Format

Send to:

Choose Destination

DCAF4 DDB1 and CUL4 associated factor 4 [ Homo sapiens (human) ]

Gene ID: 26094, updated on 1-Jun-2020

Summary

Official Symbol
DCAF4provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 4provided by HGNC
Primary source
HGNC:HGNC:20229
See related
Ensembl:ENSG00000119599 MIM:616372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR21; WDR21A
Summary
This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Expression
Ubiquitous expression in thyroid (RPKM 4.7), testis (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See DCAF4 in Genome Data Viewer
Location:
14q24.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (72926337..72962098)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (73393040..73428825)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene double PHD fingers 3 Neighboring gene Sharpr-MPRA regulatory region 237 Neighboring gene uncharacterized LOC107984711 Neighboring gene ribosomal protein L36 pseudogene 3 Neighboring gene chromosome 17 open reading frame 98 pseudogene Neighboring gene tRNA-Cys (anticodon GCA) 8-1 Neighboring gene ribosomal protein S12 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20547, MGC46524, DKFZp434K114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 4
Names
WD repeat domain 21A
WD repeat-containing protein 21A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047140.1 RefSeqGene

    Range
    5133..38372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001163508.2NP_001156980.1  DDB1- and CUL4-associated factor 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate in-frame splice sites in the coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
    Source sequence(s)
    AK027745, AK315499, AL442663, BC018979, DC314513
    Consensus CDS
    CCDS55926.1
    UniProtKB/Swiss-Prot
    Q8WV16
    UniProtKB/TrEMBL
    B2RDD6
    Related
    ENSP00000452131.1, ENST00000555042.5
    Conserved Domains (3) summary
    COG2319
    Location:310475
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:286316
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:363463
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001163509.2NP_001156981.1  DDB1- and CUL4-associated factor 4 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses two alternate splice sites in the coding region and uses an alternate translational start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK027745, AK297742, AL442663, BC018979, DC314513
    UniProtKB/Swiss-Prot
    Q8WV16
    UniProtKB/TrEMBL
    B4DN30
    Conserved Domains (3) summary
    COG2319
    Location:265460
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:264301
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:265448
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001352447.2NP_001339376.1  DDB1- and CUL4-associated factor 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC007160, AL442663
    Conserved Domains (2) summary
    sd00039
    Location:71108
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:124255
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001352448.2NP_001339377.1  DDB1- and CUL4-associated factor 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC007160, AL442663
    Conserved Domains (2) summary
    sd00039
    Location:285322
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:315434
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_001352449.2NP_001339378.1  DDB1- and CUL4-associated factor 4 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes the longest isoform (8).
    Source sequence(s)
    AC007160, AL442663
    Conserved Domains (2) summary
    sd00039
    Location:286323
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:287470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_015604.4NP_056419.2  DDB1- and CUL4-associated factor 4 isoform 1

    See identical proteins and their annotated locations for NP_056419.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK027745, AK315499, AL442663, BC018979, DC314513
    Consensus CDS
    CCDS9809.1
    UniProtKB/Swiss-Prot
    Q8WV16
    UniProtKB/TrEMBL
    B2RDD6
    Related
    ENSP00000351147.2, ENST00000358377.7
    Conserved Domains (3) summary
    COG2319
    Location:301481
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:285322
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:286469
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_181340.3NP_851937.1  DDB1- and CUL4-associated factor 4 isoform 2

    See identical proteins and their annotated locations for NP_851937.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK027745, AL442663, BC018979, BC035901, DC314513
    Consensus CDS
    CCDS9810.1
    UniProtKB/Swiss-Prot
    Q8WV16
    Related
    ENSP00000377781.2, ENST00000394234.6
    Conserved Domains (2) summary
    sd00039
    Location:185222
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:186369
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. NM_181341.3NP_851938.2  DDB1- and CUL4-associated factor 4 isoform 3

    See identical proteins and their annotated locations for NP_851938.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks two alternate exons in the coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AK027745, AK300786, AL442663, BC018979, DC314513
    Consensus CDS
    CCDS41968.2
    UniProtKB/Swiss-Prot
    Q8WV16
    Related
    ENSP00000426178.1, ENST00000509153.5
    Conserved Domains (3) summary
    COG2319
    Location:241421
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:225262
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:278409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_147990.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007160, AL442663

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    72926337..72962098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021209.1XP_016876698.1  DDB1- and CUL4-associated factor 4 isoform X3

  2. XM_017021208.1XP_016876697.1  DDB1- and CUL4-associated factor 4 isoform X2

    UniProtKB/Swiss-Prot
    Q8WV16
    Conserved Domains (3) summary
    COG2319
    Location:301481
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:285322
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:286469
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_017021203.1XP_016876692.1  DDB1- and CUL4-associated factor 4 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:286323
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:287470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_017021207.1XP_016876696.1  DDB1- and CUL4-associated factor 4 isoform X2

    UniProtKB/Swiss-Prot
    Q8WV16
    Conserved Domains (3) summary
    COG2319
    Location:301481
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:285322
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:286469
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_017021214.1XP_016876703.1  DDB1- and CUL4-associated factor 4 isoform X5

  6. XM_017021215.2XP_016876704.1  DDB1- and CUL4-associated factor 4 isoform X6

  7. XM_017021205.1XP_016876694.1  DDB1- and CUL4-associated factor 4 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:286323
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:287470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_017021212.1XP_016876701.1  DDB1- and CUL4-associated factor 4 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:265460
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:264301
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:265448
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_017021206.1XP_016876695.1  DDB1- and CUL4-associated factor 4 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:286323
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:287470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_017021213.2XP_016876702.1  DDB1- and CUL4-associated factor 4 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:265460
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:264301
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:265448
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_017021202.1XP_016876691.1  DDB1- and CUL4-associated factor 4 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:286323
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:287470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  12. XM_017021201.1XP_016876690.1  DDB1- and CUL4-associated factor 4 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:286323
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:287470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Support Center