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GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 [ Homo sapiens (human) ]

Gene ID: 26088, updated on 14-Jun-2018
Official Symbol
GGA1provided by HGNC
Official Full Name
golgi associated, gamma adaptin ear containing, ARF binding protein 1provided by HGNC
Primary source
HGNC:HGNC:17842
See related
Ensembl:ENSG00000100083 MIM:606004; Vega:OTTHUMG00000030985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 36.8), spleen (RPKM 8.3) and 23 other tissues See more
Orthologs
See GGA1 in Genome Data Viewer
Location:
22q13.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (37608474..37633564)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38004481..38029571)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene HNF1 motif-containing MPRA enhancer 93 Neighboring gene galectin 2 Neighboring gene uncharacterized LOC101927051 Neighboring gene SH3 domain binding protein 1 Neighboring gene pyridoxal phosphatase

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies GGA1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
Pr55(Gag) gag GGA1 overexpression severely reduces virus particle production by impairing Gag trafficking to the membrane, an effect that requires the MA domain of Gag PubMed
gag GGA1-induced, but not GGA2- or GGA3-induced, compartments accumulate unprocessed Gag and virus-like particles PubMed
Vpr vpr Expression of a patient-derived HIV-1 Vpr protein reveals a significant reduction in Vpr nuclear import. Vpr F72L mutation is responsible for this decreased Vpr nuclear import and the F72L mutant is co-localized with gamma-adaptin in the Golgi apparatus PubMed
matrix gag GGA1 overexpression severely reduces virus particle production by impairing Gag trafficking to the membrane, which requires the MA domain of Gag PubMed

Go to the HIV-1, Human Interaction Database

  • Amyloid fiber formation, organism-specific biosystem (from REACTOME)
    Amyloid fiber formation, organism-specific biosystemAmyloid is a term used to describe deposits of fibrillar proteins, typically extracellular. The abnormal accumulation of amyloid, amyloidosis, is a term associated with tissue damage caused by amyloi...
  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
    TBC/RABGAPs, organism-specific biosystemRab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases se...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-ribosylation factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
intracellular protein transport TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
toxin transport IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Preferred Names
ADP-ribosylation factor-binding protein GGA1
Names
ADP-ribosylation factor binding protein 1
gamma-adaptin related protein 1
golgi-localized, gamma ear-containing, ARF-binding protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001560.2NP_001001560.1  ADP-ribosylation factor-binding protein GGA1 isoform 2

    See identical proteins and their annotated locations for NP_001001560.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks 2 in-frame exons in the coding region, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK075256, AL110219, BC044629, DA455573
    Consensus CDS
    CCDS33643.1
    UniProtKB/Swiss-Prot
    Q9UJY5
    Related
    ENSP00000321288.8, OTTHUMP00000214014, ENST00000325180.12, OTTHUMT00000353186
    Conserved Domains (3) summary
    smart00809
    Location:430544
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:9147
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cl03906
    Location:210277
    GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins
  2. NM_001172687.1NP_001166158.1  ADP-ribosylation factor-binding protein GGA1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (4) lacks an internal segment of 4 aa, as compared to isoform 1.
    Source sequence(s)
    AK075256, AL110219, DA455573
    UniProtKB/Swiss-Prot
    Q9UJY5
    Conserved Domains (4) summary
    smart00809
    Location:513627
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:9147
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cd14239
    Location:210299
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl00753
    Location:180234
    DUF327; Protein of unknown function (DUF327)
  3. NM_001172688.1NP_001166159.1  ADP-ribosylation factor-binding protein GGA1 isoform 5

    See identical proteins and their annotated locations for NP_001166159.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK122898, AL110219
    Consensus CDS
    CCDS54526.1
    UniProtKB/Swiss-Prot
    Q9UJY5
    Related
    ENSP00000385287.1, OTTHUMP00000198162, ENST00000406772.5, OTTHUMT00000319455
    Conserved Domains (3) summary
    smart00809
    Location:444558
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd14239
    Location:137226
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl02544
    Location:174
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  4. NM_001363771.1NP_001350700.1  ADP-ribosylation factor-binding protein GGA1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL035496, AL110219, BP225635, CR456493
    Consensus CDS
    CCDS87022.1
  5. NM_013365.4NP_037497.1  ADP-ribosylation factor-binding protein GGA1 isoform 1

