U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [ Homo sapiens (human) ]

Gene ID: 26115, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TANC2provided by HGNC
Official Full Name
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by HGNC
Primary source
HGNC:HGNC:30212
See related
Ensembl:ENSG00000170921 MIM:615047; AllianceGenome:HGNC:30212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
rols; ROLSA; IDDALDS
Summary
Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Predicted to act upstream of or within in utero embryonic development. Located in dendritic spine. Implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in brain (RPKM 6.5), testis (RPKM 5.9) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TANC2 in Genome Data Viewer
Location:
17q23.2-q23.3
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62966235..63427703)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63836303..64297911)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61043596..61505064)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8814 Neighboring gene tRNA methyltransferase subunit 11-2 pseudogene 3 Neighboring gene microRNA 633 Neighboring gene Sharpr-MPRA regulatory region 13093 Neighboring gene NANOG hESC enhancer GRCh37_chr17:61122317-61122818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61143140-61143657 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61143658-61144174 Neighboring gene zinc finger protein pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:61259160-61260359 Neighboring gene DNAJB6 pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61310050-61310550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61310551-61311051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61382271-61382865 Neighboring gene NANOG hESC enhancer GRCh37_chr17:61423641-61424164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61438304-61438804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61438805-61439305 Neighboring gene DENR pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 4360 Neighboring gene uncharacterized LOC105371856 Neighboring gene Sharpr-MPRA regulatory region 7022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61503073-61503811 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:61512442-61512609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61513919-61514833 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61514834-61515748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61524253-61525066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61525067-61525879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61528047-61528547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61533342-61534200 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61534201-61535059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12545 Neighboring gene cytochrome b561 Neighboring gene peptidylprolyl isomerase A pseudogene 55

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dynamic scaffolds for neuronal signaling: in silico analysis of the TANC protein family. Gasparini A, et al. Sci Rep, 2017 Jul 28. PMID 28754924, Free PMC Article
  2. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. Kim SG, et al. Nat Commun, 2021 May 11. PMID 33976205, Free PMC Article
  3. Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders. Guo H, et al. Nat Commun, 2019 Oct 15. PMID 31616000, Free PMC Article
  4. HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation. Broniarczyk JK, et al. J Virol, 2022 Nov 23. PMID 36326272, Free PMC Article
  5. A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation. Mahmood SF, et al. Carcinogenesis, 2014 Mar. PMID 24148822

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation.
    Title: HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation.
  2. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
    Title: Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
  3. Pediatric patients with disruptive TANC2 mutations present with autism, intellectual disability, and delayed language and motor development. In addition to a variable degree of epilepsy and facial dysmorphism, we observe a pattern of more complex psychiatric dysfunction or behavioral problems in adult probands or carrier parents.
    Title: Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.
  4. -RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3 and TANC2 on chromosome 17q23-were confirmed to be driver genes regulating the proliferation/survival of clonogenic breast cancer cells
    Title: A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.
  5. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
    Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ10215, FLJ11824, KIAA1148, KIAA1636, DKFZp564D166

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in dense core granule cytoskeletal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein TANC2
Names
putative ankyrin-repeat containing protein
rolling pebbles homolog B
tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394998.1 → NP_001381927.1  protein TANC2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005828, AC005972, AC006270, AC015923
    Consensus CDS
    CCDS92376.1
    UniProtKB/TrEMBL
    A0A8I5KXR5
    Related
    ENSP00000510600.1, ENST00000689528.1
    Conserved Domains (6) summary
    PHA03095
    Location:930 → 1224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1511 → 1740
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1324 → 1459
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1170 → 1296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1331 → 1356
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]

  2. NM_001411076.1 → NP_001398005.1  protein TANC2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005828, AC005972, AC006270, AC015923
    Consensus CDS
    CCDS92375.1
    Related
    ENSP00000374171.4, ENST00000389520.8

  3. NM_025185.4 → NP_079461.2  protein TANC2 isoform 1

    See identical proteins and their annotated locations for NP_079461.2

    Status: VALIDATED

    Source sequence(s)
    AC005828, AC005972, AC006270, AC015923
    Consensus CDS
    CCDS45754.1
    UniProtKB/Swiss-Prot
    Q9HAC3, Q9HCD6, Q9NW88, Q9NXY9, Q9ULS2
    Related
    ENSP00000387593.2, ENST00000424789.6
    Conserved Domains (10) summary
    cd00204
    Location:1094 → 1219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1247 → 1272
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1402 → 1629
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1104 → 1196
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:1427 → 1498
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:341 → 383
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1293 → 1356
    TPR_11; TPR repeat
    pfam13428
    Location:1326 → 1368
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:888 → 937
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1100 → 1130
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    62966235..63427703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524597.3 → XP_011522899.1  protein TANC2 isoform X1

    Conserved Domains (9) summary
    cd00204
    Location:1168 → 1293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1331 → 1356
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1487 → 1714
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1178 → 1270
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:1512 → 1583
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:415 → 457
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1377 → 1441
    TPR_11; TPR repeat
    pfam13637
    Location:962 → 1011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]

  2. XM_006721810.4 → XP_006721873.1  protein TANC2 isoform X16

    UniProtKB/TrEMBL
    J3KRP9
    Conserved Domains (5) summary
    cd00204
    Location:1168 → 1293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:1178 → 1270
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:415 → 457
    AAA_16; AAA ATPase domain
    pfam13637
    Location:962 → 1011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]

  3. XM_011524598.3 → XP_011522900.1  protein TANC2 isoform X2

    Conserved Domains (9) summary
    cd00204
    Location:1168 → 1293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1321 → 1346
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1477 → 1704
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1178 → 1270
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:1502 → 1573
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:415 → 457
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1367 → 1431
    TPR_11; TPR repeat
    pfam13637
    Location:962 → 1011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]

