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FBXO22 F-box protein 22 [ Homo sapiens (human) ]

Gene ID: 26263, updated on 5-Aug-2018

Summary

Official Symbol
FBXO22provided by HGNC
Official Full Name
F-box protein 22provided by HGNC
Primary source
HGNC:HGNC:13593
See related
Ensembl:ENSG00000167196 MIM:609096; Vega:OTTHUMG00000142841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX22; FISTC1
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in prostate (RPKM 5.0), kidney (RPKM 4.8) and 25 other tissues See more
Orthologs

Genomic context

See FBXO22 in Genome Data Viewer
Location:
15q24.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (75903859..75935268)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76196200..76227609)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dynamin 1 pseudogene 49 Neighboring gene ubiquitin conjugating enzyme E2 Q2 Neighboring gene RNA, 7SL, cytoplasmic 510, pseudogene Neighboring gene neuregulin 4 Neighboring gene transmembrane protein 266 Neighboring gene uncharacterized LOC101929439 Neighboring gene electron transfer flavoprotein subunit alpha Neighboring gene TYRO3P protein tyrosine kinase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13986, MGC31799

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
regulation of skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Z disc IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
F-box only protein 22
Names
F-box protein FBX22p44
FIST domain containing 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012170.3NP_036302.1  F-box only protein 22 isoform b

    See identical proteins and their annotated locations for NP_036302.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 3' coding sequence and 3' UTR compared to variant 1. This results in a shorter isoform (b) with a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC027104, AK024048, AL705285, BC020204
    Consensus CDS
    CCDS45310.1
    UniProtKB/Swiss-Prot
    Q8NEZ5
    Related
    ENSP00000396442.2, OTTHUMP00000249412, ENST00000453211.6, OTTHUMT00000420645
    Conserved Domains (1) summary
    pfam12937
    Location:2858
    F-box-like; F-box-like
  2. NM_147188.2NP_671717.1  F-box only protein 22 isoform a

    See identical proteins and their annotated locations for NP_671717.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC027104, AW292124, BC020204
    Consensus CDS
    CCDS10287.1
    UniProtKB/Swiss-Prot
    Q8NEZ5
    Related
    ENSP00000307833.3, OTTHUMP00000183525, ENST00000308275.7, OTTHUMT00000286477
    Conserved Domains (2) summary
    pfam10442
    Location:301364
    FIST_C; FIST C domain
    pfam12937
    Location:2858
    F-box-like; F-box-like

RNA

  1. NR_037623.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027104, AW292124, BC020204, BC039024

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    75903859..75935268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521447.3XP_011519749.1  F-box only protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011519749.1

    UniProtKB/Swiss-Prot
    Q8NEZ5
    Conserved Domains (1) summary
    pfam10442
    Location:197260
    FIST_C; FIST C domain
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