FBXO10 F-box protein 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FBXO10provided by HGNC
Official Full Name: F-box protein 10provided by HGNC
Primary source: HGNC:HGNC:13589
See related: Ensembl:ENSG00000147912 Ensembl:ENSG00000256966 MIM:609092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FBX10; PRMT11
Summary: Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression: Broad expression in testis (RPKM 5.1), thyroid (RPKM 4.6) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 9p13.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109.20190905	current	GRCh38.p13 (GCF_000001405.39)	9	NC_000009.12 (37510892..37576459, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (37510889..37576250, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha expression in various cancer cells and HIF-1alpha-driven gene expressions, but the FBXO10 knockdown did not.
Title: FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.
Higher Fbxo10 expression in T cells is associated with Mcs5a increased susceptibility alleles
Title: Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).
FBXO10, a protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels.
Title: Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH120485 (e-PCR)
- UniSTS:133650

RH48090 (e-PCR)
- UniSTS:10282

WI-18403 (e-PCR)
- UniSTS:58162

Cda0wc05 (e-PCR)
- UniSTS:59444

A004G26 (e-PCR)
- UniSTS:11335

A008K33 (e-PCR)
- UniSTS:14668

RH45392 (e-PCR)
- UniSTS:14675

D9S1718 (e-PCR)
- UniSTS:44930

Homology

Homologs of the FBXO10 gene: The FBXO10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 257 organisms have orthologs with human gene FBXO10
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ubiquitin-protein transferase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
post-translational protein modification	TAS Traceable Author Statement more info
protein polyubiquitination	TAS Traceable Author Statement more info
protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein ubiquitination	NAS Non-traceable Author Statement more info	PubMed
regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
ubiquitin ligase complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: F-box only protein 10

Names: F-box protein Fbx10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012166.3 → NP_036298.2 F-box only protein 10

See identical proteins and their annotated locations for NP_036298.2

Status: VALIDATED

Source sequence(s)

AB209610, AF174598, AI475671, AL513165, BU623815, CN411883

Consensus CDS

CCDS47966.1

UniProtKB/Swiss-Prot

Q9UK96

UniProtKB/TrEMBL

Q59F51

Related

ENSP00000403802.2, ENST00000432825.7

Conserved Domains (2) summary

pfam12937
Location:6 → 50

F-box-like; F-box-like

pfam13229
Location:464 → 610

Beta_helix; Right handed beta helix region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p13 Primary Assembly

Range

37510892..37576459 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017014618.1 → XP_016870107.1 F-box only protein 10 isoform X1
XM_017014619.2 → XP_016870108.1 F-box only protein 10 isoform X2

UniProtKB/Swiss-Prot

Q9UK96

Conserved Domains (2) summary

pfam12937
Location:6 → 50

F-box-like; F-box-like

pfam13229
Location:464 → 610

Beta_helix; Right handed beta helix region
XM_006716754.4 → XP_006716817.1 F-box only protein 10 isoform X4

See identical proteins and their annotated locations for XP_006716817.1

UniProtKB/Swiss-Prot

Q9UK96

Conserved Domains (1) summary

pfam13229
Location:58 → 208

Beta_helix; Right handed beta helix region
XM_005251439.5 → XP_005251496.1 F-box only protein 10 isoform X3

Related

ENSP00000276960.7, ENST00000276960.7

Conserved Domains (2) summary

pfam12937
Location:6 → 50

F-box-like; F-box-like

pfam13229
Location:464 → 610

Beta_helix; Right handed beta helix region