  4. XM_006721807.4 → XP_006721870.1  protein TANC2 isoform X3

    Conserved Domains (10) summary
    cd00204
    Location:1168 → 1293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1321 → 1346
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1476 → 1703
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1178 → 1270
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:1501 → 1572
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:415 → 457
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1367 → 1430
    TPR_11; TPR repeat
    pfam13428
    Location:1400 → 1442
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:962 → 1011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]

  5. XM_006721811.5 → XP_006721874.1  protein TANC2 isoform X17

    UniProtKB/TrEMBL
    J3KRP9
    Conserved Domains (5) summary
    cd00204
    Location:1168 → 1293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:1178 → 1270
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:415 → 457
    AAA_16; AAA ATPase domain
    pfam13637
    Location:962 → 1011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]

  6. XM_011524600.3 → XP_011522902.1  protein TANC2 isoform X6

    Conserved Domains (9) summary
    cd00204
    Location:1131 → 1256
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1294 → 1319
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1450 → 1677
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1141 → 1233
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:1475 → 1546
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:378 → 420
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1340 → 1404
    TPR_11; TPR repeat
    pfam13637
    Location:925 → 974
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1137 → 1167
    ANK; ANK repeat [structural motif]

  7. XM_047435731.1 → XP_047291687.1  protein TANC2 isoform X8

  8. XM_047435733.1 → XP_047291689.1  protein TANC2 isoform X10

  9. XM_047435734.1 → XP_047291690.1  protein TANC2 isoform X11

  10. XM_047435738.1 → XP_047291694.1  protein TANC2 isoform X18

    Related
    ENSP00000462109.1, ENST00000583356.5

  11. XM_011524601.3 → XP_011522903.1  protein TANC2 isoform X7

    Conserved Domains (9) summary
    cd00204
    Location:1131 → 1256
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1294 → 1319
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1450 → 1677
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1141 → 1233
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:1475 → 1546
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:378 → 420
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1340 → 1404
    TPR_11; TPR repeat
    pfam13637
    Location:925 → 974
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1137 → 1167
    ANK; ANK repeat [structural motif]

  12. XM_047435732.1 → XP_047291688.1  protein TANC2 isoform X9

  13. XM_011524602.3 → XP_011522904.1  protein TANC2 isoform X13

    Conserved Domains (9) summary
    cd00204
    Location:1094 → 1219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1257 → 1282
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1413 → 1640
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1104 → 1196
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:1438 → 1509
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:341 → 383
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1303 → 1367
    TPR_11; TPR repeat
    pfam13637
    Location:888 → 937
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1100 → 1130
    ANK; ANK repeat [structural motif]

  14. XM_011524599.2 → XP_011522901.1  protein TANC2 isoform X4

    Conserved Domains (9) summary
    cd00204
    Location:1152 → 1277
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1315 → 1340
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1471 → 1698
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1162 → 1254
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:1496 → 1567
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:399 → 441
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1361 → 1425
    TPR_11; TPR repeat
    pfam13637
    Location:946 → 995
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1158 → 1188
    ANK; ANK repeat [structural motif]

  15. XM_017024429.2 → XP_016879918.1  protein TANC2 isoform X5

  16. XM_047435735.1 → XP_047291691.1  protein TANC2 isoform X12

  17. XM_047435737.1 → XP_047291693.1  protein TANC2 isoform X14

  18. XM_017024430.3 → XP_016879919.1  protein TANC2 isoform X15

    Conserved Domains (9) summary
    cd00204
    Location:1004 → 1129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1167 → 1192
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1323 → 1550
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1014 → 1106
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:1348 → 1419
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:251 → 293
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1213 → 1277
    TPR_11; TPR repeat
    pfam13637
    Location:798 → 847
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1010 → 1040
    ANK; ANK repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    63836303..64297911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315677.1 → XP_054171652.1  protein TANC2 isoform X1

  2. XM_054315678.1 → XP_054171653.1  protein TANC2 isoform X2

  3. XM_054315682.1 → XP_054171657.1  protein TANC2 isoform X6

  4. XM_054315686.1 → XP_054171661.1  protein TANC2 isoform X10

  5. XM_054315683.1 → XP_054171658.1  protein TANC2 isoform X7

  6. XM_054315689.1 → XP_054171664.1  protein TANC2 isoform X13

  7. XM_054315692.1 → XP_054171667.1  protein TANC2 isoform X16

  8. XM_054315679.1 → XP_054171654.1  protein TANC2 isoform X3

  9. XM_054315693.1 → XP_054171668.1  protein TANC2 isoform X17

  10. XM_054315684.1 → XP_054171659.1  protein TANC2 isoform X8

  11. XM_054315687.1 → XP_054171662.1  protein TANC2 isoform X11

  12. XM_054315694.1 → XP_054171669.1  protein TANC2 isoform X18

  13. XM_054315685.1 → XP_054171660.1  protein TANC2 isoform X9

  14. XM_054315680.1 → XP_054171655.1  protein TANC2 isoform X4

  15. XM_054315688.1 → XP_054171663.1  protein TANC2 isoform X12

  16. XM_054315690.1 → XP_054171665.1  protein TANC2 isoform X14

  17. XM_054315681.1 → XP_054171656.1  protein TANC2 isoform X5

  18. XM_054315691.1 → XP_054171666.1  protein TANC2 isoform X15

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015623.2: Suppressed sequence

    Description
    NM_015623.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.

  2. NM_030658.2: Suppressed sequence

    Description
    NM_030658.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HCD6.3 GenPept UniProtKB/Swiss-Prot:Q9HCD6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools