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FBXO6 F-box protein 6 [ Homo sapiens (human) ]

Gene ID: 26270, updated on 8-Jul-2021

Summary

Official Symbol
FBXO6provided by HGNC
Official Full Name
F-box protein 6provided by HGNC
Primary source
HGNC:HGNC:13585
See related
Ensembl:ENSG00000116663 MIM:605647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBG2; FBS2; FBX6; Fbx6b
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 5.5), appendix (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

See FBXO6 in Genome Data Viewer
Location:
1p36.22
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (11664200..11674354)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11724257..11734411)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1647 Neighboring gene F-box protein 2 Neighboring gene F-box protein 44 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene angiotensin II receptor associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with F-box protein 6 (FBXO6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA repair TAS
Traceable Author Statement
more info
PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis TAS
Traceable Author Statement
more info
PubMed 
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum quality control compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
F-box only protein 6
Names
F-box protein FBG2
F-box protein Fbx6
F-box protein that recognizes sugar chains 2
F-box/G-domain protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018438.6NP_060908.1  F-box only protein 6

    See identical proteins and their annotated locations for NP_060908.1

    Status: REVIEWED

    Source sequence(s)
    AF129536, AK314989, BC020880
    Consensus CDS
    CCDS133.1
    UniProtKB/Swiss-Prot
    Q9NRD1
    Related
    ENSP00000365944.4, ENST00000376753.9
    Conserved Domains (2) summary
    pfam04300
    Location:79257
    FBA; F-box associated region
    pfam12937
    Location:1358
    F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    11664200..11674354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263448.5XP_005263505.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005263505.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam04300
    Location:79257
    FBA; F-box associated region
    pfam12937
    Location:1358
    F-box-like
  2. XM_017001007.2XP_016856496.1  F-box only protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam04300
    Location:79257
    FBA; F-box associated region
    pfam12937
    Location:1358
    F-box-like
  3. XM_005263451.5XP_005263508.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005263508.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam04300
    Location:79257
    FBA; F-box associated region
    pfam12937
    Location:1358
    F-box-like
  4. XM_005263449.5XP_005263506.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005263506.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Related
    ENSP00000388781.1, ENST00000449067.1
    Conserved Domains (2) summary
    pfam04300
    Location:79257
    FBA; F-box associated region
    pfam12937
    Location:1358
    F-box-like
  5. XM_011541232.3XP_011539534.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011539534.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam04300
    Location:79257
    FBA; F-box associated region
    pfam12937
    Location:1358
    F-box-like
  6. XM_006710571.3XP_006710634.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006710634.1

    UniProtKB/Swiss-Prot
    Q9NRD1
    Conserved Domains (2) summary
    pfam04300
    Location:79257
    FBA; F-box associated region
    pfam12937
    Location:1358
    F-box-like
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