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Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [ Mus musculus (house mouse) ]

Gene ID: 77097, updated on 21-Apr-2024

Summary

Official Symbol
Tanc2provided by MGI
Official Full Name
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by MGI
Primary source
MGI:MGI:2444121
See related
Ensembl:ENSMUSG00000053580 AllianceGenome:MGI:2444121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3526402J09Rik; 5730590C14Rik
Summary
Acts upstream of or within in utero embryonic development. Predicted to be located in axon; cytosol; and dendritic spine. Orthologous to human TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 11.5), CNS E18 (RPKM 11.4) and 19 other tissues See more
Orthologs
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Genomic context

Location:
11 E1; 11 68.73 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105480458..105820130)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105589460..105929304)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30908 Neighboring gene predicted gene, 35828 Neighboring gene predicted gene, 39422 Neighboring gene STARR-positive B cell enhancer mm9_chr11:105453342-105453643 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30909 Neighboring gene STARR-seq mESC enhancer starr_30910 Neighboring gene snurportin 1 pseudogene Neighboring gene predicted gene, 53650 Neighboring gene STARR-seq mESC enhancer starr_30912 Neighboring gene cytochrome b-561 Neighboring gene predicted gene 9910 Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein TANC2
Names
tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181071.3NP_851416.2  protein TANC2

    See identical proteins and their annotated locations for NP_851416.2

    Status: VALIDATED

    Source sequence(s)
    AI413677, AK051973, AK173111, AL596246, BP766228
    Consensus CDS
    CCDS36357.1
    UniProtKB/Swiss-Prot
    A2A683, A2A690, Q3TRZ3, Q5EBP6, Q69ZQ7
    Related
    ENSMUSP00000097904.4, ENSMUST00000100330.10
    Conserved Domains (10) summary
    cd00204
    Location:10941219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:12471272
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:14081633
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:11041196
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:341383
    AAA_16; AAA ATPase domain
    pfam13414
    Location:12931356
    TPR_11; TPR repeat
    pfam13428
    Location:13261368
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:888937
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:11001130
    ANK; ANK repeat [structural motif]
    cl14876
    Location:395539
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105480458..105820130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534472.4XP_006534535.1  protein TANC2 isoform X1

    Conserved Domains (7) summary
    PHA03095
    Location:9301224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:15151745
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:13241442
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:11701296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:13311356
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415500
    AAA_16; AAA ATPase domain
  2. XM_006534473.4XP_006534536.1  protein TANC2 isoform X2

    Conserved Domains (7) summary
    PHA03095
    Location:9301224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:15141744
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:13241441
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:11701296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:13311356
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415500
    AAA_16; AAA ATPase domain
  3. XM_006534482.5XP_006534545.1  protein TANC2 isoform X9

    Conserved Domains (4) summary
    PHA03095
    Location:9301224
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:11701296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415500
    AAA_16; AAA ATPase domain
  4. XM_006534474.4XP_006534537.1  protein TANC2 isoform X3

    Conserved Domains (7) summary
    PHA03095
    Location:9301224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:15051735
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:13141432
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:11701296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:13211346
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415500
    AAA_16; AAA ATPase domain
  5. XM_006534475.4XP_006534538.1  protein TANC2 isoform X4

    Conserved Domains (7) summary
    PHA03095
    Location:9301224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:15041734
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:13141431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:11701296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:13211346
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415500
    AAA_16; AAA ATPase domain
  6. XM_006534483.5XP_006534546.1  protein TANC2 isoform X10

    Conserved Domains (5) summary
    PHA03095
    Location:10831303
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:8781046
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:11741204
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:11781270
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:415500
    AAA_16; AAA ATPase domain
  7. XM_006534476.4XP_006534539.1  protein TANC2 isoform X5

    Conserved Domains (7) summary
    PHA03095
    Location:8931187
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:14781708
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:12871405
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:11331259
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:12941319
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11371167
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:378463
    AAA_16; AAA ATPase domain
  8. XM_006534477.4XP_006534540.1  protein TANC2 isoform X6

    Conserved Domains (7) summary
    PHA03095
    Location:8931187
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12871405
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:11331259
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:12941319
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11371167
    ANK; ANK repeat [structural motif]
    pfam15240
    Location:14931645
    Pro-rich; Proline-rich
    pfam13191
    Location:378463
    AAA_16; AAA ATPase domain
  9. XM_006534478.3XP_006534541.1  protein TANC2 isoform X7

    Conserved Domains (7) summary
    PHA03095
    Location:8561150
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:12501368
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:10961222
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:12571282
    TPR; TPR repeat [structural motif]
    sd00045
    Location:11001130
    ANK; ANK repeat [structural motif]
    pfam15240
    Location:14561608
    Pro-rich; Proline-rich
    pfam13191
    Location:341426
    AAA_16; AAA ATPase domain
  10. XM_006534480.5XP_006534543.1  protein TANC2 isoform X8

    See identical proteins and their annotated locations for XP_006534543.1

    Conserved Domains (7) summary
    PHA03095
    Location:7661060
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:11601278
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:10061132
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:11671192
    TPR; TPR repeat [structural motif]
    sd00045
    Location:10101040
    ANK; ANK repeat [structural motif]
    pfam15240
    Location:13661518
    Pro-rich; Proline-rich
    pfam13191
    Location:251336
    AAA_16; AAA ATPase domain
  11. XM_006534481.5XP_006534544.1  protein TANC2 isoform X8

    See identical proteins and their annotated locations for XP_006534544.1

    Conserved Domains (7) summary
    PHA03095
    Location:7661060
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:11601278
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:10061132
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:11671192
    TPR; TPR repeat [structural motif]
    sd00045
    Location:10101040
    ANK; ANK repeat [structural motif]
    pfam15240
    Location:13661518
    Pro-rich; Proline-rich
    pfam13191
    Location:251336
    AAA_16; AAA ATPase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175492.2: Suppressed sequence

    Description
    NM_175492.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.