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Fbxo22 F-box protein 22 [ Mus musculus (house mouse) ]

Gene ID: 71999, updated on 12-May-2024

Summary

Official Symbol
Fbxo22provided by MGI
Official Full Name
F-box protein 22provided by MGI
Primary source
MGI:MGI:1926014
See related
Ensembl:ENSMUSG00000032309 AllianceGenome:MGI:1926014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610033L19Rik; 1600016C16Rik
Summary
Acts upstream of or within several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of skeletal muscle fiber development. Located in cytoplasm and nucleus. Orthologous to human FBXO22 (F-box protein 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 12.5), CNS E11.5 (RPKM 7.6) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxo22 in Genome Data Viewer
Location:
9 B; 9 29.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55116219..55131717)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55208935..55224433)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24182 Neighboring gene STARR-seq mESC enhancer starr_24183 Neighboring gene STARR-seq mESC enhancer starr_24184 Neighboring gene STARR-seq mESC enhancer starr_24185 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene ubiquitin-conjugating enzyme E2Q family member 2 Neighboring gene STARR-seq mESC enhancer starr_24186 Neighboring gene neuregulin 4 Neighboring gene STARR-positive B cell enhancer ABC_E9762 Neighboring gene serpine1 mRNA binding protein 1 pseudogene Neighboring gene transmembrane protein 266

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of skeletal muscle fiber development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028049.2NP_082325.2  F-box only protein 22

    See identical proteins and their annotated locations for NP_082325.2

    Status: VALIDATED

    Source sequence(s)
    AK005473, AW490772, CJ078336
    Consensus CDS
    CCDS23202.2
    UniProtKB/Swiss-Prot
    Q78JE5
    Related
    ENSMUSP00000034859.9, ENSMUST00000034859.15
    Conserved Domains (2) summary
    pfam10442
    Location:265363
    FIST_C; FIST C domain
    pfam12937
    Location:2757
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    55116219..55131717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511459.4XP_006511522.1  F-box only protein 22 isoform X1

    See identical proteins and their annotated locations for XP_006511522.1

    UniProtKB/TrEMBL
    Q3V492
    Related
    ENSMUSP00000117106.2, ENSMUST00000146201.8
    Conserved Domains (1) summary
    COG4398
    Location:195294
    FIST; Small ligand-binding sensory domain FIST [Signal transduction mechanisms]