    See identical proteins and their annotated locations for NP_037497.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK075256, AL110219, DA455573
    Consensus CDS
    CCDS13951.1
    UniProtKB/Swiss-Prot
    Q9UJY5
    Related
    ENSP00000341344.4, OTTHUMP00000028975, ENST00000343632.8, OTTHUMT00000075873
    Conserved Domains (4) summary
    smart00809
    Location:517631
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:9147
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cd14239
    Location:210299
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl00753
    Location:180234
    DUF327; Protein of unknown function (DUF327)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    37608474..37633564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452213.1XP_024307981.1  ADP-ribosylation factor-binding protein GGA1 isoform X1

    Related
    ENSP00000371175.5, ENST00000381756.9
    Conserved Domains (3) summary
    smart00809
    Location:534648
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:9164
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cd14239
    Location:227316
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
  2. XM_024452214.1XP_024307982.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

    Conserved Domains (3) summary
    smart00809
    Location:447561
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:9164
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cl03906
    Location:227294
    GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins
  3. XM_024452217.1XP_024307985.1  ADP-ribosylation factor-binding protein GGA1 isoform X6

    Conserved Domains (3) summary
    smart00809
    Location:380494
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd14239
    Location:73162
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl00753
    Location:4397
    DUF327; Protein of unknown function (DUF327)
  4. XM_017028763.1XP_016884252.1  ADP-ribosylation factor-binding protein GGA1 isoform X6

    Conserved Domains (3) summary
    smart00809
    Location:380494
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd14239
    Location:73162
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl00753
    Location:4397
    DUF327; Protein of unknown function (DUF327)
  5. XM_006724229.1XP_006724292.1  ADP-ribosylation factor-binding protein GGA1 isoform X5

    See identical proteins and their annotated locations for XP_006724292.1

    UniProtKB/Swiss-Prot
    Q9UJY5
    Conserved Domains (3) summary
    smart00809
    Location:444558
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd14239
    Location:137226
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl02544
    Location:174
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  6. XM_024452215.1XP_024307983.1  ADP-ribosylation factor-binding protein GGA1 isoform X5

    Conserved Domains (3) summary
    smart00809
    Location:444558
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd14239
    Location:137226
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl02544
    Location:174
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  7. XM_005261518.2XP_005261575.1  ADP-ribosylation factor-binding protein GGA1 isoform X3

    Conserved Domains (4) summary
    smart00809
    Location:509623
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:7139
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cd14239
    Location:202291
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl00753
    Location:172226
    DUF327; Protein of unknown function (DUF327)
  8. XM_024452216.1XP_024307984.1  ADP-ribosylation factor-binding protein GGA1 isoform X5

    Conserved Domains (3) summary
    smart00809
    Location:444558
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd14239
    Location:137226
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl02544
    Location:174
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  9. XM_011530123.2XP_011528425.1  ADP-ribosylation factor-binding protein GGA1 isoform X2

    Conserved Domains (4) summary
    smart00809
    Location:526640
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:7156
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cd14239
    Location:219308
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl00753
    Location:189243
    DUF327; Protein of unknown function (DUF327)
  10. XM_017028761.1XP_016884250.1  ADP-ribosylation factor-binding protein GGA1 isoform X5

    UniProtKB/Swiss-Prot
    Q9UJY5
    Conserved Domains (3) summary
    smart00809
    Location:444558
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd14239
    Location:137226
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl02544
    Location:174
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  11. XM_005261520.1XP_005261577.1  ADP-ribosylation factor-binding protein GGA1 isoform X5

    See identical proteins and their annotated locations for XP_005261577.1

    UniProtKB/Swiss-Prot
    Q9UJY5
    Conserved Domains (3) summary
    smart00809
    Location:444558
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd14239
    Location:137226
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl02544
    Location:174
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  12. XM_017028764.1XP_016884253.1  ADP-ribosylation factor-binding protein GGA1 isoform X7

  13. XM_005261522.1XP_005261579.1  ADP-ribosylation factor-binding protein GGA1 isoform X8

    Conserved Domains (2) summary
    smart00809
    Location:267381
    Alpha_adaptinC2; Adaptin C-terminal domain
    cl03906
    Location:2849
    GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins
  14. XM_017028765.1XP_016884254.1  ADP-ribosylation factor-binding protein GGA1 isoform X8

    Conserved Domains (2) summary
    smart00809
    Location:267381
    Alpha_adaptinC2; Adaptin C-terminal domain
    cl03906
    Location:2849
    GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins

RNA

  1. XR_002958684.1 RNA Sequence

  2. XR_002958683.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001561.2: Suppressed sequence

    Description
    NM_001001561.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.
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