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ARHGEF26 Rho guanine nucleotide exchange factor 26 [ Homo sapiens (human) ]

Gene ID: 26084, updated on 4-May-2020

Summary

Official Symbol
ARHGEF26provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 26provided by HGNC
Primary source
HGNC:HGNC:24490
See related
Ensembl:ENSG00000114790 MIM:617552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGEF; CSGEF; HMFN1864
Summary
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Expression
Broad expression in lung (RPKM 13.8), brain (RPKM 7.6) and 23 other tissues See more
Orthologs

Genomic context

See ARHGEF26 in Genome Data Viewer
Location:
3q25.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (154121003..154257827)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (153838792..153975616)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2006 Neighboring gene long intergenic non-protein coding RNA 2877 Neighboring gene ARHGEF26 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 42 Neighboring gene uncharacterized LOC105374167 Neighboring gene Sharpr-MPRA regulatory region 7914 Neighboring gene DEAH-box helicase 36 Neighboring gene G protein-coupled receptor 149 Neighboring gene DEAD-box helicase 50 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434D146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 26
Names
Rho guanine nucleotide exchange factor (GEF) 26
SH3 domain-containing guanine exchange factor
Src homology 3 domain-containing guanine nucleotide exchange factor
testicular tissue protein Li 171

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030405.1 RefSeqGene

    Range
    5388..141823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001251962.1NP_001238891.1  rho guanine nucleotide exchange factor 26 isoform 1

    See identical proteins and their annotated locations for NP_001238891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC018452, AK127282, AY552599
    Consensus CDS
    CCDS46938.1
    UniProtKB/Swiss-Prot
    Q96DR7
    UniProtKB/TrEMBL
    A0A140VJU4, B3KXG0
    Related
    ENSP00000348828.4, ENST00000356448.8
    Conserved Domains (3) summary
    cd11938
    Location:793847
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:643781
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:443622
    RhoGEF; RhoGEF domain
  2. NM_001251963.2NP_001238892.1  rho guanine nucleotide exchange factor 26 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC018452, AK123040, DB069290
    Consensus CDS
    CCDS58858.1
    UniProtKB/Swiss-Prot
    Q96DR7
    Related
    ENSP00000424446.1, ENST00000496710.5
    Conserved Domains (2) summary
    cd01221
    Location:643781
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:443622
    RhoGEF; RhoGEF domain
  3. NM_015595.4NP_056410.3  rho guanine nucleotide exchange factor 26 isoform 1

    See identical proteins and their annotated locations for NP_056410.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC018452, AY552599, DA248533, DB069290
    Consensus CDS
    CCDS46938.1
    UniProtKB/Swiss-Prot
    Q96DR7
    UniProtKB/TrEMBL
    A0A140VJU4
    Related
    ENSP00000423418.1, ENST00000465093.6
    Conserved Domains (3) summary
    cd11938
    Location:793847
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:643781
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:443622
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    154121003..154257827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512672.1XP_011510974.1  rho guanine nucleotide exchange factor 26 isoform X1

    See identical proteins and their annotated locations for XP_011510974.1

    Conserved Domains (3) summary
    cd11938
    Location:763817
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:615751
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:443615
    RhoGEF; RhoGEF domain
  2. XM_017006160.1XP_016861649.1  rho guanine nucleotide exchange factor 26 isoform X2

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187533.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    24216..164217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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