to DNA damage in Ewing sarcoma.
  8. Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes.
    Title: Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes.
  9. Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.
    Title: Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.
  10. Guanylate Binding Protein 1 (GBP1): A Key Protein in Inflammatory Pyroptosis.
    Title: Guanylate Binding Protein 1 (GBP1): A Key Protein in Inflammatory Pyroptosis.
Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of interferon-inducible guanylate-binding protein 1 (GBP1) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytokine binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables spectrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytolysis in another organism IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to protozoan IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-canonical inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of pyroptotic inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in symbiont cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanylate-binding protein 1
Names
GBP-1
GTP-binding protein 1
guanine nucleotide-binding protein 1
guanylate binding protein 1, interferon-inducible, 67kDa
huGBP-1
interferon-induced guanylate-binding protein 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002053.3 → NP_002044.2  guanylate-binding protein 1

    See identical proteins and their annotated locations for NP_002044.2

    Status: VALIDATED

    Source sequence(s)
    AK291783, BF058809, CB164272, CD676970
    Consensus CDS
    CCDS718.1
    UniProtKB/Swiss-Prot
    D3DT26, P32455, Q5T8M1
    UniProtKB/TrEMBL
    Q5D1D5
    Related
    ENSP00000359504.4, ENST00000370473.5
    Conserved Domains (3) summary
    pfam02841
    Location:284 → 580
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18 → 282
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:290 → 580
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    89052319..89065208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    88895700..88908571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32455.2 GenPept UniProtKB/Swiss-Prot:P32455

Gene LinkOut

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