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Dcaf4 DDB1 and CUL4 associated factor 4 [ Mus musculus (house mouse) ]

Gene ID: 73828, updated on 26-Sep-2022

Summary

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Official Symbol
Dcaf4provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 4provided by MGI
Primary source
MGI:MGI:1921078
See related
Ensembl:ENSMUSG00000021222 AllianceGenome:MGI:1921078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr21; 1110018E21Rik
Summary
Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in adrenal medulla; alimentary system; epidermis; genitourinary system; and sensory organ. Orthologous to several human genes including DCAF4 (DDB1 and CUL4 associated factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 8.8), CNS E18 (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dcaf4 in Genome Data Viewer
Location:
12; 12 D1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (83567145..83588768)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83520447..83541994)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53731 Neighboring gene double PHD fingers 3 Neighboring gene double PHD fingers 3 Neighboring gene zinc finger, FYVE domain containing 1 Neighboring gene H2A histone family, member Z pseudogene Neighboring gene RNA binding motif protein 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
  2. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 4
Names
WD repeat domain 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165256.1 → NP_001158728.1  DDB1- and CUL4-associated factor 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA763635, AC139382, BE988217, CK330131, CN722277, CX208460
    Consensus CDS
    CCDS88367.1
    UniProtKB/TrEMBL
    A0A1Y7VNZ0
    Related
    ENSMUSP00000152717.2, ENSMUST00000223291.2
    Conserved Domains (3) summary
    COG2319
    Location:315 → 484
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:299 → 335
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:327 → 484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_030246.2 → NP_084522.1  DDB1- and CUL4-associated factor 4 isoform 2

    See identical proteins and their annotated locations for NP_084522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA763635, AC139382, BB852314, BE988217, CK330131, CN722277, CX208460
    Consensus CDS
    CCDS26027.1
    UniProtKB/TrEMBL
    Q99LF7
    Related
    ENSMUSP00000021645.8, ENSMUST00000021645.9
    Conserved Domains (2) summary
    sd00039
    Location:286 → 322
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:314 → 471
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    83567145..83588768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246953.2 → XP_030102813.1  DDB1- and CUL4-associated factor 4 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:285 → 321
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:313 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_036157629.1 → XP_036013522.1  DDB1- and CUL4-associated factor 4 isoform X2

    UniProtKB/TrEMBL
    Q99LF7
    Conserved Domains (2) summary
    sd00039
    Location:286 → 322
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:314 → 471
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_036157630.1 → XP_036013523.1  DDB1- and CUL4-associated factor 4 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:285 → 321
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:313 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_030246954.2 → XP_030102814.1  DDB1- and CUL4-associated factor 4 isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:133 → 169
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:161 → 318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_006516284.3 → XP_006516347.1  DDB1- and CUL4-associated factor 4 isoform X5

    Conserved Domains (2) summary
    sd00039
    Location:71 → 107
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:99 → 256
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_030246955.2 → XP_030102815.1  DDB1- and CUL4-associated factor 4 isoform X6

    Conserved Domains (2) summary
    sd00039
    Location:70 → 106
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:98 → 255
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_006516282.3 → XP_006516345.1  DDB1- and CUL4-associated factor 4 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:298 → 334
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:326 → 483
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_036157631.1 → XP_036013524.1  DDB1- and CUL4-associated factor 4 isoform X5

    Conserved Domains (2) summary
    sd00039
    Location:71 → 107
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:99 → 256
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_006516283.4 → XP_006516346.1  DDB1- and CUL4-associated factor 4 isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:133 → 169
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:161 → 318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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