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FBXO6 F-box protein 6 [ Homo sapiens (human) ]

Gene ID: 26270, updated on 7-Oct-2018

Summary

Official Symbol
FBXO6provided by HGNC
Official Full Name
F-box protein 6provided by HGNC
Primary source
HGNC:HGNC:13585
See related
Ensembl:ENSG00000116663 MIM:605647; Vega:OTTHUMG00000002229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBG2; FBS2; FBX6; Fbx6b
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 5.5), appendix (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See FBXO6 in Genome Data Viewer
Location:
1p36.22
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (11664093..11674354)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11724150..11734411)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1647 Neighboring gene F-box protein 2 Neighboring gene F-box protein 44 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene angiotensin II receptor associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with F-box protein 6 (FBXO6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem (from REACTOME)
    Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystemTRiC has broad recognition specificities, but in the cell it interacts with only a defined set of substrates (Yam et al. 2008). Many of its substrates that are targeted during biosynthesis are conse...
  • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
    Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • SCF-FBS complex, organism-specific biosystem (from KEGG)
    SCF-FBS complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
  • SCF-FBS complex, conserved biosystem (from KEGG)
    SCF-FBS complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
DNA damage checkpoint TAS
Traceable Author Statement
more info
PubMed 
DNA repair TAS
Traceable Author Statement
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum quality control compartment IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
F-box only protein 6
Names
F-box protein FBG2
F-box protein Fbx6
F-box protein that recognizes sugar chains 2
F-box/G-domain protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018438.5NP_060908.1  F-box only protein 6

    See identical proteins and their annotated locations for NP_060908.1

    Status: REVIEWED

    Source sequence(s)
    AF129536, AK314989, BC020880
    Consensus CDS
    CCDS133.1
    UniProtKB/Swiss-Prot
    Q9NRD1
    Related
    ENSP00000365944.4, OTTHUMP00000002267, ENST00000376753.8, OTTHUMT00000006332
    Conserved Domains (2) summary
    pfam00646
    Location:1159
    F-box; F-box domain
    pfam04300
    Location:79257
    FBA; F-box associated region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    11664093..11674354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263448.5XP_005263505.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005263505.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam00646
    Location:1159
    F-box; F-box domain
    pfam04300
    Location:79257
    FBA; F-box associated region
  2. XM_017001007.2XP_016856496.1  F-box only protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam00646
    Location:1159
    F-box; F-box domain
    pfam04300
    Location:79257
    FBA; F-box associated region
  3. XM_005263451.5XP_005263508.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005263508.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam00646
    Location:1159
    F-box; F-box domain
    pfam04300
    Location:79257
    FBA; F-box associated region
  4. XM_005263449.5XP_005263506.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005263506.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Related
    ENSP00000388781.1, OTTHUMP00000002268, ENST00000449067.1
    Conserved Domains (2) summary
    pfam00646
    Location:1159
    F-box; F-box domain
    pfam04300
    Location:79257
    FBA; F-box associated region
  5. XM_011541232.3XP_011539534.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011539534.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam00646
    Location:1159
    F-box; F-box domain
    pfam04300
    Location:79257
    FBA; F-box associated region
  6. XM_006710571.3XP_006710634.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006710634.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam00646
    Location:1159
    F-box; F-box domain
    pfam04300
    Location:79257
    FBA; F-box associated region
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