Format

Send to:

Choose Destination

PYGO1 pygopus family PHD finger 1 [ Homo sapiens (human) ]

Gene ID: 26108, updated on 3-Feb-2021

Summary

Official Symbol
PYGO1provided by HGNC
Official Full Name
pygopus family PHD finger 1provided by HGNC
Primary source
HGNC:HGNC:30256
See related
Ensembl:ENSG00000171016 MIM:606902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in thyroid (RPKM 4.1), endometrium (RPKM 3.0) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PYGO1 in Genome Data Viewer
Location:
15q21.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (55538884..55588971, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (55831082..55881169, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene DNAAF4-CCPG1 readthrough (NMD candidate) Neighboring gene thioesterase superfamily member 4 pseudogene Neighboring gene chromosome 15 open reading frame 65 Neighboring gene dynein axonemal assembly factor 4 Neighboring gene protogenin Neighboring gene NEDD4 intron nontranscribed DNase I hypersensitive site-defined enhancer Neighboring gene NEDD4 E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30808, FLJ38221, DKFZp547G0910, DKFZp686P07116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
beta-catenin-TCF complex assembly TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
kidney development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
spermatid nucleus differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
pygopus homolog 1
Names
pygopus-like protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330326.2NP_001317255.1  pygopus homolog 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTRs, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is the same length as isoform 1, but has a distinct N-terminus.
    Source sequence(s)
    AC012378, AC022083
    Consensus CDS
    CCDS81885.1
    UniProtKB/Swiss-Prot
    Q9Y3Y4
    Related
    ENSP00000496139.1, ENST00000645724.1
    Conserved Domains (1) summary
    cd15635
    Location:341397
    PHD_PYGO1; PHD finger found in pygopus homolog 1 (PYGO1)
  2. NM_001367806.1NP_001354735.1  pygopus homolog 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012378, AC022083
    Related
    ENSP00000457777.1, ENST00000563719.3
  3. NM_015617.3NP_056432.1  pygopus homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_056432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC012378, AC022083, AF457207
    Consensus CDS
    CCDS10155.1
    UniProtKB/Swiss-Prot
    Q9Y3Y4
    Related
    ENSP00000302327.6, ENST00000302000.10
    Conserved Domains (1) summary
    cd15635
    Location:341397
    PHD_PYGO1; PHD finger found in pygopus homolog 1 (PYGO1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    55538884..55588971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center