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FBXO10 F-box protein 10 [ Homo sapiens (human) ]

Gene ID: 26267, updated on 12-Oct-2019

Summary

Official Symbol
FBXO10provided by HGNC
Official Full Name
F-box protein 10provided by HGNC
Primary source
HGNC:HGNC:13589
See related
Ensembl:ENSG00000147912 Ensembl:ENSG00000256966 MIM:609092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX10; PRMT11
Summary
Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 5.1), thyroid (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See FBXO10 in Genome Data Viewer
Location:
9p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (37510892..37576459, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37510889..37576250, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 3 Neighboring gene ribosomal protein L21 pseudogene 83 Neighboring gene RNA polymerase I subunit E Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene RAB1C, member RAS oncogene family pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41992, MGC149840

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
F-box only protein 10
Names
F-box protein Fbx10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012166.3NP_036298.2  F-box only protein 10

    See identical proteins and their annotated locations for NP_036298.2

    Status: VALIDATED

    Source sequence(s)
    AB209610, AF174598, AI475671, AL513165, BU623815, CN411883
    Consensus CDS
    CCDS47966.1
    UniProtKB/Swiss-Prot
    Q9UK96
    UniProtKB/TrEMBL
    Q59F51
    Related
    ENSP00000403802.2, ENST00000432825.7
    Conserved Domains (2) summary
    pfam12937
    Location:650
    F-box-like; F-box-like
    pfam13229
    Location:464610
    Beta_helix; Right handed beta helix region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    37510892..37576459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014618.1XP_016870107.1  F-box only protein 10 isoform X1

  2. XM_017014619.2XP_016870108.1  F-box only protein 10 isoform X2

    UniProtKB/Swiss-Prot
    Q9UK96
    Conserved Domains (2) summary
    pfam12937
    Location:650
    F-box-like; F-box-like
    pfam13229
    Location:464610
    Beta_helix; Right handed beta helix region
  3. XM_006716754.4XP_006716817.1  F-box only protein 10 isoform X4

    See identical proteins and their annotated locations for XP_006716817.1

    UniProtKB/Swiss-Prot
    Q9UK96
    Conserved Domains (1) summary
    pfam13229
    Location:58208
    Beta_helix; Right handed beta helix region
  4. XM_005251439.5XP_005251496.1  F-box only protein 10 isoform X3

    Related
    ENSP00000276960.7, ENST00000276960.7
    Conserved Domains (2) summary
    pfam12937
    Location:650
    F-box-like; F-box-like
    pfam13229
    Location:464610
    Beta_helix; Right handed beta helix region

RNA

  1. XR_001746270.2 RNA Sequence

  2. XR_001746271.1 RNA Sequence

    Related
    ENST00000544475.5
  3. XR_929230.2 RNA Sequence

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