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TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [ Homo sapiens (human) ]

Gene ID: 26115, updated on 2-Oct-2018

Summary

Official Symbol
TANC2provided by HGNC
Official Full Name
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by HGNC
Primary source
HGNC:HGNC:30212
See related
Ensembl:ENSG00000170921 MIM:615047; Vega:OTTHUMG00000179103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
rols; ROLSA
Expression
Broad expression in brain (RPKM 6.5), testis (RPKM 5.9) and 23 other tissues See more
Orthologs

Genomic context

See TANC2 in Genome Data Viewer
Location:
17q23.2-q23.3
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (62966523..63427706)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61043913..61505067)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase subunit 11-2 pseudogene 3 Neighboring gene microRNA 633 Neighboring gene zinc finger protein pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 pseudogene Neighboring gene density regulated re-initiation and release factor pseudogene Neighboring gene uncharacterized LOC105371857 Neighboring gene uncharacterized LOC105371856 Neighboring gene uncharacterized LOC107983996 Neighboring gene cytochrome b561 Neighboring gene peptidylprolyl isomerase A pseudogene 55

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10215, FLJ11824, KIAA1148, KIAA1636, DKFZp564D166

Gene Ontology Provided by GOA

Process Evidence Code Pubs
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein TANC2
Names
putative ankyrin-repeat containing protein
rolling pebbles homolog B
tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025185.3NP_079461.2  protein TANC2

    See identical proteins and their annotated locations for NP_079461.2

    Status: VALIDATED

    Source sequence(s)
    AC005828, AC005972, AC006270, AC015923
    Consensus CDS
    CCDS45754.1
    UniProtKB/Swiss-Prot
    Q9HCD6
    Related
    ENSP00000387593.2, OTTHUMP00000260681, ENST00000424789.6, OTTHUMT00000444765
    Conserved Domains (10) summary
    cd00204
    Location:10941219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:12471272
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14021629
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11041196
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:14271498
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:341383
    AAA_16; AAA ATPase domain
    pfam13414
    Location:12931356
    TPR_11; TPR repeat
    pfam13428
    Location:13261368
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:888937
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11001130
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    62966523..63427706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524597.2XP_011522899.1  protein TANC2 isoform X1

    Conserved Domains (9) summary
    cd00204
    Location:11681293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:13311356
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14871714
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11781270
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:15121583
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:415457
    AAA_16; AAA ATPase domain
    pfam13414
    Location:13771441
    TPR_11; TPR repeat
    pfam13637
    Location:9621011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
  2. XM_006721806.3XP_006721869.1  protein TANC2 isoform X2

    Conserved Domains (10) summary
    cd00204
    Location:11681293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:13311356
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14861713
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11781270
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:15111582
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:415457
    AAA_16; AAA ATPase domain
    pfam13414
    Location:13771440
    TPR_11; TPR repeat
    pfam13428
    Location:14101452
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:9621011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
  3. XM_011524598.2XP_011522900.1  protein TANC2 isoform X3

    Conserved Domains (9) summary
    cd00204
    Location:11681293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:13211346
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14771704
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11781270
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:15021573
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:415457
    AAA_16; AAA ATPase domain
    pfam13414
    Location:13671431
    TPR_11; TPR repeat
    pfam13637
    Location:9621011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
  4. XM_006721807.3XP_006721870.1  protein TANC2 isoform X4

    Conserved Domains (10) summary
    cd00204
    Location:11681293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:13211346
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14761703
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11781270
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:15011572
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:415457
    AAA_16; AAA ATPase domain
    pfam13414
    Location:13671430
    TPR_11; TPR repeat
    pfam13428
    Location:14001442
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:9621011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
  5. XM_006721811.4XP_006721874.1  protein TANC2 isoform X13

    Related
    ENSP00000462109.1, OTTHUMP00000260685, ENST00000583356.5
    Conserved Domains (5) summary
    cd00204
    Location:11681293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11781270
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:415457
    AAA_16; AAA ATPase domain
    pfam13637
    Location:9621011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
  6. XM_011524600.2XP_011522902.1  protein TANC2 isoform X7

    Conserved Domains (9) summary
    cd00204
    Location:11311256
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:12941319
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14501677
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11411233
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:14751546
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:378420
    AAA_16; AAA ATPase domain
    pfam13414
    Location:13401404
    TPR_11; TPR repeat
    pfam13637
    Location:925974
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11371167
    ANK; ANK repeat [structural motif]
  7. XM_011524601.2XP_011522903.1  protein TANC2 isoform X8

    Conserved Domains (9) summary
    cd00204
    Location:11311256
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:12941319
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14501677
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11411233
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:14751546
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:378420
    AAA_16; AAA ATPase domain
    pfam13414
    Location:13401404
    TPR_11; TPR repeat
    pfam13637
    Location:925974
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11371167
    ANK; ANK repeat [structural motif]
  8. XM_011524602.2XP_011522904.1  protein TANC2 isoform X9

    Conserved Domains (9) summary
    cd00204
    Location:10941219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:12571282
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14131640
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11041196
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:14381509
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:341383
    AAA_16; AAA ATPase domain
    pfam13414
    Location:13031367
    TPR_11; TPR repeat
    pfam13637
    Location:888937
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11001130
    ANK; ANK repeat [structural motif]
  9. XM_005257203.4XP_005257260.1  protein TANC2 isoform X10

    See identical proteins and their annotated locations for XP_005257260.1

    UniProtKB/Swiss-Prot
    Q9HCD6
    Conserved Domains (10) summary
    cd00204
    Location:10941219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:12471272
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14021629
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11041196
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:14271498
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:341383
    AAA_16; AAA ATPase domain
    pfam13414
    Location:12931356
    TPR_11; TPR repeat
    pfam13428
    Location:13261368
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:888937
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11001130
    ANK; ANK repeat [structural motif]
  10. XM_006721810.3XP_006721873.1  protein TANC2 isoform X12

    Conserved Domains (5) summary
    cd00204
    Location:11681293
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:11781270
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:415457
    AAA_16; AAA ATPase domain
    pfam13637
    Location:9621011
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
  11. XM_017024431.1XP_016879920.1  protein TANC2 isoform X14

  12. XM_011524599.1XP_011522901.1  protein TANC2 isoform X5

    Conserved Domains (9) summary
    cd00204
    Location:11521277
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:13151340
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14711698
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11621254
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:14961567
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:399441
    AAA_16; AAA ATPase domain
    pfam13414
    Location:13611425
    TPR_11; TPR repeat
    pfam13637
    Location:946995
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11581188
    ANK; ANK repeat [structural motif]
  13. XM_017024429.1XP_016879918.1  protein TANC2 isoform X6

  14. XM_017024430.2XP_016879919.1  protein TANC2 isoform X11

    Conserved Domains (9) summary
    cd00204
    Location:10041129
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:11671192
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:13231550
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:10141106
    Ank_2; Ankyrin repeats (3 copies)
    pfam12859
    Location:13481419
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam13191
    Location:251293
    AAA_16; AAA ATPase domain
    pfam13414
    Location:12131277
    TPR_11; TPR repeat
    pfam13637
    Location:798847
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:10101040
    ANK; ANK repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015623.2: Suppressed sequence

    Description
    NM_015623.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
  2. NM_030658.2: Suppressed sequence

    Description
    NM_030658.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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