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ARL5A ADP ribosylation factor like GTPase 5A [ Homo sapiens (human) ]

Gene ID: 26225, updated on 11-Jun-2021

Summary

Official Symbol
ARL5Aprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 5Aprovided by HGNC
Primary source
HGNC:HGNC:696
See related
Ensembl:ENSG00000162980 MIM:608960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL5; ARFLP5
Summary
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 27.2), heart (RPKM 19.5) and 25 other tissues See more
Orthologs
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Genomic context

See ARL5A in Genome Data Viewer
Location:
2q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (151798797..151828421, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (152655311..152684935, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NEB-ARL5A intergenic CAGE-defined B cell enhancer Neighboring gene uncharacterized LOC101929356 Neighboring gene Sharpr-MPRA regulatory region 4301 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 4 Neighboring gene signal transducing adaptor molecule 2 Neighboring gene ribosomal protein L30 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies ARL5A, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to Golgi membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 5A
Names
ADP-ribosylation factor-like 5
ADP-ribosylation factor-like 5A
ADP-ribosylation factor-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037174.2NP_001032251.1  ADP-ribosylation factor-like protein 5A isoform 2

    See identical proteins and their annotated locations for NP_001032251.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks alternate segments in the 5' UTR and coding region compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC097448
    Consensus CDS
    CCDS46425.1
    UniProtKB/Swiss-Prot
    Q9Y689
    Conserved Domains (1) summary
    cl38936
    Location:1138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_012097.4NP_036229.1  ADP-ribosylation factor-like protein 5A isoform 1

    See identical proteins and their annotated locations for NP_036229.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC097448
    Consensus CDS
    CCDS2195.1
    UniProtKB/Swiss-Prot
    Q9Y689
    Related
    ENSP00000295087.8, ENST00000295087.13
    Conserved Domains (1) summary
    cd04153
    Location:3175
    Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases
  3. NM_177985.3NP_817114.2  ADP-ribosylation factor-like protein 5A isoform 2

    See identical proteins and their annotated locations for NP_817114.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR and coding region compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC097448, BX461356, CX867116
    Consensus CDS
    CCDS46425.1
    UniProtKB/Swiss-Prot
    Q9Y689
    Related
    ENSP00000415950.1, ENST00000428992.2
    Conserved Domains (1) summary
    cl38936
    Location:1138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    151798797..151828421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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