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GAS2 growth arrest specific 2 [ Homo sapiens (human) ]

Gene ID: 2620, updated on 3-Oct-2021

Summary

Official Symbol
GAS2provided by HGNC
Official Full Name
growth arrest specific 2provided by HGNC
Primary source
HGNC:HGNC:4167
See related
Ensembl:ENSG00000148935 MIM:602835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAS-2
Summary
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]
Expression
Broad expression in liver (RPKM 2.8), kidney (RPKM 0.9) and 21 other tissues See more
Orthologs
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Genomic context

See GAS2 in Genome Data Viewer
Location:
11p14.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (22627758..22885930)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (22688157..22834601)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376588 Neighboring gene FA complementation group F Neighboring gene RNA, 5S ribosomal pseudogene 338 Neighboring gene Sharpr-MPRA regulatory region 14851 Neighboring gene small VCP interacting protein Neighboring gene coiled-coil domain containing 179 Neighboring gene uncharacterized LOC105376591 Neighboring gene long intergenic non-protein coding RNA 2718

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC32610

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antral ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in basement membrane organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in initiation of primordial ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
involved_in ovulation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
growth arrest-specific protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143830.3NP_001137302.1  growth arrest-specific protein 2 isoform a

    See identical proteins and their annotated locations for NP_001137302.1

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801
    Consensus CDS
    CCDS7858.1
    UniProtKB/Swiss-Prot
    O43903
    Related
    ENSP00000401145.2, ENST00000454584.6
    Conserved Domains (2) summary
    smart00243
    Location:200273
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2
  2. NM_001351224.3NP_001338153.1  growth arrest-specific protein 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801
    Conserved Domains (2) summary
    cd00014
    Location:35157
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl02524
    Location:200243
    GAS2; Growth-Arrest-Specific Protein 2 Domain
  3. NM_001391933.1NP_001378862.1  growth arrest-specific protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801
    Conserved Domains (2) summary
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2
    cl02524
    Location:200291
    GAS2; Growth-Arrest-Specific Protein 2 Domain
  4. NM_001391934.1NP_001378863.1  growth arrest-specific protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801
    Conserved Domains (2) summary
    smart00243
    Location:200273
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2
  5. NM_001391935.1NP_001378864.1  growth arrest-specific protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801
    Conserved Domains (2) summary
    smart00243
    Location:200273
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2
  6. NM_001391936.1NP_001378865.1  growth arrest-specific protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801
    Conserved Domains (2) summary
    smart00243
    Location:200273
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2
  7. NM_001391937.1NP_001378866.1  growth arrest-specific protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801
    Conserved Domains (2) summary
    smart00243
    Location:200273
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2
  8. NM_005256.5NP_005247.1  growth arrest-specific protein 2 isoform a

    See identical proteins and their annotated locations for NP_005247.1

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801
    Consensus CDS
    CCDS7858.1
    UniProtKB/Swiss-Prot
    O43903
    Conserved Domains (2) summary
    smart00243
    Location:200273
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2
  9. NM_177553.4NP_808221.1  growth arrest-specific protein 2 isoform a

    See identical proteins and their annotated locations for NP_808221.1

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801
    Consensus CDS
    CCDS7858.1
    UniProtKB/Swiss-Prot
    O43903
    Related
    ENSP00000278187.3, ENST00000278187.7
    Conserved Domains (2) summary
    smart00243
    Location:200273
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2

RNA

  1. NR_147085.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006299, AC103801, AI374985

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    22627758..22885930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519972.3XP_011518274.1  growth arrest-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011518274.1

    Conserved Domains (2) summary
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2
    cl02524
    Location:200291
    GAS2; Growth-Arrest-Specific Protein 2 Domain
  2. XM_017017532.1XP_016873021.1  growth arrest-specific protein 2 isoform X2

  3. XM_011519971.3XP_011518273.1  growth arrest-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011518273.1

    Conserved Domains (2) summary
    cd21267
    Location:29163
    CH_GAS2; calponin homology (CH) domain found in growth arrest-specific protein 2
    cl02524
    Location:200291
    GAS2; Growth-Arrest-Specific Protein 2 Domain
  4. XM_011519975.1XP_011518277.1  growth arrest-specific protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011518277.1

    Related
    ENSP00000435946.1, ENST00000532398.1
    Conserved Domains (2) summary
    cd00014
    Location:35157
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl02524
    Location:200242
    GAS2; Growth-Arrest-Specific Protein 2 Domain

RNA

  1. XR_001747829.1 RNA Sequence

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